Phosphorylation of the APC/C

Stable Identifier
R-HSA-176412
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylation of the APC/C
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Phosphorylation of APC subunits is required for Cdc20 mediated activation by of the APC/C at the metaphase anaphase transition (Kramer et al., 2000). While the kinases responsible for phosphorylation in vivo have not been determined with certainty, both Plk1 and Cyclin B:Cdc2 have been implicated in this process.
Literature References
PubMed ID Title Journal Year
10793135 Mitotic regulation of the APC activator proteins CDC20 and CDH1

Podtelejnikov, AV, Scheuringer, N, Peters, JM, Kramer, ER, Mann, M

Mol Biol Cell 2000
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
regulation of mitotic cell cycle phase transition (1901990)
Orthologous Events
Phosphorylation of the APC/C (Bos taurus)
Phosphorylation of the APC/C (Canis familiaris)
Phosphorylation of the APC/C (Dictyostelium discoideum)
Phosphorylation of the APC/C (Drosophila melanogaster)
Phosphorylation of the APC/C (Gallus gallus)
Phosphorylation of the APC/C (Mus musculus)
Phosphorylation of the APC/C (Rattus norvegicus)
Phosphorylation of the APC/C (Sus scrofa)
Phosphorylation of the APC/C (Xenopus tropicalis)
Cross References
BioModels Database
Reviewed
Peters, JM  (2006-03-28)
Created
Matthews, L  (2006-03-08)
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