Reactome | APOA1(25-267) [endoplasmic reticulum lumen]

APOA1(25-267) [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-174640

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

apoA-I, apolipoprotein A-I

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P02647 APOA1

Gene Names

APOA1

Chain

signal peptide:1-18, chain:19-267, chain:25-267, chain:25-266

Reference Genes

BioGPS Gene:335 APOA1

COSMIC (genes):APOA1 APOA1

CTD Gene:335 APOA1

dbSNP Gene:335 APOA1

ENSEMBL:ENSG00000118137 APOA1

ENSEMBL_homo_sapiens_GENE:ENSG00000118137.10 APOA1

HGNC:600 APOA1

KEGG Gene (Homo sapiens):335 APOA1

Monarch:335 APOA1

NCBI Gene:335 APOA1

OMIM:107680 APOA1

UCSC:P02647 APOA1

Reference Transcript

Other Identifiers

11757663_x_at

11757705_x_at

11757734_x_at

11758012_x_at

11758197_s_at

11758353_s_at

16744723

204450_PM_x_at

204450_x_at

217073_PM_x_at

217073_x_at

335

3392987

3392988

3392989

3392990

3392991

3392992

3392993

3392994

3392995

39106_at

7951865

8077185

A_23_P203191

A_33_P3298539

GE62851

GO:0001540

GO:0001932

GO:0001935

GO:0002376

GO:0002719

GO:0005102

GO:0005215

GO:0005319

GO:0005515

GO:0005543

GO:0005576

GO:0005615

GO:0005768

GO:0005769

GO:0005783

GO:0005788

GO:0005829

GO:0005886

GO:0006629

GO:0006644

GO:0006656

GO:0006695

GO:0006869

GO:0006954

GO:0007010

GO:0007155

GO:0007186

GO:0007229

GO:0008035

GO:0008202

GO:0008203

GO:0008211

GO:0008289

GO:0010804

GO:0010875

GO:0010903

GO:0015485

GO:0016192

GO:0018158

GO:0018206

GO:0019899

GO:0019915

GO:0022600

GO:0023052

GO:0030139

GO:0030300

GO:0030301

GO:0030312

GO:0030325

GO:0031012

GO:0031072

GO:0031410

GO:0032489

GO:0032691

GO:0033344

GO:0033700

GO:0034115

GO:0034190

GO:0034191

GO:0034361

GO:0034364

GO:0034366

GO:0034375

GO:0034380

GO:0034384

GO:0034774

GO:0035025

GO:0036211

GO:0042157

GO:0042158

GO:0042632

GO:0042802

GO:0042803

GO:0043226

GO:0043534

GO:0043691

GO:0045499

GO:0046470

GO:0048018

GO:0048856

GO:0048870

GO:0050728

GO:0050766

GO:0050821

GO:0050919

GO:0051180

GO:0051345

GO:0051496

GO:0055091

GO:0060228

GO:0060354

GO:0060761

GO:0061024

GO:0062023

GO:0065003

GO:0070062

GO:0070328

GO:0070508

GO:0070653

GO:0071682

GO:0071813

GO:0072562

GO:0090205

GO:0098772

GO:0120009

GO:0120020

GO:1900026

GO:1902995

GO:1903561

GO:1905920

HMNXSV003026166

ILMN_1690884

PH_hs_0035488

PH_hs_0036613

TC11002328.hg

X01038_rna1_s_at

g4557320_3p_a_at

Participates

as an input of

ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Homo sapiens)

as a component of

nascent chylomicron [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

APOA1(25-266) [secretory granule lumen]

APOA1(25-267) [cytosol]

APOA1(25-267) [early endosome]

APOA1(19-266) [extracellular region]

APOA1(25-266) [plasma membrane]

Variant apolipoprotein AI [extracellular region]

APOA1(25-266) [endocytic vesicle lumen]

p-APOA1 [endoplasmic reticulum lumen]

APOA1 [endoplasmic reticulum lumen]

APOA1(25-266) [extracellular region]

Inferred To

APOA1 [endoplasmic reticulum lumen] (Bos taurus)

APOA1 [endoplasmic reticulum lumen] (Canis familiaris)

APOA1 [endoplasmic reticulum lumen] (Gallus gallus)

APOA1 [endoplasmic reticulum lumen] (Sus scrofa)

Apoa1 [endoplasmic reticulum lumen] (Mus musculus)

Apoa1 [endoplasmic reticulum lumen] (Rattus norvegicus)

Cross References

RefSeq

NP_001304947.1, NP_000030.1, NP_001304950.1, NP_001304946.1

OpenTargets

ENSG00000118137

HPA

ENSG00000118137-APOA1

GeneCards

P02647

Ensembl

ENSG00000118137, ENSP00000364472, ENSP00000236850, ENST00000236850, ENST00000375320, ENSP00000352471, ENSP00000364469, ENST00000359492, ENST00000375323

