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About
What is Reactome ?
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Team
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
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ACD [nucleoplasm]
Stable Identifier
R-HSA-174889
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PTOP, TPP1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
Disassociation of Processive Complex and Completed Telomere End (Homo sapiens)
Extended And Processed Telomere End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Polymerase switching on the C-strand of the telomere (Homo sapiens)
Formation of Processive Complex on the C-strand of the telomere (Homo sapiens)
Processive complex loaded on telomere [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
RFC binding displaces Pol Alpha on the C-strand of the telomere (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
RFC dissociates after sliding clamp formation on the C-strand of the telomere (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Processive synthesis on the C-strand of the telomere (Homo sapiens)
Formation of C-strand Okazaki fragments (Homo sapiens)
Processive complex loaded on telomere [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Formation of the Flap Intermediate on the C-strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Joining of adjacent Okazaki fragments of the C-strand (Homo sapiens)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Removal of the Flap Intermediate from the C-strand (Homo sapiens)
RPA binds to the Flap on the C-strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Recruitment of DNA2 endonuclease to the C strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Removal of remaining Flap from the C-strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Telomere C-strand synthesis initiation (Homo sapiens)
DNA polymerase:primase binds G-strand of the telomere (Homo sapiens)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Homo sapiens)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Homo sapiens)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Telomere Extension By Telomerase (Homo sapiens)
Alignment Of The RNA Template On The Telomeric Chromosome End (Homo sapiens)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
CDK2:CCNA phosphorylates TERF2 (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
Shelterin complex (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Disassociation of Telomerase RNP and the Chromosome End (Homo sapiens)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Elongation Of The Telomeric Chromosome End (Homo sapiens)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Elongation of Extended Telomeric Chromosome End (Homo sapiens)
Telomerase Holoenzyme Base-paired to the Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
PP6-PPP6R3 dephosphorylates TERF2 (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
Shelterin complex (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Recruitment of Telomerase RNP to the Telomeric Chromosome End (Homo sapiens)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Homo sapiens)
Telomerase Holoenzyme Base-paired to the Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Inhibition of DNA recombination at telomere (Homo sapiens)
ATRX:DAXX binds to subtelomeric chromosomal regions (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Telomere:Shelterin:Nucleosome:ATRX:DAXX [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Histone H3.3 deposition at telomere (Homo sapiens)
Telomere:Shelterin:Nucleosome (H3F3A):ATRX:DAXX [nucleoplasm] (Homo sapiens)
Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Telomere:Shelterin:Nucleosome:ATRX:DAXX [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
TERRA transcription (Homo sapiens)
Telomere:Shelterin:Nucleosome (H3F3A):ATRX:DAXX [nucleoplasm] (Homo sapiens)
Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Packaging Of Telomere Ends (Homo sapiens)
Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Homo sapiens)
Extended And Processed Telomere End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic synapsis (Homo sapiens)
Telomeres cluster at the nuclear membrane (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Telomere Attachment Plate [nuclear envelope] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
Telomere shortening during replicative exhaustion (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Base-Excision Repair, AP Site Formation (Homo sapiens)
Depurination (Homo sapiens)
Cleavage of the damaged purine (Homo sapiens)
NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Homo sapiens)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA (Homo sapiens)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
