Reactome | GINS2 [nucleoplasm]

GINS2 [nucleoplasm]

Stable Identifier

R-HSA-176975

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PSF2p

Locations in the PathwayBrowser for interactor UniProt:P57059 SIK1

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External Reference Information

External Reference

UniProt:Q9Y248 GINS2

Gene Names

GINS2, PSF2, CGI-122, DC5, HSPC037

Chain

chain:1-185

Reference Genes

BioGPS Gene:51659 GINS2

COSMIC (genes):GINS2 GINS2

CTD Gene:51659 GINS2

dbSNP Gene:51659 GINS2

ENSEMBL:ENSG00000131153 GINS2

HGNC:24575 GINS2

KEGG:hsa:51659 GINS2

Monarch:51659 GINS2

NCBI Gene:51659 GINS2

OMIM:610609 GINS2

UCSC:Q9Y248 GINS2

Reference Transcript

RefSeq:NM_016095.3 GINS2

Other Identifiers

11743513_a_at

1557595_PM_at

1557595_at

16828886

221521_PM_s_at

221521_s_at

243136_PM_at

243136_at

3703109

3703110

3703111

3703113

3703114

3703115

3703116

3703117

3703118

3703119

3703122

3703123

3703124

3703125

3703126

3703127

3703128

3905440

3905444

48827_at

51659

72598_at

73010_at

8003204

A_23_P118246

GE58679

GO:0000228

GO:0000727

GO:0000811

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006260

GO:0006281

GO:0006310

GO:0071162

Hs.222171.0.A1_3p_at

Hs2.429227.1.S1_3p_s_at

ILMN_1809590

PH_hs_0020095

TC16001318.hg

g13112024_3p_a_at

Participates

as a component of

GINS complex [nucleoplasm] (Homo sapiens)

as an input of

Formation of GINS complex (Homo sapiens)

Inferred To

psf2 [nucleoplasm] (Schizosaccharomyces pombe)

Gins2 [nucleoplasm] (Mus musculus)

Gins2 [nucleoplasm] (Rattus norvegicus)

Psf2 [nucleoplasm] (Drosophila melanogaster)

GINS2 [nucleoplasm] (Bos taurus)

GINS2 [nucleoplasm] (Canis familiaris)

GINS2 [nucleoplasm] (Gallus gallus)

GINS2 [nucleoplasm] (Sus scrofa)

gins2 [nucleoplasm] (Danio rerio)

gins2 [nucleoplasm] (Dictyostelium discoideum)

gins2 [nucleoplasm] (Xenopus tropicalis)

psf-2 [nucleoplasm] (Caenorhabditis elegans)

PSF2 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_057179.1

ENSEMBL

ENST00000253462, ENSP00000253462, ENSG00000131153

OpenTargets

ENSG00000131153

GeneCards

GINS2

HPA

ENSG00000131153-GINS2

PRO

Q9Y248

Pharos - Targets

Q9Y248

GlyGen

Q9Y248

PDB

8OK2, 6XTY, 8B9D, 6XTX, 2EHO, 2E9X, 2Q9Q, 7PLO, 7PFO

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BRT9 GINS4	1	GINS4 [nucleoplasm] (R-HSA-176963)	0.871	12
UniProt:Q14691 GINS1	1	GINS1 [nucleoplasm] (R-HSA-176955)	0.846	9
UniProt:Q9BTE3 MCMBP			0.589	2
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.527	3
UniProt:P57059 SIK1	1	SIK1 [nucleoplasm] (R-HSA-5656504)	0.527	2
UniProt:Q9BRX5 GINS3	1	GINS3 [nucleoplasm] (R-HSA-5688046)	0.527	4
UniProt:P78368 CSNK1G2	2	CSNK1G2 [plasma membrane] (R-HSA-205718) CSNK1G2 [cytosol] (R-HSA-429696)	0.527	2
UniProt:P16104 H2AX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	2
UniProt:O96017 CHEK2	3	p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784) CHEK2 [nucleoplasm] (R-HSA-113824) p-T68-CHEK2 [nucleoplasm] (R-HSA-113825)	0.499	2

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