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RAD1 [nucleoplasm]
Stable Identifier
R-HSA-176382
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
Activation of ATR in response to replication stress (Homo sapiens)
Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
G2/M DNA damage checkpoint (Homo sapiens)
ATR phosphorylates TP53 (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
Homologous DNA Pairing and Strand Exchange (Homo sapiens)
Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
RAD51 binds BRCA2 at resected DNA DSBs (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
HDR through Single Strand Annealing (SSA) (Homo sapiens)
Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
Association of RAD52 with the RPA complex at resected DNA DSBs (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
RAD52 promotes single strand annealing at resected DNA DSBs (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
Processing of DNA double-strand break ends (Homo sapiens)
ATR activation at DNA DSBs (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
ATR phosphorylates RPA2 (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
Activation of CHEK1 at resected DNA DSBs (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
CHEK1 is recruited to resected DNA DSBs (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of DNA repair (Homo sapiens)
Diseases of DNA Double-Strand Break Repair (Homo sapiens)
Defective homologous recombination repair (HRR) due to BRCA2 loss of function (Homo sapiens)
Impaired BRCA2 binding to RAD51 (Homo sapiens)
BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51 (Homo sapiens)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
ATR phosphorylates TP53 (Homo sapiens)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
RAD1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60671 RAD1
Gene Names
RAD1, REC1
Chain
chain:1-282
Reference Genes
BioGPS Gene:5810 RAD1
COSMIC (genes):RAD1 RAD1
CTD Gene:5810 RAD1
dbSNP Gene:5810 RAD1
ENSEMBL:ENSG00000113456 RAD1
ENSEMBL_homo_sapiens_GENE:ENSG00000113456.20 RAD1
HGNC:9806 RAD1
KEGG Gene (Homo sapiens):5810 RAD1
Monarch:5810 RAD1
NCBI Gene:5810 RAD1
OMIM:603153 RAD1
UCSC:O60671 RAD1
Reference Transcript
RefSeq:NM_002853.3 RAD1
Other Identifiers
11722868_a_at
11722869_a_at
11722870_at
11750906_at
11750907_x_at
11758046_s_at
16995140
204460_PM_s_at
204460_s_at
204461_PM_x_at
204461_x_at
210216_PM_x_at
210216_x_at
228535_PM_at
228535_at
235253_PM_at
235253_at
2852995
2852996
2852997
2852998
2852999
2853000
2853001
2853002
2853003
2853004
2853005
2853006
2853007
2853009
2853010
2853013
2853016
2853017
2853018
2853020
2853022
2853023
2853024
3267310
3267311
36857_at
50930_at
5810
8111457
90897_at
A_23_P144697
A_33_P3272828
GE54242
GO:0000077
GO:0000228
GO:0003677
GO:0003684
GO:0003824
GO:0004518
GO:0004527
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006281
GO:0006974
GO:0008311
GO:0008408
GO:0016787
GO:0021762
GO:0022414
GO:0023052
GO:0030896
GO:0043226
GO:0043231
GO:0048856
GO:0051598
GO:0071479
GO:0140013
GO:0140097
HMNXSV003024165
HMNXSV003044000
Hs.261727.0.A1_3p_at
Hs.34392.0.A1_3p_at
Hs.34392.0.A1_3p_x_at
ILMN_1737635
ILMN_1763765
PH_hs_0000735
TC05001259.hg
TC05002949.hg
g3309650_3p_a_at
Participates
as a component of
RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
Inferred To
RAD1 [nucleoplasm]
(Bos taurus)
RAD1 [nucleoplasm]
(Canis familiaris)
RAD1 [nucleoplasm]
(Gallus gallus)
RAD1 [nucleoplasm]
(Sus scrofa)
Rad1 [nucleoplasm]
(Drosophila melanogaster)
Rad1 [nucleoplasm]
(Mus musculus)
Rad1 [nucleoplasm]
(Rattus norvegicus)
mrt-2 [nucleoplasm]
(Caenorhabditis elegans)
rad1 [nucleoplasm]
(Dictyostelium discoideum)
rad1 [nucleoplasm]
(Schizosaccharomyces pombe)
rad1 [nucleoplasm]
(Xenopus tropicalis)
RAD17 [nucleoplasm]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_002844.1
OpenTargets
ENSG00000113456
ZINC - Substances
RAD1_HUMAN
HPA
ENSG00000113456-RAD1
GeneCards
O60671
Ensembl
ENST00000325577
,
ENST00000382038
,
ENSP00000340879
,
ENSP00000371469
,
ENST00000341754
,
ENSP00000313467
,
ENSG00000113456
ZINC target
O60671
PRO
O60671
Pharos - Targets
O60671
ZINC - Predictions - Purchasable
RAD1_HUMAN
PDB
3A1J
,
6J8Y
,
8GNN
,
3G65
,
7Z6H
,
3GGR
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![RAD1 [nucleoplasm] icon](/icon/R-ICO-012378.svg){kind=icon}
