Reactome | cholesterol + PAPS => cholesterol sulfate + PAP

cholesterol + PAPS => cholesterol sulfate + PAP

Stable Identifier

R-HSA-176609

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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cholesterol + PAPS => cholesterol sulfate + PAP

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The 3-hydroxyl groups of a number of sterols can undergo sulfonation. Cholesterol sulfate is particularly abundant in the body, and may have both regulatory and biosynthetic functions (Strott and Higashi 2003). Its synthesis is catalyzed by the b isoform of SULT2B1 (Fuda et al. 2002; Javitt et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
12145317	Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase Lee, YC, Fuda, H, Javitt, NB, Strott, CA, Shimizu, C	J Biol Chem	2002
11416019	Cholesterol and hydroxycholesterol sulfotransferases: identification, distinction from dehydroepiandrosterone sulfotransferase, and differential tissue expression Lee, YC, Fuda, H, Javitt, NB, Strott, CA, Shimizu, C	Endocrinology	2001
12730293	Cholesterol sulfate in human physiology: what's it all about? Higashi, Y, Strott, CA	J Lipid Res	2003