Reactome | PSMA5 [nucleoplasm]

PSMA5 [nucleoplasm]

Stable Identifier

R-HSA-174340

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proteasome subunit alpha type 5 , Proteasome zeta chain, Macropain zeta chain, Multicatalytic endopeptidase complex zeta chain

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA5 [nucleoplasm] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA5 [nucleoplasm] (Homo sapiens)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
        
        Degradation of multiubiquitinated Cdh1 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA5 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA5 [nucleoplasm] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA5 [nucleoplasm] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Gastrulation (Homo sapiens)
  - Formation of paraxial mesoderm (Homo sapiens)
    - Somitogenesis (Homo sapiens)
      - RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA5 [nucleoplasm] (Homo sapiens)
        
        TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA5 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - Regulation of RUNX2 expression and activity (Homo sapiens)
        
        26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA5 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX3 (Homo sapiens)
      - Regulation of RUNX3 expression and activity (Homo sapiens)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA5 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Hedgehog (Homo sapiens)
  - Hedgehog 'on' state (Homo sapiens)
    - GLI2,3 are degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA5 [nucleoplasm] (Homo sapiens)
- Signaling by NOTCH (Homo sapiens)
  - Signaling by NOTCH4 (Homo sapiens)
    - Negative regulation of NOTCH4 signaling (Homo sapiens)
      - Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP outer ring [nucleoplasm] (Homo sapiens)
        
        PSMA5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P28066 PSMA5

Gene Names

PSMA5

Chain

chain:1-241

Reference Genes

BioGPS Gene:5686 PSMA5

COSMIC (genes):PSMA5 PSMA5

CTD Gene:5686 PSMA5

dbSNP Gene:5686 PSMA5

ENSEMBL:ENSG00000143106 PSMA5

HGNC:9534 PSMA5

KEGG:hsa:5686 PSMA5

Monarch:5686 PSMA5

NCBI Gene:5686 PSMA5

OMIM:176844 PSMA5

UCSC:P28066 PSMA5

Reference Transcript

Other Identifiers

11715668_a_at

16690594

201274_PM_at

201274_at

230300_PM_at

230300_at

2427066

2427067

2427068

2427069

2427070

2427071

2427072

2427073

2427075

2427076

2427077

2427078

2427079

2427080

2427088

2427090

2427091

2427092

2427093

2427094

2427095

2427096

2427097

2427098

2427102

2427103

2427104

2427105

2427106

2427107

37046_at

5686

61368_at

73310_at

7918345

A_23_P86216

GE59874

GE824853

GO:0000502

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0006511

GO:0010498

GO:0019773

GO:0030163

GO:0034774

GO:0043161

GO:0043226

GO:0051603

GO:0070062

GO:1904813

HMNXSV003024721

Hs.26037.0.A1_3p_at

ILMN_1759952

PH_hs_0002295

PH_hs_0004438

TC01002955.hg

TC01005688.hg

X61970_at

g4506186_3p_s_at

Participates

as a component of

20S CP outer ring [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMA5 [cytosol]

PSMA5 [secretory granule lumen]

PSMA5 [extracellular region]

PSMA5 [ficolin-1-rich granule lumen]

Inferred To

Psma5 [nucleoplasm] (Mus musculus)

Psma5 [nucleoplasm] (Rattus norvegicus)

psmA5 [nucleoplasm] (Dictyostelium discoideum)

Prosalpha5 [nucleoplasm] (Drosophila melanogaster)

pas-5 [nucleoplasm] (Caenorhabditis elegans)

PSMA5 [nucleoplasm] (Bos taurus)

PSMA5 [nucleoplasm] (Canis familiaris)

PSMA5 [nucleoplasm] (Gallus gallus)

PSMA5 [nucleoplasm] (Sus scrofa)

psma5 [nucleoplasm] (Danio rerio)

psma5 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_002781.2, NP_001186703.1, NP_001186701.1, NP_001186702.1

