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MTTP [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-174688
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
MTP, microsomal triglyceride transfer protein
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein assembly (Homo sapiens)
Chylomicron assembly (Homo sapiens)
ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Homo sapiens)
MTTP [endoplasmic reticulum lumen] (Homo sapiens)
MTTP:PDI:lipid complex [endoplasmic reticulum lumen] (Homo sapiens)
MTTP [endoplasmic reticulum lumen] (Homo sapiens)
ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Homo sapiens)
MTTP:PDI:lipid complex [endoplasmic reticulum lumen] (Homo sapiens)
MTTP [endoplasmic reticulum lumen] (Homo sapiens)
VLDL assembly (Homo sapiens)
MTTP lipidates APOB-100, forming a pre-VLDL (Homo sapiens)
MTTP [endoplasmic reticulum lumen] (Homo sapiens)
MTTP:PDI:lipid complex [endoplasmic reticulum lumen] (Homo sapiens)
MTTP [endoplasmic reticulum lumen] (Homo sapiens)
MTTP:lomitapide [endoplasmic reticulum lumen] (Homo sapiens)
MTTP:PDI:lipid complex [endoplasmic reticulum lumen] (Homo sapiens)
MTTP [endoplasmic reticulum lumen] (Homo sapiens)
Plasma lipoprotein remodeling (Homo sapiens)
LDL remodeling (Homo sapiens)
MTTP binds lomitapide (Homo sapiens)
MTTP:PDI:lipid complex [endoplasmic reticulum lumen] (Homo sapiens)
MTTP [endoplasmic reticulum lumen] (Homo sapiens)
MTTP:lomitapide [endoplasmic reticulum lumen] (Homo sapiens)
MTTP:PDI:lipid complex [endoplasmic reticulum lumen] (Homo sapiens)
MTTP [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P55157 MTTP
Gene Names
MTTP, MTP
Chain
signal peptide:1-18, chain:19-894
Reference Genes
BioGPS Gene:4547 MTTP
COSMIC (genes):MTTP MTTP
CTD Gene:4547 MTTP
dbSNP Gene:4547 MTTP
ENSEMBL:ENSG00000138823 MTTP
HGNC:7467 MTTP
KEGG:hsa:4547 MTTP
Monarch:4547 MTTP
NCBI Gene:4547 MTTP
OMIM:157147 MTTP
UCSC:P55157 MTTP
Reference Transcript
RefSeq:NM_001300785.1 MTTP
RefSeq:NM_000253.3 MTTP
Other Identifiers
11729799_at
11729800_a_at
11749111_a_at
11761391_at
16969197
205675_PM_at
205675_at
2737244
2737245
2737246
2737248
2737250
2737258
2737259
2737262
2737263
2737265
2737266
2737267
2737268
2737269
2737270
2737271
2737272
2737273
2737274
2737275
2737276
2737277
2737279
2737282
2737284
2737286
2737287
2737288
2737289
38891_at
4547
8096580
84656_at
A_14_P131251
A_14_P200128
A_23_P213171
A_33_P3215457
GE62503
GE726749
GO:0005215
GO:0005319
GO:0005515
GO:0005548
GO:0005783
GO:0005788
GO:0005794
GO:0005829
GO:0006629
GO:0006641
GO:0006869
GO:0007623
GO:0008289
GO:0009306
GO:0015914
GO:0015918
GO:0016323
GO:0031526
GO:0031528
GO:0031982
GO:0034185
GO:0034197
GO:0034374
GO:0034377
GO:0034378
GO:0034379
GO:0042157
GO:0042632
GO:0042953
GO:0043226
GO:0043235
GO:0044877
GO:0046982
GO:0051592
GO:0051649
GO:0061024
GO:0065003
GO:0120009
GO:0120013
GO:0120014
GO:0120019
GO:0120020
GO:0140344
GO:1902388
GO:1902389
GO:1904121
HMNXSV003006589
HMNXSV003050010
Hs.195799.0.S2_3p_at
ILMN_1774742
PH_hs_0011571
TC04000516.hg
X91148_at
Participates
as a component of
MTTP:PDI:lipid complex [endoplasmic reticulum lumen] (Homo sapiens)
Inferred To
mttp [endoplasmic reticulum lumen]
(Danio rerio)
mttp [endoplasmic reticulum lumen]
(Xenopus tropicalis)
MTTP [endoplasmic reticulum lumen]
(Bos taurus)
MTTP [endoplasmic reticulum lumen]
(Canis familiaris)
MTTP [endoplasmic reticulum lumen]
(Gallus gallus)
MTTP [endoplasmic reticulum lumen]
(Sus scrofa)
dsc-4 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Mttp [endoplasmic reticulum lumen]
(Mus musculus)
Mttp [endoplasmic reticulum lumen]
(Rattus norvegicus)
Mtp [endoplasmic reticulum lumen]
(Drosophila melanogaster)
Cross References
ZINC - World Drugs
MTP_HUMAN
ENSEMBL
ENSP00000265517
,
ENST00000457717
,
ENST00000422897
,
ENSP00000407350
,
ENSP00000400821
,
ENST00000265517
OpenTargets
ENSG00000138823
ZINC - FDA approved
MTP_HUMAN
ZINC - Substances
MTP_HUMAN
ZINC target
P55157
PRO
P55157
GlyGen
P55157
PDB
8EOJ
ZINC - Investigational
MTP_HUMAN
HPA
ENSG00000138823-MTTP
Pharos - Targets
P55157
Orphanet
MTTP
ZINC - Predictions - Purchasable
MTP_HUMAN
HMDB Protein
HMDBP01619
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04114 APOB
20
APOB(28-2179) [cytosol]
(R-HSA-2395786)
APOB(28-2179) [early endosome]
(R-HSA-2429651)
APOB(28-4563) [lysosomal lumen]
(R-HSA-8876369)
APOB(28-2179) [endosome lumen]
(R-HSA-174716)
APOB(28-2179) [endosome membrane]
(R-HSA-174762)
APOB(28-4563) [plasma membrane]
(R-HSA-171089)
APOB(28-4563) [clathrin-coated endocytic vesicle membrane]
(R-HSA-171155)
APOB(28-4563) [endosome lumen]
(R-HSA-171119)
APOB(28-4563) [endosome membrane]
(R-HSA-171121)
APOB(28-2179) [clathrin-coated endocytic vesicle membrane]
(R-HSA-174788)
APOB(28-2179) [plasma membrane]
(R-HSA-174625)
APOB(28-4563) [extracellular region]
(R-HSA-171065)
10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [extracellular region]
(R-HSA-2173702)
APOB(28-4563) [endoplasmic reticulum membrane]
(R-HSA-6784882)
p-APOB(28-4563) [endoplasmic reticulum lumen]
(R-HSA-8957068)
AcK-APOB(28-4563) [extracellular region]
(R-HSA-2173751)
AcK-APOB(28-4563) [endocytic vesicle lumen]
(R-HSA-2239446)
10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [endocytic vesicle lumen]
(R-HSA-2239461)
APOB(28-4563) [endocytic vesicle lumen]
(R-HSA-2512789)
APOB(28-4563) [smooth endoplasmic reticulum]
(R-HSA-8866317)
0.697
4
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