GST trimers transfer GS from GSH to luminal substrates

Stable Identifier
R-HSA-176059
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
Synonyms
MGST trimers conjugate GSH with luminal substrates
ReviewStatus
5/5
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GST trimers transfer GS from GSH to luminal substrates
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The microsomal glutathione S-transferases (MGSTs) catalyse the nucleophilic attack by reduced glutathione (GSH) on nonpolar compounds that contain an electrophilic C, N, or S atom. Three major families of proteins are widely distributed in nature. The cytosolic and mitochondrial GST families comprise soluble enzymes that are only distantly related whilst the third family comprises microsomal GST, referred to as membrane-associated proteins in eicosanoid and glutathione (MAPEG) metabolism. Three members of this family function as detoxification enzymes, MGST1-3 (DeJong et al. 1988, Kelner et al. 1996, Jakobsson et al. 1996, Jakobsson et al. 1997). Electron crystallography studies in rat Mgst1 indicate these enzymes function as homotrimers (Holm et al. 2002). Both aflatoxin B1 exo- and endo-epoxides (AFXBO and AFNBO) conjugate with glutathione. These conjugates are eventually excreted in urine as mercapturic acids.
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as an event of
Catalyst Activity

glutathione transferase activity of MGST trimers [endoplasmic reticulum membrane]

Physical Entity
MGST trimers [endoplasmic reticulum membrane] (Homo sapiens)
Activity
glutathione transferase activity (GO:0004364)
Orthologous Events
GST trimers transfer GS from GSH to luminal substrates (Bos taurus)
GST trimers transfer GS from GSH to luminal substrates (Canis familiaris)
GST trimers transfer GS from GSH to luminal substrates (Danio rerio)
GST trimers transfer GS from GSH to luminal substrates (Dictyostelium discoideum)
GST trimers transfer GS from GSH to luminal substrates (Drosophila melanogaster)
GST trimers transfer GS from GSH to luminal substrates (Gallus gallus)
GST trimers transfer GS from GSH to luminal substrates (Mus musculus)
GST trimers transfer GS from GSH to luminal substrates (Rattus norvegicus)
GST trimers transfer GS from GSH to luminal substrates (Sus scrofa)
GST trimers transfer GS from GSH to luminal substrates (Xenopus tropicalis)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2006-03-02)
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