Reactome | PKA phosphorylates DARPP-32 on Thr34

PKA phosphorylates DARPP-32 on Thr34

Stable Identifier

R-HSA-177275

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        DARPP-32 events (Homo sapiens)
        
        PKA phosphorylates DARPP-32 on Thr34 (Homo sapiens)

General

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DARPP-32 is phosphorylated by cAMP-dependent protein kinase (PKA) on a single threonine residue, Thr34, resulting in its conversion into a potent inhibitor of protein phosphatase-1.

Literature References

PubMed ID	Title	Journal	Year
6501302	DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated neuronal phosphoprotein. I. Amino acid sequence around the phosphorylated threonine Hemmings HC, Jr, Williams, KR, Konigsberg, WH, Greengard, P	J Biol Chem	1984
6296685	A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. Aswad, DW, Walaas, SI, Greengard, P	Nature	1983