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PSMB1 [nucleoplasm]
Stable Identifier
R-HSA-174347
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit beta type 1 , Proteasome component C5, Macropain subunit C5, Multicatalytic endopeptidase complex subunit C5, Proteasome gamma chain
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20618 PSMB1
Gene Names
PSMB1, PSC5
Chain
propeptide:1-28, chain:29-241
Reference Genes
BioGPS Gene:5689 PSMB1
COSMIC (genes):PSMB1 PSMB1
CTD Gene:5689 PSMB1
dbSNP Gene:5689 PSMB1
ENSEMBL:ENSG00000008018 PSMB1
ENSEMBL_homo_sapiens_GENE:ENSG00000008018.9 PSMB1
HGNC:9537 PSMB1
KEGG Gene (Homo sapiens):5689 PSMB1
Monarch:5689 PSMB1
NCBI Gene:5689 PSMB1
OMIM:602017 PSMB1
UCSC:P20618 PSMB1
Reference Transcript
RefSeq:NM_002793.3 PSMB1
Other Identifiers
11715943_x_at
11754482_a_at
1447_at
17026002
200876_PM_s_at
200876_s_at
214288_PM_s_at
214288_s_at
2986503
2986504
2986506
2986510
2986511
2986514
2986515
2986521
2986522
5689
8130952
A_23_P156531
A_24_P233570
D00761_at
GE79695
GO:0000502
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0019774
GO:0030163
GO:0031410
GO:0034774
GO:0043161
GO:0043226
GO:0051603
GO:0070062
GO:1904813
HMNXSV003007545
ILMN_1789176
PH_hs_0023954
TC06002343.hg
g4506192_3p_a_at
Participates
as a component of
26S proteasome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMB1 [secretory granule lumen]
PSMB1 [extracellular region]
PSMB1 [ficolin-1-rich granule lumen]
PSMB1 [cytosol]
Inferred To
Psmb1 [nucleoplasm]
(Mus musculus)
Psmb1 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of PSMB1 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of PSMB1 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of PSMB1 [nucleoplasm]
(Drosophila melanogaster)
PSMB1 [nucleoplasm]
(Bos taurus)
PSMB1 [nucleoplasm]
(Canis familiaris)
PSMB1 [nucleoplasm]
(Gallus gallus)
PSMB1 [nucleoplasm]
(Sus scrofa)
psmb1 [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_002784.1
ZINC - World Drugs
PSB1_HUMAN
Guide to Pharmacology - Targets
2404
OpenTargets
ENSG00000008018
ZINC - FDA approved
PSB1_HUMAN
ZINC - Substances
PSB1_HUMAN
ZINC target
P20618
PRO
P20618
PDB
5L5T
,
4R3O
,
7W3I
,
5L5S
,
5T0C
,
7W39
,
5L5E
,
6MSH
,
5VFS
,
5L5I
,
5LEZ
,
7W3G
,
5LEY
,
7W3H
,
5L5H
,
7W38
,
7W37
,
5LE5
,
6WJD
,
5L5V
,
5LF1
,
7W3A
,
5GJR
,
6MSJ
,
5L5Q
,
7LXV
,
6MSK
,
5L63
,
5M32
,
5L62
,
5L61
,
7W3J
,
5T0H
,
5VFT
,
6KWY
,
5T0G
,
4R67
,
5L4G
,
5L64
,
5VFU
,
5LF3
,
5T0J
,
7W3C
,
5VFP
,
7QXX
,
7QY7
,
5T0I
,
7W3F
,
5VFO
,
7W3K
,
5L60
,
5VFR
,
7W3B
,
5L5B
,
5L5O
,
5VFQ
,
5L5X
,
5M2B
,
7W3M
,
5L5F
,
7V5M
,
6RGQ
,
7QXN
,
5LF7
,
5L5R
,
5LN3
,
7QXP
,
8CXB
,
5L5U
,
8CVS
,
7V5G
,
7NAP
,
7NAQ
,
5L5W
,
7B12
,
7NAN
,
7AWE
,
7NAO
,
5L5Y
,
7PG9
,
5L5P
,
7QYB
,
6MSG
,
8CVT
,
6REY
,
5L5D
,
5A0Q
,
7NHT
,
5L5Z
,
6WJN
,
5LF0
,
6E5B
,
6AVO
,
6MSD
,
7QYA
,
6MSE
,
5LEX
,
7QXW
,
6R70
,
5L5J
,
6MSB
,
8CVR
,
5LF6
,
5GJQ
,
6XMJ
,
7QXU
,
5LF4
ZINC - Investigational
PSB1_HUMAN
GeneCards
P20618
HPA
ENSG00000008018-PSMB1
Ensembl
ENSG00000008018
,
ENST00000262193
,
ENSP00000262193
Pharos - Targets
P20618
ZINC - Predictions - Purchasable
PSB1_HUMAN
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.795
8
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.781
7
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
7
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q9HAP6 LIN7B
2
LIN7B [plasma membrane]
(R-HSA-5216107)
LIN7B [transport vesicle membrane]
(R-HSA-9610415)
0.556
3
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.556
3
UniProt:Q9HBZ2 ARNT2
1
ARNT2 [nucleoplasm]
(R-HSA-8936838)
0.556
3
UniProt:P49821 NDUFV1
1
NDUFV1 [mitochondrial inner membrane]
(R-HSA-163926)
0.556
3
UniProt:Q96BZ8 LENG1
1
LENG1 [nucleoplasm]
(R-HSA-9769590)
0.556
3
UniProt:Q96CA5 BIRC7
1
BIRC7 [cytosol]
(R-HSA-50855)
0.556
5
UniProt:P23025 XPA
1
XPA [nucleoplasm]
(R-HSA-67437)
0.556
3
UniProt:Q9P2X3 IMPACT
1
IMPACT [cytosol]
(R-HSA-9634678)
0.556
3
UniProt:Q9H0E2 TOLLIP
4
TOLLIP [cytosol]
(R-HSA-446885)
TOLLIP [specific granule lumen]
(R-HSA-6799719)
TOLLIP [extracellular region]
(R-HSA-6800448)
TOLLIP [azurophil granule lumen]
(R-HSA-6799709)
0.556
3
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
5
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.527
3
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.495
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
8
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