Reactome | PSMC2 [nucleoplasm]

PSMC2 [nucleoplasm]

Stable Identifier

R-HSA-174332

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S protease regulatory subunit 7, MSS1 protein

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMC2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35998 PSMC2

Gene Names

PSMC2, MSS1

Chain

initiator methionine:1, chain:2-433

Reference Genes

BioGPS Gene:5701 PSMC2

COSMIC (genes):PSMC2 PSMC2

CTD Gene:5701 PSMC2

dbSNP Gene:5701 PSMC2

ENSEMBL:ENSG00000161057.13 PSMC2

HGNC:9548 PSMC2

KEGG Gene (Homo sapiens):5701 PSMC2

Monarch:5701 PSMC2

NCBI Gene:5701 PSMC2

OMIM:154365 PSMC2

UCSC:P35998 PSMC2

Reference Transcript

Other Identifiers

0005550364

11715901_a_at

11758736_at

17049965

201067_PM_at

201067_at

201068_PM_s_at

201068_s_at

238020_PM_at

238020_at

2642700

2642708

2642709

3017189

3017207

3017208

3017209

3017214

3017216

3017217

3017224

3017226

3017228

3017230

3017231

3017233

3017234

3017235

3017236

3017237

3017238

3017239

35353_at

47823_r_at

51032_at

5701

8135250

A_23_P304287

D11094_at

GE550496

GE61412

GO:0000166

GO:0000502

GO:0000932

GO:0001649

GO:0005515

GO:0005524

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006511

GO:0008540

GO:0016020

GO:0016787

GO:0016887

GO:0022624

GO:0030154

GO:0030163

GO:0031410

GO:0032991

GO:0034774

GO:0036402

GO:0036464

GO:0043161

GO:0043226

GO:0140657

GO:1901800

GO:1904813

HMNXSV003047590

Hs.68467.0.S1_3p_at

ILMN_1768784

PH_hs_0003882

PH_hs_0040205

TC07000673.hg

g4506208_3p_a_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMC2 [secretory granule lumen]

PSMC2 [extracellular region]

PSMC2 [ficolin-1-rich granule lumen]

PSMC2 [cytosol]

Inferred To

zgc:63995 [nucleoplasm] (Danio rerio)

Rpt1 [nucleoplasm] (Drosophila melanogaster)

PSMC2 [nucleoplasm] (Bos taurus)

PSMC2 [nucleoplasm] (Caenorhabditis elegans)

PSMC2 [nucleoplasm] (Canis familiaris)

PSMC2 [nucleoplasm] (Dictyostelium discoideum)

PSMC2 [nucleoplasm] (Gallus gallus)

PSMC2 [nucleoplasm] (Mus musculus)

PSMC2 [nucleoplasm] (Rattus norvegicus)

PSMC2 [nucleoplasm] (Sus scrofa)

psmc2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001191382.1, NP_002794.1

OpenTargets

ENSG00000161057

HPA

ENSG00000161057-PSMC2

GeneCards

P35998

Ensembl

ENSP00000504608, ENST00000435765, ENSP00000502939, ENSP00000391211, ENSP00000292644, ENST00000679250, ENST00000292644, ENSP00000503663, ENSG00000161057, ENST00000678493, ENST00000679341, ENSP00000503179, ENST00000679205

PRO

P35998

Pharos - Targets

P35998

PDB

6WJN, 5VFQ, 5VHM, 5T0J, 5VHN, 5VGZ, 5L4G, 5VFP, 5VHJ, 6MSK, 5VFR, 5T0G, 5VFU, 5VHH, 5VHQ, 5T0C, 5GJQ, 6WJD, 5VHR, 5LN3, 6MSH, 5VHS, 5VFT, 5VHI, 5M32, 6MSJ, 5VFS, 5T0I, 5T0H, 6MSB, 5VHO, 5VHP, 6MSD, 6MSE, 6MSG, 5GJR, 5VHF

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.772	5
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.669	4
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.564	2
UniProt:Q96CV9 OPTN	5	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907)	0.556	3
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.527	3
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.488	2