Processive synthesis on the C-strand of the telomere

Stable Identifier
R-HSA-174414
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Processive synthesis on the C-strand of the telomere
Click the image above or here to open this pathway in the Pathway Browser

Once polymerase switching from pol alpha to pol delta is complete the processive synthesis of a short run of DNA called an Okazaki fragment begins. DNA synthesis is discontinuous and as the extending Okazaki fragment reaches the RNA primer, this primer is folded into a single-stranded flap, which is removed by endonucleases. The process of extension is completed by the ligation of adjacent Okazaki fragments.

Literature References
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
telomere maintenance via semi-conservative replication (0032201)
Orthologous Events
Processive synthesis on the C-strand of the telomere (Canis familiaris)
Processive synthesis on the C-strand of the telomere (Danio rerio)
Processive synthesis on the C-strand of the telomere (Mus musculus)
Processive synthesis on the C-strand of the telomere (Rattus norvegicus)
Processive synthesis on the C-strand of the telomere (Schizosaccharomyces pombe)
Processive synthesis on the C-strand of the telomere (Sus scrofa)
Authored
Blackburn, EH  (2006-03-09)
Seidel, J  (2006-03-09)
Reviewed
Hayashi, MT  (2020-04-28)
Price, C  (2006-07-13)
Created
Gillespie, ME  (2006-02-17)
Cite Us!