SULTs transfer (SO4)2- group to 27HCHOL

Stable Identifier
R-HSA-176494
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Synonyms
27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP
ReviewStatus
5/5
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SULTs transfer (SO4)2- group to 27HCHOL
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The sulfonation of 27-hydroxycholesterol (27HCHOL) is catalyzed by both the a and b isoforms of SULT2B1 (Javitt et al. 2001).
Literature References
PubMed ID Title Journal Year
11416019 Cholesterol and hydroxycholesterol sulfotransferases: identification, distinction from dehydroepiandrosterone sulfotransferase, and differential tissue expression

Lee, YC, Fuda, H, Javitt, NB, Strott, CA, Shimizu, C

Endocrinology 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

alcohol sulfotransferase activity of SULTs active on 27HCHOL [cytosol]

Physical Entity
SULTs active on 27HCHOL [cytosol] (Homo sapiens)
Activity
alcohol sulfotransferase activity (GO:0004027)
Orthologous Events
SULTs transfer (SO4)2- group to 27HCHOL (Bos taurus)
SULTs transfer (SO4)2- group to 27HCHOL (Canis familiaris)
SULTs transfer (SO4)2- group to 27HCHOL (Danio rerio)
SULTs transfer (SO4)2- group to 27HCHOL (Drosophila melanogaster)
SULTs transfer (SO4)2- group to 27HCHOL (Gallus gallus)
SULTs transfer (SO4)2- group to 27HCHOL (Mus musculus)
SULTs transfer (SO4)2- group to 27HCHOL (Rattus norvegicus)
SULTs transfer (SO4)2- group to 27HCHOL (Sus scrofa)
SULTs transfer (SO4)2- group to 27HCHOL (Xenopus tropicalis)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
D'Eustachio, P  (2006-03-09)
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