NEIL3:Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Recognition and association of DNA glycosylase with site containing an affected purine (Homo sapiens)
NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Homo sapiens)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
NEIL3 recognizes and binds to spiroiminodihydantoin in telomeric DNA (Homo sapiens)
NEIL3:Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Depyrimidination (Homo sapiens)
Cleavage of the damaged pyrimidine (Homo sapiens)
NEIL3 cleaves thymine glycol from telomeric DNA (Homo sapiens)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
NEIL3:Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Homo sapiens)
NEIL3 recognizes and binds to thymine glycol in telomeric DNA (Homo sapiens)
NEIL3:Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic synapsis (Homo sapiens)
Telomeres cluster at the nuclear membrane (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
Telomere Attachment Plate [nuclear envelope] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
ACD [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96AP0 ACD
Gene Names
ACD, PIP1, PTOP, TINT1, TPP1
Chain
chain:1-458
Reference Genes
BioGPS Gene:65057 ACD
COSMIC (genes):ACD ACD
COSMIC (genes):TPP1 ACD
CTD Gene:65057 ACD
dbSNP Gene:65057 ACD
ENSEMBL:ENSG00000102977 ACD
HGNC:25070 ACD
KEGG:hsa:65057 ACD
Monarch:65057 ACD
NCBI Gene:65057 ACD
OMIM:609377 ACD
UCSC:Q96AP0 ACD
Reference Transcript
RefSeq:NM_001082487.1 ACD
RefSeq:NM_022914.2 ACD
RefSeq:NM_001082486.1 ACD
Other Identifiers
11718424_at
11748894_a_at
11761411_at
16827394
204617_PM_s_at
204617_s_at
3695788
3695789
3695790
3695791
3695792
3695793
3695794
3695795
3695796
3695797
3695798
3695799
3695800
3695801
3695802
3695803
3695804
3695805
3695806
3695807
3695808
3695809
3695810
3695811
3695812
3695813
3695814
3695815
3695816
3695817
3695818
37246_at
65057
8002057
A_23_P26375
A_33_P3359071
GE54627
GO:0000723
GO:0000781
GO:0000783
GO:0001501
GO:0001655
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005697
GO:0006886
GO:0007004
GO:0010521
GO:0016233
GO:0016604
GO:0030326
GO:0031848
GO:0032200
GO:0032202
GO:0032206
GO:0032211
GO:0035282
GO:0042162
GO:0043226
GO:0044877
GO:0048856
GO:0051973
GO:0060381
GO:0070182
GO:0070187
GO:0070198
GO:0070200
GO:0070203
GO:0098772
HMNXSV003037879
HMNXSV003049256
HMNXSV003057236
ILMN_1716480
PH_hs_0004505
TC16001193.hg
g12597658_3p_a_at
Participates
as a component of
Shelterin complex (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
Inferred To
Acd [nucleoplasm]
(Mus musculus)
Acd [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of ACD [nucleoplasm]
(Gallus gallus)
Ghost homologue of ACD [nucleoplasm]
(Schizosaccharomyces pombe)
acd [nucleoplasm]
(Xenopus tropicalis)
ACD [nucleoplasm]
(Bos taurus)
ACD [nucleoplasm]
(Canis familiaris)
ACD [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_075065.2
,
NP_001075956.1
,
NP_001075955.1
OpenTargets
ENSG00000102977
ENSEMBL
ENSP00000478084
,
ENST00000219251
,
ENSP00000219251
,
ENST00000620761
HPA
ENSG00000102977-ACD
PRO
Q96AP0
Pharos - Targets
Q96AP0
Orphanet
ACD
PDB
5H65
,
5I2X
,
5I2Y
,
8SOJ
,
7QXB
,
7QXA
,
5XYF
,
7TRE
,
5UN7
,
7QXS
,
8SOK
,
2I46
,
7S1T
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NUX5 POT1
1
POT1 [nucleoplasm]
(R-HSA-174890)
0.921
11
UniProt:Q91WC1 Pot1
2
Protection of telomeres protein 1 [nucleoplasm]
(R-MMU-912386)
Pot1 [nucleoplasm]
(R-MMU-174890)
0.589
3
UniProt:Q93009 USP7
2
USP7 [nucleoplasm]
(R-HSA-3215278)
USP7 [cytosol]
(R-HSA-8853511)
0.547
2
UniProt:Q92900 UPF1
2
p-4S-UPF1 [cytosol]
(R-HSA-927856)
UPF1 [cytosol]
(R-HSA-927734)
0.524
3
UniProt:P07476 IVL
2
IVL [cornified envelope]
(R-HSA-8847720)
IVL [cytosol]
(R-HSA-6810837)
0.508
2
UniProt:O00410 IPO5
1
IPO5 [nucleoplasm]
(R-HSA-192675)
0.508
2
UniProt:Q9H668 STN1
1
STN1 [nucleoplasm]
(R-HSA-9668821)
0.508
4
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.508
2
UniProt:Q9BTW9 TBCD
1
TBCD [cytosol]
(R-HSA-379540)
0.508
2
UniProt:Q9UJU6 DBNL
7
DBNL [ficolin-1-rich granule lumen]
(R-HSA-6801510)
DBNL [tertiary granule lumen]
(R-HSA-6801516)
DBNL [extracellular region]
(R-HSA-6801604)
DBNL [secretory granule lumen]
(R-HSA-6801520)
DBNL(1-361) [cytosol]
(R-HSA-202925)
DBNL(362-431) [cytosol]
(R-HSA-202933)
DBNL [cytosol]
(R-HSA-202880)
0.508
2
UniProt:O43768 ENSA
2
ENSA [nucleoplasm]
(R-HSA-2160964)
p-S67-ENSA [nucleoplasm]
(R-HSA-2430532)
0.508
2
UniProt:Q9BXI6 TBC1D10A
2
TBC1D10A [cytosol]
(R-HSA-8854139)
TBC1D10A [microvillus]
(R-HSA-8854143)
0.508
2
UniProt:P31948 STIP1
1
STIP1 [cytosol]
(R-HSA-443857)
0.508
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.508
2
UniProt:Q9H477 RBKS
1
RBKS [cytosol]
(R-HSA-8955847)
0.508
2
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