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PSMB1 [nucleoplasm]
Stable Identifier
R-HSA-174347
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit beta type 1 , Proteasome component C5, Macropain subunit C5, Multicatalytic endopeptidase complex subunit C5, Proteasome gamma chain
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20618 PSMB1
Gene Names
PSMB1, PSC5
Chain
propeptide:1-28, chain:29-241
Reference Genes
BioGPS Gene:5689 PSMB1
COSMIC (genes):PSMB1 PSMB1
CTD Gene:5689 PSMB1
dbSNP Gene:5689 PSMB1
ENSEMBL:ENSG00000008018 PSMB1
HGNC:9537 PSMB1
KEGG Gene (Homo sapiens):5689 PSMB1
Monarch:5689 PSMB1
NCBI Gene:5689 PSMB1
OMIM:602017 PSMB1
UCSC:P20618 PSMB1
Reference Transcript
RefSeq:NM_002793.3 PSMB1
Other Identifiers
0003870136
11715943_x_at
11754482_a_at
1447_at
17026002
200876_s_at
214288_s_at
2986503
2986504
2986506
2986510
2986511
2986514
2986515
2986521
2986522
5689
8130952
A_23_P156531
A_24_P233570
D00761_at
GE79695
GO:0000165
GO:0000209
GO:0000278
GO:0000502
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0004175
GO:0004298
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0006464
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0008233
GO:0009056
GO:0009058
GO:0010499
GO:0010972
GO:0016032
GO:0016192
GO:0016579
GO:0019774
GO:0022607
GO:0030154
GO:0031145
GO:0031146
GO:0031410
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0034774
GO:0036388
GO:0038061
GO:0038095
GO:0043161
GO:0043226
GO:0043312
GO:0043488
GO:0043687
GO:0044281
GO:0044403
GO:0048856
GO:0050852
GO:0051603
GO:0055085
GO:0060071
GO:0061418
GO:0065003
GO:0070062
GO:0070498
GO:0090090
GO:0090263
GO:1901990
GO:1902036
GO:1904813
HMNXSV003007545
ILMN_1789176
PH_hs_0023954
TC06002343.hg
g4506192_3p_a_at
Participates
as a component of
26S proteasome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMB1 [secretory granule lumen]
PSMB1 [extracellular region]
PSMB1 [ficolin-1-rich granule lumen]
PSMB1 [cytosol]
Inferred To
Prosbeta6 [nucleoplasm]
(Drosophila melanogaster)
pam1 [nucleoplasm]
(Schizosaccharomyces pombe)
pbs-6 [nucleoplasm]
(Caenorhabditis elegans)
Psmb1 [nucleoplasm]
(Mus musculus)
Psmb1 [nucleoplasm]
(Rattus norvegicus)
psmB1 [nucleoplasm]
(Dictyostelium discoideum)
PSMB1 [nucleoplasm]
(Canis familiaris)
PSMB1 [nucleoplasm]
(Sus scrofa)
psmb1 [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_002784.1
ZINC - World Drugs
PSB1_HUMAN
Guide to Pharmacology - Targets
2404
OpenTargets
ENSG00000008018
ZINC - FDA approved
PSB1_HUMAN
ZINC - Substances
PSB1_HUMAN
ZINC target
P20618
PRO
P20618
GlyGen
P20618
PDB
6MSB
,
6WJD
,
5L5Y
,
5L64
,
6MSE
,
5L5W
,
5L62
,
5LEZ
,
4R67
,
5L5V
,
6MSH
,
5L60
,
5LEX
,
5L5U
,
6MSK
,
5L5T
,
5LF1
,
5L5S
,
5L5R
,
6R70
,
5A0Q
,
5L5Q
,
6AVO
,
5L5P
,
5VFP
,
5L5O
,
7AWE
,
5VFR
,
5M32
,
5T0G
,
7V5M
,
5LN3
,
5VFT
,
5L5J
,
6XMJ
,
5T0I
,
5LF3
,
5L5I
,
6RGQ
,
7NHT
,
5L5H
,
5LF6
,
5L5F
,
6REY
,
5L5E
,
7PG9
,
5L5D
,
5L5B
,
5L5Z
,
6MSD
,
5L5X
,
5L63
,
6MSG
,
5L61
,
6WJN
,
5LEY
,
6MSJ
,
4R3O
,
6KWY
,
5M2B
,
5LF0
,
6E5B
,
5L4G
,
5VFO
,
7V5G
,
7LXV
,
5T0C
,
5VFQ
,
5VFS
,
5T0H
,
5VFU
,
5GJR
,
5T0J
,
5LF4
,
5GJQ
,
5LF7
,
5LE5
ZINC - Investigational
PSB1_HUMAN
GeneCards
P20618
HPA
ENSG00000008018-PSMB1
Ensembl
ENSG00000008018
,
ENSP00000262193
,
ENST00000262193
Pharos - Targets
P20618
ZINC - Predictions - Purchasable
PSB1_HUMAN
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.795
8
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.781
7
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
7
UniProt:Q9P2X3 IMPACT
1
IMPACT [cytosol]
(R-HSA-9634678)
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
5
UniProt:Q9H0E2 TOLLIP
4
TOLLIP [cytosol]
(R-HSA-446885)
TOLLIP [azurophil granule lumen]
(R-HSA-6799709)
TOLLIP [extracellular region]
(R-HSA-6800448)
TOLLIP [specific granule lumen]
(R-HSA-6799719)
0.556
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q9HAP6 LIN7B
2
LIN7B [transport vesicle membrane]
(R-HSA-9610415)
LIN7B [plasma membrane]
(R-HSA-5216107)
0.556
3
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
3
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
SMAD3 [cytosol]
(R-HSA-170855)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
0.556
3
UniProt:P49821 NDUFV1
1
NDUFV1 [mitochondrial inner membrane]
(R-HSA-163926)
0.556
3
UniProt:P23025 XPA
1
XPA [nucleoplasm]
(R-HSA-67437)
0.556
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.527
3
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