Unwinding of DNA

Stable Identifier
R-HSA-176974
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Unwinding of DNA
Click the image above or here to open this pathway in the Pathway Browser
DNA Replication is regulated accurately and precisely by various protein complexes. Many members of the MCM protein family are assembled into the pre-Replication Complexes (pre-RC) at the end of M phase of the cell cycle. DNA helicase activity of some of the MCM family proteins are important for the unwinding of DNA and initiation of replication processes. This section contains four events which have been proved in different eukaryotic experimental systems to involve various proteins for this essential step during DNA Replication.
Literature References
PubMed ID Title Journal Year
15707891 MCM8 is an MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation

Danis, E, Maiorano, D, Cuvier, O, Mechali, M

Cell 2005
10834843 Uninterrupted MCM2-7 function required for DNA replication fork progression.

Diffley, JF, Labib, K, Tercero, JA

Science 2000
Participants
Events
Participates
as an event of
Orthologous Events
Unwinding of DNA (Bos taurus)
Unwinding of DNA (Caenorhabditis elegans)
Unwinding of DNA (Canis familiaris)
Unwinding of DNA (Dictyostelium discoideum)
Unwinding of DNA (Drosophila melanogaster)
Unwinding of DNA (Mus musculus)
Unwinding of DNA (Rattus norvegicus)
Unwinding of DNA (Saccharomyces cerevisiae)
Unwinding of DNA (Schizosaccharomyces pombe)
Unwinding of DNA (Sus scrofa)
Authored
Tye, BK  (2006-03-17)
Created
Gopinathrao, G  (2006-03-18)
Cite Us!