Reactome | 3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP

3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP

Stable Identifier

R-HSA-176474

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP

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Six SULT enzymes, SULT1A1 (Li et al. 2001), 1A3 (Kester, Kaptein et al. 1999), 1B1 (Wang et al. 1998), 1C1 (Li et al. 2000), 1E1 (Li and Anderson 1999; Kester, van Dijk et al. 1999), and 2A1 (Li and Anderson 1999), can catalyze the sulfonation of 3,3'-diiodothyronine (T2) in vitro or in tissue culture model systems. These six enzymes also catalyze the sulfonation of 3,5,3'-triiodothyronine (T3).

Literature References

PubMed ID	Title	Journal	Year
10512730	Sulfation of iodothyronines by recombinant human liver steroid sulfotransferases Anderson, RJ, Li, X	Biochem Biophys Res Commun	1999
9463486	Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver Falany, JL, Falany, CN, Wang, J	Mol Pharmacol	1998
11077054	Sulfation of iodothyronines by human sulfotransferase 1C1 (SULT1C1)* Anderson, RJ, Clemens, DL, Li, X	Biochem Pharmacol	2000
10199779	Characterization of human iodothyronine sulfotransferases Roest, TJ, Kaptein, E, van Dijk, CH, Glatt, H, Tibboel, D, Visser, TJ, Kester, MH, Coughtrie, MW, Meinl, W	J Clin Endocrinol Metab	1999
11739018	Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate Anderson, RJ, Clemens, DL, Li, X, Cole, JR	J Endocrinol	2001