Reactome | N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP

N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP

Stable Identifier

R-HSA-176669

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP

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Sulfonation of the xenobiotic N-hydroxy-2-acetylaminofluorene converts it to a potent carcinogen. SULT1A2 (Glatt 2000) and SULT1C1 and 1C2 (Sakakibara et al. 1998) catalyze this reaction.

Literature References

PubMed ID	Title	Journal	Year
11154739	Sulfotransferases in the bioactivation of xenobiotics Glatt, H	Chem Biol Interact	2000
9852044	Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene Liu, MC, Nakayama, T, Ringer, DP, Suiko, M, Takami, Y, Sakakibara, Y, Katafuchi, J, Yanagisawa, K	J Biol Chem	1998