Reactome | PSMB1 [nucleoplasm]

PSMB1 [nucleoplasm]

Stable Identifier

R-HSA-174347

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proteasome subunit beta type 1 , Proteasome component C5, Macropain subunit C5, Multicatalytic endopeptidase complex subunit C5, Proteasome gamma chain

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMB1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P20618 PSMB1

Gene Names

PSMB1, PSC5

Chain

propeptide:1-28, chain:29-241

Reference Genes

BioGPS Gene:5689 PSMB1

COSMIC (genes):PSMB1 PSMB1

CTD Gene:5689 PSMB1

dbSNP Gene:5689 PSMB1

ENSEMBL:ENSG00000008018 PSMB1

HGNC:9537 PSMB1

KEGG Gene (Homo sapiens):5689 PSMB1

Monarch:5689 PSMB1

NCBI Gene:5689 PSMB1

OMIM:602017 PSMB1

UCSC:P20618 PSMB1

Reference Transcript

RefSeq:NM_002793.3 PSMB1

Other Identifiers

0003870136

11715943_x_at

11754482_a_at

1447_at

17026002

200876_s_at

214288_s_at

2986503

2986504

2986506

2986510

2986511

2986514

2986515

2986521

2986522

5689

8130952

A_23_P156531

A_24_P233570

D00761_at

GE79695

GO:0000165

GO:0000209

GO:0000278

GO:0000502

GO:0002223

GO:0002376

GO:0002479

GO:0003674

GO:0004175

GO:0004298

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0006464

GO:0006520

GO:0006521

GO:0006810

GO:0006950

GO:0007049

GO:0007165

GO:0007267

GO:0008150

GO:0008233

GO:0009056

GO:0009058

GO:0010499

GO:0010972

GO:0016032

GO:0016192

GO:0016579

GO:0019774

GO:0022607

GO:0030154

GO:0031145

GO:0031146

GO:0031410

GO:0032991

GO:0033209

GO:0034641

GO:0034655

GO:0034774

GO:0036388

GO:0038061

GO:0038095

GO:0043161

GO:0043226

GO:0043312

GO:0043488

GO:0043687

GO:0044281

GO:0044403

GO:0048856

GO:0050852

GO:0051603

GO:0055085

GO:0060071

GO:0061418

GO:0065003

GO:0070062

GO:0070498

GO:0090090

GO:0090263

GO:1901990

GO:1902036

GO:1904813

HMNXSV003007545

ILMN_1789176

PH_hs_0023954

TC06002343.hg

g4506192_3p_a_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMB1 [secretory granule lumen]

PSMB1 [extracellular region]

PSMB1 [ficolin-1-rich granule lumen]

PSMB1 [cytosol]

Inferred To

Prosbeta6 [nucleoplasm] (Drosophila melanogaster)

pam1 [nucleoplasm] (Schizosaccharomyces pombe)

pbs-6 [nucleoplasm] (Caenorhabditis elegans)

Psmb1 [nucleoplasm] (Mus musculus)

Psmb1 [nucleoplasm] (Rattus norvegicus)

psmB1 [nucleoplasm] (Dictyostelium discoideum)

PSMB1 [nucleoplasm] (Canis familiaris)

PSMB1 [nucleoplasm] (Sus scrofa)

psmb1 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_002784.1

ZINC - World Drugs

PSB1_HUMAN

Guide to Pharmacology - Targets

2404

OpenTargets

ENSG00000008018

ZINC - FDA approved

PSB1_HUMAN

ZINC - Substances

PSB1_HUMAN

ZINC target

P20618

PRO

P20618

GlyGen

P20618

PDB

6MSB, 6WJD, 5L5Y, 5L64, 6MSE, 5L5W, 5L62, 5LEZ, 4R67, 5L5V, 6MSH, 5L60, 5LEX, 5L5U, 6MSK, 5L5T, 5LF1, 5L5S, 5L5R, 6R70, 5A0Q, 5L5Q, 6AVO, 5L5P, 5VFP, 5L5O, 7AWE, 5VFR, 5M32, 5T0G, 7V5M, 5LN3, 5VFT, 5L5J, 6XMJ, 5T0I, 5LF3, 5L5I, 6RGQ, 7NHT, 5L5H, 5LF6, 5L5F, 6REY, 5L5E, 7PG9, 5L5D, 5L5B, 5L5Z, 6MSD, 5L5X, 5L63, 6MSG, 5L61, 6WJN, 5LEY, 6MSJ, 4R3O, 6KWY, 5M2B, 5LF0, 6E5B, 5L4G, 5VFO, 7V5G, 7LXV, 5T0C, 5VFQ, 5VFS, 5T0H, 5VFU, 5GJR, 5T0J, 5LF4, 5GJQ, 5LF7, 5LE5

ZINC - Investigational

PSB1_HUMAN

GeneCards

P20618

HPA

ENSG00000008018-PSMB1

Ensembl

ENSG00000008018, ENSP00000262193, ENST00000262193

Pharos - Targets

P20618

ZINC - Predictions - Purchasable

PSB1_HUMAN

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.795	8
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.781	7
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	7
UniProt:Q9P2X3 IMPACT	1	IMPACT [cytosol] (R-HSA-9634678)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	5
UniProt:Q9H0E2 TOLLIP	4	TOLLIP [cytosol] (R-HSA-446885) TOLLIP [azurophil granule lumen] (R-HSA-6799709) TOLLIP [extracellular region] (R-HSA-6800448) TOLLIP [specific granule lumen] (R-HSA-6799719)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9HAP6 LIN7B	2	LIN7B [transport vesicle membrane] (R-HSA-9610415) LIN7B [plasma membrane] (R-HSA-5216107)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) SMAD3 [cytosol] (R-HSA-170855) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184)	0.556	3
UniProt:P49821 NDUFV1	1	NDUFV1 [mitochondrial inner membrane] (R-HSA-163926)	0.556	3
UniProt:P23025 XPA	1	XPA [nucleoplasm] (R-HSA-67437)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.527	3