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COMT [cytosol]
Stable Identifier
R-HSA-175974
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Catechol O-methyltransferase
Locations in the PathwayBrowser for interactor UniProt:Q9Y6D0 SELK
Expand all
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase II - Conjugation of compounds (Homo sapiens)
Methylation (Homo sapiens)
COMT transfer CH3 from AdoMet to 3,4DHBNZ (Homo sapiens)
COMT [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21964 COMT
Gene Names
COMT
Chain
chain:1-271
Reference Genes
COSMIC (genes):COMT COMT
dbSNP Gene:1312 COMT
ENSEMBL:ENSG00000093010 COMT
Other forms of this molecule
COMT [plasma membrane]
Inferred To
Homologues of COMT [cytosol]
(Schizosaccharomyces pombe)
COMT [cytosol]
(Bos taurus)
COMT [cytosol]
(Canis familiaris)
COMT [cytosol]
(Danio rerio)
COMT [cytosol]
(Gallus gallus)
COMT [cytosol]
(Mus musculus)
COMT [cytosol]
(Rattus norvegicus)
COMT [cytosol]
(Schizosaccharomyces pombe)
COMT [cytosol]
(Sus scrofa)
COMT [cytosol]
(Xenopus tropicalis)
Interactors (60)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6UW68 TM205
0.666
4
UniProt:Q15645 PCH2
0.621
3
UniProt:Q9NTQ9 GJB4
1
GJB4 [endoplasmic reticulum membrane]
(R-HSA-190624)
0.556
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q9NY26 SLC39A1
1
SLC39A1 [plasma membrane]
(R-HSA-442329)
0.556
3
UniProt:Q5T1Q4 S35F1
0.556
3
UniProt:O95183 VAMP5
0.556
3
UniProt:O00258 GET1
1
WRB [endoplasmic reticulum membrane]
(R-HSA-9609521)
0.556
3
UniProt:B2RUZ4 SMIM1
0.556
3
UniProt:P30518 AVPR2
3
AVPR2 [plasma membrane]
(R-HSA-388431)
p-AVPR2 [plasma membrane]
(R-HSA-8866009)
AVPR2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869077)
0.556
3
UniProt:Q15836 VAMP3
6
VAMP3 [recycling endosome membrane]
(R-HSA-2029063)
VAMP3 [phagocytic vesicle membrane]
(R-HSA-2029013)
VAMP3 [plasma membrane]
(R-HSA-8867599)
VAMP3 [trans-Golgi network membrane]
(R-HSA-6814624)
VAMP3 [transport vesicle]
(R-HSA-6814625)
VAMP3 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869130)
0.556
3
UniProt:Q8TDT2 GP152
0.556
3
UniProt:Q9UHJ9-5 PGAP2
0.556
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
UniProt:O60669 SLC16A7
1
SLC16A7 [plasma membrane]
(R-HSA-373955)
0.556
3
UniProt:P22732 SLC2A5
2
SLC2A5 [specific granule membrane]
(R-HSA-6799571)
SLC2A5 [plasma membrane]
(R-HSA-189202)
0.556
3
UniProt:O14843 FFAR3
1
FFAR3 [plasma membrane]
(R-HSA-443951)
0.556
3
UniProt:Q8N6U8 GPR161
2
GPR161 [ciliary membrane]
(R-HSA-5610373)
GPR161 [endocytic vesicle membrane]