PRO

P02647

Pharos - Targets

P02647

Orphanet

15936

HMDB Protein

HMDBP01620

PDB

1AV1, 6CM1, 6W4F, 6W4E, 6CLZ, 2N5E, 4V6M, 2MSC, 6CCH, 2MSD, 1ODP, 8EQS, 7KJR, 3K2S, 2MSE, 1ODQ, 6PTS, 6PTW, 1ODR, 3R2P, 7RSC, 6CCX, 1GW3, 1GW4, 6CC9, 7RSE

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02647 APOA1	11	APOA1(25-266) [secretory granule lumen] (R-HSA-350761) APOA1(25-267) [cytosol] (R-HSA-2395781) APOA1(25-267) [early endosome] (R-HSA-2429641) APOA1(25-267) [endoplasmic reticulum lumen] (R-HSA-174640) APOA1(19-266) [extracellular region] (R-HSA-264771) APOA1(25-266) [plasma membrane] (R-HSA-216742) Variant apolipoprotein AI [extracellular region] (R-HSA-976865) APOA1(25-266) [endocytic vesicle lumen] (R-HSA-2239460) p-APOA1 [endoplasmic reticulum lumen] (R-HSA-8957081) APOA1 [endoplasmic reticulum lumen] (R-HSA-8956724) APOA1(25-266) [extracellular region] (R-HSA-174720)	0.972	28
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.747	8
UniProt:Q96DZ9-2 CMTM5			0.718	6
UniProt:Q16659 MAPK6 gene	6	ub-MAPK6 [cytosol] (R-HSA-5687000) MAPK6 [cytosol] (R-HSA-5686979) p-S189 MAPK6 [cytosol] (R-HSA-5687019) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) MAPK6 [nucleoplasm] (R-HSA-5692686) p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665)	0.659	3
UniProt:P04180 LCAT	1	LCAT [extracellular region] (R-HSA-194239)	0.623	2
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.623	3
UniProt:O95477 ABCA1	11	ABCA1 W590S [plasma membrane] (R-HSA-5682201) ABCA1 N935S [plasma membrane] (R-HSA-5682200) ABCA1 C1417R [plasma membrane] (R-HSA-5682190) ABCA1 S1446L [plasma membrane] (R-HSA-5682195) ABCA1 R587W [plasma membrane] (R-HSA-5682197) ABCA1 [plasma membrane] (R-HSA-194209) 4xPALM-C-p-2S-ABCA1 [plasma membrane] (R-HSA-5682069) 4xPALM-C-ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682085) 4xPALM-C-ABCA1 [plasma membrane] (R-HSA-5682091) ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682105) ABCA1 Q537R [plasma membrane] (R-HSA-5682199)	0.621	8
UniProt:P00738 HP	7	HP [specific granule lumen] (R-HSA-6799622) HP [extracellular region] (R-HSA-6799677) HP [tertiary granule lumen] (R-HSA-6800879) 5xHC-HP(162-406) [endocytic vesicle lumen] (R-HSA-2230973) 7xHC-HP(19-160) [endocytic vesicle lumen] (R-HSA-2230994) 5xHC-HP(162-406) [extracellular region] (R-HSA-2168875) 7xHC-HP(19-160) [extracellular region] (R-HSA-2168848)	0.558	3
UniProt:Q9Y371 SHLB1			0.556	3
UniProt:Q96DZ9 CKLF5			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.527	7
UniProt:Q8NHS2 AATC2			0.527	2
UniProt:P05091 ALDH2	1	ALDH2 [mitochondrial matrix] (R-HSA-71718)	0.527	2
UniProt:Q9H8H2 DDX31			0.527	2
UniProt:Q96NG5 ZNF558	1	ZNF558 [nucleoplasm] (R-HSA-1973893)	0.527	2
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.499	2
UniProt:P23142 FBLN1	1	FBLN1 [extracellular region] (R-HSA-2161389)	0.488	2
UniProt:P02671 FGA	8	FGA(20-866) [platelet alpha granule lumen] (R-HSA-140920) FGA(20-866) [extracellular region] (R-HSA-140841) Variant fibrinogen alpha chain [extracellular region] (R-HSA-976905) p-FGA [endoplasmic reticulum lumen] (R-HSA-8957043) FGA [endoplasmic reticulum lumen] (R-HSA-8956714) FGA [plasma membrane] (R-HSA-140916) FGA(20-35) [extracellular region] (R-HSA-140867) FGA [extracellular region] (R-HSA-140583)	0.483	2

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