OpenTargets

ENSG00000143106

ENSEMBL

ENST00000271308, ENST00000538610, ENSP00000440618, ENSP00000271308

HPA

ENSG00000143106-PSMA5

PRO

P28066

Pharos - Targets

P28066

GlyGen

P28066

PDB

8QYJ, 7QY7, 7QXP, 7QXX, 7W3I, 7V5M, 6WJN, 8QYN, 7W3H, 7W39, 7NAN, 7W3B, 6MSB, 6MSJ, 5LF1, 6MSK, 5VFS, 6KWY, 7B12, 5VFU, 6MSG, 5VFR, 7W3C, 8QZ9, 6AVO, 5VFO, 8QYS, 7QXW, 6E5B, 8CXB, 7LXV, 5LEZ, 5LEY, 5LF3, 4R67, 7W38, 5T0H, 5T0I, 5T0C, 8CVR, 5L4G, 7PG9, 7QYA, 6MSE, 7W3M, 7W3K, 8UD9, 7QXU, 5GJQ, 7W3A, 7W3G, 7W3J, 7NAP, 7W37, 8QYL, 7NAQ, 8QYO, 5LN3, 7NAO, 8QYM, 5LF0, 6WJD, 5VFT, 6MSH, 6XMJ, 6RGQ, 5A0Q, 5VFQ, 7QXN, 7W3F, 5GJR, 5VFP, 6MSD, 7V5G, 7NHT, 6R70, 7AWE, 5LF6, 5LEX, 5LF4, 5LF7, 5M32, 4R3O, 5T0G, 5T0J, 5LE5, 8CVT, 6REY, 8CVS, 7QYB, 8BZL

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.913	16
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.744	6
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285)	0.725	9
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.725	6
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.688	3
UniProt:P25789 PSMA4	2	PSMA4 [cytosol] (R-HSA-68730) PSMA4 [nucleoplasm] (R-HSA-174324)	0.669	5
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129)	0.643	5
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	4
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.643	6
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143)	0.643	6
UniProt:P60900 PSMA6	2	PSMA6 [cytosol] (R-HSA-68734) PSMA6 [nucleoplasm] (R-HSA-174314)	0.643	6
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.643	5
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.638	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.527	5
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.527	4
UniProt:Q9UL46 PSME2	2	PSME2 [nucleoplasm] (R-HSA-174350) PSME2 [cytosol] (R-HSA-68814)	0.527	4
UniProt:Q5JS54 PSMG4	1	PSMG4 [cytosol] (R-HSA-9908036)	0.527	4
UniProt:O95456 PSMG1	1	PSMG1 [cytosol] (R-HSA-9908050)	0.527	5
UniProt:Q9BT73 PSMG3	1	PSMG3 [cytosol] (R-HSA-9908033)	0.527	4
UniProt:Q92530 PSMF1	1	PSMF1 [cytosol] (R-HSA-68818)	0.527	4
UniProt:P61289 PSME3	1	PSME3 [cytosol] (R-HSA-68816)	0.527	4
UniProt:Q969U7 PSMG2	1	PSMG2 [cytosol] (R-HSA-9908053)	0.527	4
UniProt:Q9Y244 POMP	1	POMP [cytosol] (R-HSA-9908067)	0.527	4
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	4
UniProt:P28072 PSMB6	4	PSMB6 [cytosol] (R-HSA-68756) PSMB6 [nucleoplasm] (R-HSA-174342) pro-PSMB6 [cytosol] (R-HSA-9908130) PSMB6(1-34) [cytosol] (R-HSA-9908141)	0.527	4
UniProt:Q06323 PSME1	1	PSME1 [cytosol] (R-HSA-68812)	0.527	5
UniProt:P28074 PSMB5	4	PSMB5 [cytosol] (R-HSA-68753) PSMB5 [nucleoplasm] (R-HSA-174344) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5(1-59) [cytosol] (R-HSA-9908134)	0.527	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8

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