Reactome | PSMA7 [nucleoplasm]

PSMA7 [nucleoplasm]

Stable Identifier

R-HSA-174351

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proteasome subunit alpha type 7 , Proteasome subunit RC6-1, Proteasome subunit XAPC7

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMA7 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14818 PSMA7

Gene Names

PSMA7, HSPC

Chain

chain:1-248

Reference Genes

BioGPS Gene:5688 PSMA7

COSMIC (genes):PSMA7 PSMA7

CTD Gene:5688 PSMA7

dbSNP Gene:5688 PSMA7

ENSEMBL:ENSG00000101182 PSMA7

ENSEMBL_homo_sapiens_GENE:ENSG00000101182.15 PSMA7

HGNC:9536 PSMA7

KEGG Gene (Homo sapiens):5688 PSMA7

Monarch:5688 PSMA7

NCBI Gene:5688 PSMA7

OMIM:606607 PSMA7

UCSC:O14818 PSMA7

Reference Transcript

RefSeq:NM_002792.3 PSMA7

Other Identifiers

11734682_a_at

16920910

201114_PM_x_at

201114_x_at

216088_PM_s_at

216088_s_at

33449_at

3912862

3912863

3912864

3912865

3912867

3912870

3912872

3912873

3912874

3912875

3912876

3912877

3912879

3912883

3912885

3912886

5688

8067382

A_23_P91468

GE561832

GE62892

GO:0000502

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0006511

GO:0010498

GO:0019773

GO:0030163

GO:0042802

GO:0043161

GO:0043226

GO:0051603

GO:0070062

GO:0098794

HMNXSV003028165

Hs.233952.3.S1_3p_a_at

ILMN_1701962

PH_hs_0012783

PH_hs_0035712

TC20001005.hg

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMA7 [cytosol]

Inferred To

Ghost homologue of PSMA7 [nucleoplasm] (Danio rerio)

Prosalpha4 [nucleoplasm] (Drosophila melanogaster)

PSMA7 [nucleoplasm] (Bos taurus)

PSMA7 [nucleoplasm] (Canis familiaris)

PSMA7 [nucleoplasm] (Gallus gallus)

PSMA7 [nucleoplasm] (Sus scrofa)

pas-4 [nucleoplasm] (Caenorhabditis elegans)

Psma7 [nucleoplasm] (Mus musculus)

Psma7 [nucleoplasm] (Rattus norvegicus)

psmA7 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002783.1

OpenTargets

ENSG00000101182

GeneCards

O14818

HPA

ENSG00000101182-PSMA7

Ensembl

ENST00000370873, ENST00000370858, ENST00000370861, ENSP00000359898, ENSP00000359910, ENSP00000359895, ENSG00000101182

PRO

O14818

Pharos - Targets

O14818

PDB

8CVS, 6MSB, 7W3K, 7B12, 7W37, 5T0C, 8CXB, 5M32, 7QYB, 6KWY, 5VFT, 6MSD, 6AVO, 4R67, 6RGQ, 6MSG, 8QYL, 5LEX, 7W3G, 7NHT, 7W3B, 7NAN, 5A0Q, 5T0G, 7AWE, 6REY, 5GJR, 6MSH, 7QXU, 6MSJ, 5T0H, 5LEY, 5LF0, 7NAO, 8BZL, 8UD9, 6MSK, 5T0I, 7W3J, 5LF3, 8CVR, 5T0J, 7QY7, 7V5M, 8QYO, 6WJD, 7NAQ, 6R70, 7QXW, 8QZ9, 7QYA, 5VFR, 8CVT, 5LF6, 5LN3, 7W38, 5LE5, 5VFS, 6WJN, 5L4G, 7W3F, 6E5B, 8QYJ, 5LF7, 6MSE, 7W3M, 7W39, 7QXN, 5VFU, 7W3H, 7W3A, 7QXP, 7LXV, 4R3O, 8QYM, 5LEZ, 5GJQ, 6XMJ, 5VFO, 5LF1, 7W3C, 8QYS, 7W3I, 7NAP, 5VFP, 7PG9, 7QXX, 8QYN, 5VFQ, 7V5G, 5LF4

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	13
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.638	3
UniProt:Q5VVQ6 YOD1	1	YOD1 [cytosol] (R-HSA-6781909)	0.556	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q16665 HIF1A	7	HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.544	2
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.527	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	8

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