Processive synthesis on the C-strand of the telomere

Stable Identifier
R-HSA-174414
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
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Processive synthesis on the C-strand of the telomere
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Once polymerase switching from pol alpha to pol delta is complete the processive synthesis of a short run of DNA called an Okazaki fragment begins. DNA synthesis is discontinuous and as the extending Okazaki fragment reaches the RNA primer, this primer is folded into a single-stranded flap, which is removed by endonucleases. The process of extension is completed by the ligation of adjacent Okazaki fragments.

Literature References
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Events
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as an event of
Event Information
Go Biological Process
telomere maintenance via semi-conservative replication (0032201)
Orthologous Events
Processive synthesis on the C-strand of the telomere (Canis familiaris)
Processive synthesis on the C-strand of the telomere (Danio rerio)
Processive synthesis on the C-strand of the telomere (Mus musculus)
Processive synthesis on the C-strand of the telomere (Rattus norvegicus)
Processive synthesis on the C-strand of the telomere (Schizosaccharomyces pombe)
Processive synthesis on the C-strand of the telomere (Sus scrofa)
Authored
Blackburn, EH  (2006-03-10)
Seidel, J  (2006-03-10)
Reviewed
Price, C  (2006-07-13)
Hayashi, MT  (2020-04-29)
Created
Gillespie, ME  (2006-02-17)
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