Reactome | PSME2 [nucleoplasm]

PSME2 [nucleoplasm]

Stable Identifier

R-HSA-174350

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proteasome activator complex subunit 2, Proteasome activator 28-beta subunit, PA28beta, PA28b, Activator of multicatalytic protease subunit 2, 11S regulator complex beta subunit, REG-beta

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSME2 [nucleoplasm] (Homo sapiens)

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
        
        Expression of Proteasome activator complex subunit 2 (Homo sapiens)
        
        PSME2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UL46 PSME2

Gene Names

PSME2

Chain

initiator methionine:1, chain:2-239

Reference Genes

BioGPS Gene:5721 PSME2

COSMIC (genes):PSME2 PSME2

CTD Gene:5721 PSME2

dbSNP Gene:5721 PSME2

ENSEMBL:ENSG00000100911 PSME2

ENSEMBL:ENSG00000100911.16 PSME2

ENSEMBL:ENSG00000284889.2 PSME2

HGNC:9569 PSME2

KEGG Gene (Homo sapiens):5721 PSME2

Monarch:5721 PSME2

NCBI Gene:5721 PSME2

OMIM:602161 PSME2

UCSC:Q9UL46 PSME2

Reference Transcript

RefSeq:NM_002818.2 PSME2

Other Identifiers

1184_at

16791059

201762_PM_s_at

201762_s_at

2749686

2749687

2821648

3238435

3489180

3489181

3489182

3557812

3557813

3557815

3557817

3557819

3557820

3557823

3557825

3557827

3557829

3557832

3557834

41171_at

5721

7978123

A_23_P65427

D45248_at

GE81197

GO:0000278

GO:0000502

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0008537

GO:0010950

GO:0016020

GO:0030163

GO:0042802

GO:0043226

GO:0061133

GO:0061136

GO:0070062

GO:0098772

GO:2000045

HMNXSV003006858

HMNXSV003016126

TC14000968.hg

g4506236_3p_a_at

Participates

as an output of

Expression of Proteasome activator complex subunit 2 (Homo sapiens)

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSME2 [cytosol]

Inferred To

Ghost homologue of PSME2 [nucleoplasm] (Gallus gallus)

psmE3 [nucleoplasm] (Dictyostelium discoideum)

PSME2 [nucleoplasm] (Bos taurus)

PSME2 [nucleoplasm] (Canis familiaris)

PSME2 [nucleoplasm] (Sus scrofa)

psme2 [nucleoplasm] (Xenopus tropicalis)

unp309 [nucleoplasm] (Danio rerio)

Psme2 [nucleoplasm] (Mus musculus)

Psme2 [nucleoplasm] (Rattus norvegicus)

REG [nucleoplasm] (Drosophila melanogaster)

psme-3 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002809.2

OpenTargets

ENSG00000100911

GeneCards

Q9UL46

HPA

ENSG00000100911-PSME2

Ensembl

ENST00000645325, ENSG00000284889, ENSG00000100911, ENST00000216802, ENSP00000216802, ENSP00000495790

PRO

Q9UL46

Pharos - Targets

Q9UL46

PDB

7DRW, 7NAP, 7DR6, 8CXB, 7NAO

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UL46 PSME2	2	PSME2 [nucleoplasm] (R-HSA-174350) PSME2 [cytosol] (R-HSA-68814)	0.718	6
UniProt:Q06323 PSME1	2	PSME1 [nucleoplasm] (R-HSA-174320) PSME1 [cytosol] (R-HSA-68812)	0.666	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	11
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q9BVJ7 DUS23			0.556	3
UniProt:Q9BZL1 UBL5	1	UBL5 [nucleoplasm] (R-HSA-9770255)	0.556	3
UniProt:P28065 PSMB9	2	PSMB9 [nucleoplasm] (R-HSA-174334) PSMB9 [cytosol] (R-HSA-68765)	0.527	2