Reactome | TINF2 [nucleoplasm]

TINF2 [nucleoplasm]

Stable Identifier

R-HSA-174883

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

TIN2

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular Senescence (Homo sapiens)
    - DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
      - Telomere shortening during replicative exhaustion (Homo sapiens)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        TINF2 [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        TINF2 [nucleoplasm] (Homo sapiens)

Reproduction (Homo sapiens)

- Meiosis (Homo sapiens)
  - Meiotic synapsis (Homo sapiens)
    - Telomeres cluster at the nuclear membrane (Homo sapiens)
      - Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        TINF2 [nucleoplasm] (Homo sapiens)
      - Telomere Attachment Plate [nuclear envelope] (Homo sapiens)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        TINF2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BSI4 TINF2

Gene Names

TINF2, TIN2

Chain

initiator methionine:1, chain:2-451

Reference Genes

BioGPS Gene:26277 TINF2

COSMIC (genes):TINF2 TINF2

CTD Gene:26277 TINF2

dbSNP Gene:26277 TINF2

ENSEMBL:ENSG00000092330 TINF2

HGNC:11824 TINF2

KEGG:hsa:26277 TINF2

Monarch:26277 TINF2

NCBI Gene:26277 TINF2

OMIM:604319 TINF2

UCSC:Q9BSI4 TINF2

Reference Transcript

Participates

as a component of

Inferred To

Ghost homologue of TINF2 [nucleoplasm] (Gallus gallus)

Tinf2 [nucleoplasm] (Mus musculus)

Tinf2 [nucleoplasm] (Rattus norvegicus)

TINF2 [nucleoplasm] (Bos taurus)

TINF2 [nucleoplasm] (Canis familiaris)

TINF2 [nucleoplasm] (Sus scrofa)

tinf2 [nucleoplasm] (Danio rerio)

tinf2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001092744.1, NP_036593.2

ENSEMBL

ENST00000646576, ENST00000399423, ENSP00000494089, ENSG00000092330, ENST00000267415, ENSP00000382350, ENSG00000284915, ENST00000642983, ENSP00000267415, ENSP00000495019

OpenTargets

ENSG00000092330

GeneCards

TINF2

HPA

ENSG00000092330-TINF2

PRO

Q9BSI4

Pharos - Targets

Q9BSI4

Orphanet

TINF2

PDB

5XYF, 3BU8, 3BQO

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NUX5 POT1	1	POT1 [nucleoplasm] (R-HSA-174890)	0.738	6
UniProt:P05771 PRKCB	5	p-T500,T642,S661-PRKCB [cytosol] (R-HSA-5218706) p-T500-PRKCB [cytosol] (R-HSA-5218728) PRKCB [cytosol] (R-HSA-58198) PRKCB [plasma membrane] (R-HSA-156467) p-T500,T642,S661-PRKCB [nucleoplasm] (R-HSA-5223294)	0.508	2
UniProt:P52565 ARHGDIA	1	ARHGDIA [cytosol] (R-HSA-194478)	0.508	2
UniProt:P07437 TUBB	3	TUBB [extracellular region] (R-HSA-380317) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [cytosol] (R-HSA-9020816)	0.508	2
UniProt:P08865 RPSA	3	RPSA [cytosol] (R-HSA-72389) RPSA [plasma membrane] (R-HSA-9922472) RPSA [nucleoplasm] (R-HSA-6798722)	0.508	2
UniProt:P23588 EIF4B	2	p-S422-EIF4B [cytosol] (R-HSA-165773) EIF4B [cytosol] (R-HSA-72589)	0.508	2
UniProt:P60709 ACTB	5	ACTB [plasma membrane] (R-HSA-196016) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462)	0.508	2
UniProt:O60907 TBL1X	1	TBL1X [nucleoplasm] (R-HSA-351644)	0.508	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.508	2
UniProt:P50542 PEX5	4	PEX5 [cytosol] (R-HSA-9033132) PEX5 [peroxisomal membrane] (R-HSA-9665164) Ub-p-PEX5 [peroxisomal membrane] (R-HSA-9665183) p-PEX5 [peroxisomal membrane] (R-HSA-9665182)	0.508	2
UniProt:P14618 PKM	4	PKM [nucleoplasm] (R-HSA-9931500) PKM [secretory granule lumen] (R-HSA-6801401) PKM [extracellular region] (R-HSA-6806491) PKM [ficolin-1-rich granule lumen] (R-HSA-6801387)	0.508	2
UniProt:O43602 DCX	1	DCX [cytosol] (R-HSA-430060)	0.508	2

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