(R-HSA-5635021)
0.556
3
UniProt:Q14656 TM187
0.556
3
UniProt:Q8NFU1 BEST2
1
BEST2 [plasma membrane]
(R-HSA-2744359)
0.556
3
UniProt:Q9H2F3 HSD3B7
1
HSD3B7 [endoplasmic reticulum membrane]
(R-HSA-193441)
0.556
3
UniProt:P30825 SLC7A1
1
SLC7A1 [plasma membrane]
(R-HSA-375771)
0.556
3
UniProt:Q96MV1 TLCD4
0.556
3
UniProt:O95279 KCNK5
1
KCNK5 [plasma membrane]
(R-HSA-1296323)
0.556
3
UniProt:Q9P0S9 TM14C
0.556
3
UniProt:Q99500 S1PR3
1
S1PR3 [plasma membrane]
(R-HSA-419396)
0.556
3
UniProt:Q9Y6D0 SELK
0.556
3
UniProt:P34981 TRHR
1
TRHR [plasma membrane]
(R-HSA-444556)
0.556
3
UniProt:Q5SR56 MF14B
0.556
3
UniProt:Q3KNW5 SLC10A6
1
SLC10A6 [plasma membrane]
(R-HSA-433091)
0.556
3
UniProt:Q0D2K0 NIPAL4
1
NIPAL4 [plasma membrane]
(R-HSA-5216046)
0.556
3
UniProt:O15529 GPR42
0.556
3
UniProt:Q9NUH8 TM14B
0.556
3
UniProt:Q9UPZ6 THSD7A
3
THSD7A [endoplasmic reticulum lumen]
(R-HSA-5173009)
glc-fuc-THSD7A [endoplasmic reticulum lumen]
(R-HSA-5173197)
O-fuc-THSD7A [endoplasmic reticulum lumen]
(R-HSA-5173184)
0.556
3
UniProt:A6NDP7 MADL2
0.556
3
UniProt:O95807 TM50A
0.556
3
UniProt:Q8NHW4 CCL4L1
1
CCL4L1 [extracellular region]
(R-HSA-8865389)
0.556
3
UniProt:O75712 GJB3
2
GJB3 [plasma membrane]
(R-HSA-9839595)
GJB3 [endoplasmic reticulum membrane]
(R-HSA-190625)
0.556
3
UniProt:P34972 CNR2
1
CNR2 [plasma membrane]
(R-HSA-419372)
0.556
3
UniProt:Q9NV29 TM100
0.556
3
UniProt:A0PK00 T120B
0.556
3
UniProt:Q6P1K1 HRG1
0.556
3
UniProt:Q9H0R3 TM222
0.556
3
UniProt:Q8IY26 PLPP6
1
PLPP6 [plasma membrane]
(R-HSA-8952144)
0.556
3
UniProt:Q96G79 S35A4
0.556
3
UniProt:P31937 HIBADH
1
HIBADH [mitochondrial matrix]
(R-HSA-70882)
0.556
3
UniProt:P50402 EMD
4
EMD [nuclear envelope]
(R-HSA-201573)
EMD [cytosol]
(R-HSA-9613988)
EMD [endoplasmic reticulum membrane]
(R-HSA-9613998)
EMD [endosome membrane]
(R-HSA-9715092)
0.556
3
UniProt:Q5JX71 F209A
0.556
3
UniProt:Q9UHI5 SLC7A8
1
SLC7A8 [plasma membrane]
(R-HSA-352156)
0.556
3
UniProt:Q7RTS5 OTOP3
0.556
3
UniProt:Q9NP94 SLC39A2
1
SLC39A2 [plasma membrane]
(R-HSA-442395)
0.556
3
UniProt:Q9H6H4 REEP4
0.556
3
UniProt:Q6NTF9-3 Q6NTF93
0.556
3
UniProt:O75783 RHBL1
0.556
3
UniProt:O95377 GJB5
1
GJB5 [endoplasmic reticulum membrane]
(R-HSA-190643)
0.556
3
UniProt:Q6P5T0 Q6P5T0
0.556
3
UniProt:P08034 GJB1
2
GJB1 [endoplasmic reticulum membrane]
(R-HSA-190656)
GJB1 [endoplasmic reticulum-Golgi intermediate compartment]
(R-HSA-190636)
0.556
3
UniProt:P0DTD1-PRO_0000449625 REP
0.527
2
UniProt:P0DTD8 NS7B
0.527
2
UniProt:P12520 VPR
0.462
2
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