Reactome | PSMB6 [nucleoplasm]

PSMB6 [nucleoplasm]

Stable Identifier

R-HSA-174342

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proteasome subunit beta type 6, Proteasome subunit beta type 6 precursor , Proteasome delta chain, Macropain delta chain, Multicatalytic endopeptidase complex delta chain, Proteasome subunit Y

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB6 [nucleoplasm] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB6 [nucleoplasm] (Homo sapiens)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
        
        Degradation of multiubiquitinated Cdh1 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB6 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB6 [nucleoplasm] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB6 [nucleoplasm] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Gastrulation (Homo sapiens)
  - Formation of paraxial mesoderm (Homo sapiens)
    - Somitogenesis (Homo sapiens)
      - RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB6 [nucleoplasm] (Homo sapiens)
        
        TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB6 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - Regulation of RUNX2 expression and activity (Homo sapiens)
        
        26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB6 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX3 (Homo sapiens)
      - Regulation of RUNX3 expression and activity (Homo sapiens)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB6 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Hedgehog (Homo sapiens)
  - Hedgehog 'on' state (Homo sapiens)
    - GLI2,3 are degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB6 [nucleoplasm] (Homo sapiens)
- Signaling by NOTCH (Homo sapiens)
  - Signaling by NOTCH4 (Homo sapiens)
    - Negative regulation of NOTCH4 signaling (Homo sapiens)
      - Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P28072 PSMB6

Gene Names

PSMB6, LMPY, Y

Chain

initiator methionine:, propeptide:2-34, chain:35-239

Reference Genes

BioGPS Gene:5694 PSMB6

COSMIC (genes):PSMB6 PSMB6

CTD Gene:5694 PSMB6

dbSNP Gene:5694 PSMB6

ENSEMBL:ENSG00000142507 PSMB6

HGNC:9543 PSMB6

KEGG:hsa:5694 PSMB6

Monarch:5694 PSMB6

NCBI Gene:5694 PSMB6

OMIM:600307 PSMB6

UCSC:P28072 PSMB6

Reference Transcript

RefSeq:NM_002798.2 PSMB6

Other Identifiers

11757696_a_at

16829885

208827_PM_at

208827_at

3707200

3707201

3707203

3707204

3707205

3707206

3707207

3707208

3707209

3707210

3707211

5694

8003953

941_at

A_14_P101714

A_23_P15705

D29012_at

GE560878

GO:0000502

GO:0003824

GO:0004175

GO:0004298

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005839

GO:0006508

GO:0016787

GO:0019774

GO:0030163

GO:0043161

GO:0043226

GO:0045296

GO:0051603

GO:0070062

GO:0140096

HMNXSV003023984

ILMN_1666409

PH_hs_0004444

PH_hs_0031333

TC17000052.hg

g12654058_3p_at

Participates

as a component of

20S CP inner ring [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMB6 [cytosol]

pro-PSMB6 [cytosol]

PSMB6(1-34) [cytosol]

Inferred To

Psmb6l1 [nucleoplasm] (Rattus norvegicus)

psmB6 [nucleoplasm] (Dictyostelium discoideum)

Prosbeta1 [nucleoplasm] (Drosophila melanogaster)

pbs-1 [nucleoplasm] (Caenorhabditis elegans)

Homologues of PSMB6 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of PSMB6 [nucleoplasm] (Sus scrofa)

Ghost homologue of PSMB6 [nucleoplasm] (Xenopus tropicalis)

psmb6 [nucleoplasm] (Danio rerio)

PSMB6 [nucleoplasm] (Bos taurus)

PSMB6 [nucleoplasm] (Canis familiaris)

PSMB6 [nucleoplasm] (Gallus gallus)

Psmb6 [nucleoplasm] (Mus musculus)

Psmb6 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_002789.1

Guide to Pharmacology - Targets

2407

OpenTargets

ENSG00000142507

ENSEMBL

ENST00000270586, ENSP00000270586

IntEnz

3.4.25.1

HPA

ENSG00000142507-PSMB6

PRO

P28072

Pharos - Targets

P28072

GlyGen

P28072

PDB

6R70, 5LF6, 7QYB, 8BZL, 6WJD, 5VFS, 7NAO, 8QYO, 6MSJ, 6KWY, 7W3H, 7NAQ, 5VFQ, 7W37, 7V5M, 8UD9, 5LEX, 5LF4, 5LF0, 5LF7, 7V5G, 6MSE, 7W3F, 7QY7, 7QXN, 7QXX, 7QXU, 5VFU, 6XMJ, 6WJN, 7NHT, 6MSG, 5VFO, 5GJR, 5LE5, 5T0J, 6REY, 8CVT, 8CVS, 5T0G, 5M32, 4R3O, 8CXB, 7LXV, 5LEZ, 7QYA, 7W38, 5VFT, 6MSB, 6MSK, 7W3B, 7W3J, 5VFR, 7W39, 7W3G, 7NAN, 8QYN, 4R67, 5LEY, 5LF3, 5LF1, 6MSD, 8QYS, 7W3K, 7W3M, 7W3C, 7QXP, 5GJQ, 7NAP, 6RGQ, 7W3A, 6MSH, 5A0Q, 7W3I, 5VFP, 7QXW, 5T0C, 5T0I, 8CVR, 7PG9, 5L4G, 5LN3, 5T0H

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.842	10
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129)	0.745	5
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285)	0.725	7
UniProt:Q9Y244 POMP	1	POMP [cytosol] (R-HSA-9908067)	0.667	3
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	4
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.643	4
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.643	3
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143)	0.643	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9UHB4 NDOR1	1	NDOR1 [cytosol] (R-HSA-2564776)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P28066 PSMA5	5	PSMA5 [cytosol] (R-HSA-68732) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [secretory granule lumen] (R-HSA-6803316) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328)	0.527	4
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.527	3
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	4
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.495	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	3
UniProt:P04578 env	7	ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269)	0.462	2