The acetyl group from acetyl-CoA is transferred to the NAT1

Stable Identifier
R-HSA-174959
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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The acetyl group from acetyl-CoA is transferred to the NAT1
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
N-acetylation occurs in two sequential steps via a ping-pong Bi-Bi mechanism. In the first step, the acetyl group from acetyl-CoA is transferred to a conserved cysteine residue (position 68) in the active site of NAT, with consequent release of coenzyme-A. In the second step, the acetyl group is transferred to the acceptor substrate and the enzyme returns to its initial state.
Literature References
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Orthologous Events
The acetyl group from acetyl-CoA is transferred to the NAT1 (Bos taurus)
The acetyl group from acetyl-CoA is transferred to the NAT1 (Danio rerio)
The acetyl group from acetyl-CoA is transferred to the NAT1 (Gallus gallus)
The acetyl group from acetyl-CoA is transferred to the NAT1 (Mus musculus)
The acetyl group from acetyl-CoA is transferred to the NAT1 (Rattus norvegicus)
The acetyl group from acetyl-CoA is transferred to the NAT1 (Sus scrofa)
Authored
Jassal, B  (2005-02-09)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2006-02-23)
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