Reactome | nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]

nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]

Stable Identifier

R-HSA-174587

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Exocytosis of nascent chylomicrons

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

While the export pathway for nascent chylomicrons has not been directly characterized in human cells, the requirement for SAR1B protein for normal chylomicron export in vivo (Jones et al. 2003) indicates that nascent chylomicrons are exported from the endoplasmic reticulum via the Golgi apparatus in COPII vesicles.

Literature References

PubMed ID	Title	Journal	Year
12692552	Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders Shoulders, CC, Roy, CC, Eichenbaum-Voline, S, Meadows, N, Mensenkamp, AR, Jones, EL, Patel, HN, Scott, J, Infante, R, Quattrone, A, Bonney, SA, Angelin, B, Rudling, M, Freemont, PS, Levy, E, Islam, SA, Naik, S, Myrdal, U, Jones, B, Naoumova, RP, Annesi, G	Nat Genet	2003