GCL ligates L-Glu to L-Cys

Stable Identifier
R-HSA-174367
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Glutamate and cysteine combine
ReviewStatus
5/5
Locations in the PathwayBrowser
General
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The first step in the formation of glutathione is the ligation of glutamate with cysteine, catalysed by the dimeric protein glutamate-cysteine ligase, GCL (Gipp et al. 1995, Misra & Griffith 1998).
Literature References
Participants
Participates
Catalyst Activity

glutamate-cysteine ligase activity of GCL [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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