Reactome | TERF2IP [nucleoplasm]

TERF2IP [nucleoplasm]

Stable Identifier

R-HSA-174873

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RAP1

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular Senescence (Homo sapiens)
    - DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
      - Telomere shortening during replicative exhaustion (Homo sapiens)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        TERF2IP [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        TERF2IP [nucleoplasm] (Homo sapiens)

Reproduction (Homo sapiens)

- Meiosis (Homo sapiens)
  - Meiotic synapsis (Homo sapiens)
    - Telomeres cluster at the nuclear membrane (Homo sapiens)
      - Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        TERF2IP [nucleoplasm] (Homo sapiens)
      - Telomere Attachment Plate [nuclear envelope] (Homo sapiens)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        TERF2IP [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NYB0 TERF2IP

Gene Names

TERF2IP, DRIP5, RAP1, PP8000

Chain

initiator methionine:, chain:2-399

Reference Genes

BioGPS Gene:54386 TERF2IP

COSMIC (genes):TERF2IP TERF2IP

CTD Gene:54386 TERF2IP

dbSNP Gene:54386 TERF2IP

ENSEMBL:ENSG00000166848 TERF2IP

HGNC:19246 TERF2IP

KEGG:hsa:54386 TERF2IP

Monarch:54386 TERF2IP

NCBI Gene:54386 TERF2IP

OMIM:605061 TERF2IP

UCSC:Q9NYB0 TERF2IP

Reference Transcript

RefSeq:NM_018975.3 TERF2IP

Other Identifiers

11757968_s_at

16821083

16821089

201174_PM_s_at

201174_s_at

3669094

3669095

3669096

3669097

3669098

3669099

3669104

3669106

3669107

3669108

3669109

3669110

3669122

3669123

38982_at

3936148

54386

77482_at

78205_at

7997281

A_21_P0008971

A_23_P129704

GE589567

GE61445

GO:0000228

GO:0000723

GO:0000781

GO:0000783

GO:0001673

GO:0001933

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006355

GO:0007004

GO:0010569

GO:0010833

GO:0016233

GO:0016604

GO:0019902

GO:0031848

GO:0032200

GO:0032204

GO:0032205

GO:0032206

GO:0035556

GO:0042162

GO:0043123

GO:0043226

GO:0048239

GO:0051092

GO:0070187

GO:0070198

GO:0098505

GO:1901224

HMNXSV003014981

HMNXSV003021857

ILMN_1657983

PH_hs_0032420

TC16000621.hg

TC16001643.hg

g9507032_3p_s_at

p20082

Participates

as a component of

Inferred To

TERF2IP [nucleoplasm] (Bos taurus)

TERF2IP [nucleoplasm] (Canis familiaris)

TERF2IP [nucleoplasm] (Gallus gallus)

TERF2IP [nucleoplasm] (Sus scrofa)

Terf2ip [nucleoplasm] (Mus musculus)

Terf2ip [nucleoplasm] (Rattus norvegicus)

terf2ip [nucleoplasm] (Xenopus tropicalis)

rap1 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_061848.2

OpenTargets

ENSG00000166848

ENSEMBL

ENST00000300086, ENSP00000300086

HPA

ENSG00000166848-TERF2IP

PRO

Q9NYB0

Pharos - Targets

Q9NYB0

Orphanet

TERF2IP

GlyGen

Q9NYB0

PDB

4RQI, 1FEX, 3K6G, 7OZ0

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NUX5 POT1	1	POT1 [nucleoplasm] (R-HSA-174890)	0.725	6
UniProt:P56559 ARL4C	1	ARL4C [plasma membrane] (R-HSA-9618406)	0.527	2
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.508	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.508	2
UniProt:P37837 TALDO1	4	TALDO1 R192C [cytosol] (R-HSA-5659976) TALDO1 R192H [cytosol] (R-HSA-5659979) TALDO1 S171F [cytosol] (R-HSA-5659977) TALDO1 [cytosol] (R-HSA-71325)	0.508	2
UniProt:P18510 IL1RN	1	IL1RN [plasma membrane] (R-HSA-445743)	0.508	2
UniProt:O95848 NUDT14	1	NUDT14 [cytosol] (R-HSA-6809220)	0.508	2
UniProt:Q9UQN3 CHMP2B	2	CHMP2B [endosome membrane] (R-HSA-9631179) CHMP2B [cytosol] (R-HSA-917695)	0.508	2
UniProt:Q92620 DHX38	1	DHX38 [nucleoplasm] (R-HSA-72060)	0.508	2
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.508	2
UniProt:P14550 AKR1A1	1	AKR1A1 [cytosol] (R-HSA-5661253)	0.508	2
UniProt:O75347 TBCA	1	TBCA [cytosol] (R-HSA-379538)	0.508	2
UniProt:Q15121 PEA15	1	PEA15 [cytosol] (R-HSA-5675204)	0.508	2
UniProt:P25713 MT3	1	MT3 [cytosol] (R-HSA-5660396)	0.508	2
UniProt:Q9BXM0 PRX	1	PRX [plasma membrane] (R-HSA-9619341)	0.508	2
UniProt:Q9NZ63 C9orf78	1	C9orf78 [nucleoplasm] (R-HSA-9769588)	0.508	2
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.508	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.508	2
UniProt:Q9NWV8 BABAM1	2	BABAM1 [cytosol] (R-HSA-5691418) BABAM1 [nucleoplasm] (R-HSA-5682582)	0.508	2
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.508	2
UniProt:O95336 PGLS	1	PGLS [cytosol] (R-HSA-71294)	0.508	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.508	2
UniProt:P80297 MT1X	1	MT1X [cytosol] (R-HSA-5660400)	0.508	2

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