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NEK2 [cytosol]
Stable Identifier
R-HSA-177329
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Nek2A
Locations in the PathwayBrowser for interactor UniProt:Q13042%20CDC16
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
APC-Cdc20 mediated degradation of Nek2A (Homo sapiens)
Association of Nek2A with MCC:APC/C (Homo sapiens)
NEK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51955 NEK2
Gene Names
NEK2, NEK2A, NLK1
Chain
chain:1-445
Reference Genes
BioGPS Gene:4751 NEK2
COSMIC (genes):NEK2 NEK2
CTD Gene:4751 NEK2
dbSNP Gene:4751 NEK2
ENSEMBL:ENSG00000117650 NEK2
ENSEMBL_homo_sapiens_GENE:ENSG00000117650.13 NEK2
HGNC:7745 NEK2
KEGG Gene (Homo sapiens):4751 NEK2
Monarch:4751 NEK2
NCBI Gene:4751 NEK2
OMIM:604043 NEK2
UCSC:P51955 NEK2
Reference Transcript
RefSeq:NM_001204183.1 NEK2
RefSeq:XM_005273147.1 NEK2
RefSeq:NM_001204182.1 NEK2
RefSeq:NM_002497.3 NEK2
Other Identifiers
11722251_a_at
11722252_x_at
11722253_a_at
11749813_a_at
11749814_s_at
11753780_x_at
11761821_at
16698984
204641_PM_at
204641_at
211080_PM_s_at
211080_s_at
2454445
2454446
2454449
2454450
2454451
2454452
2454453
2454455
2454457
2454458
2454460
2454461
2454462
2454463
2576331
2576335
3527042
3527047
3527051
3527052
366_s_at
3935709
3935713
4751
7924096
A_23_P35219
A_24_P319613
GE62449
GO:0000070
GO:0000166
GO:0000228
GO:0000278
GO:0000775
GO:0000776
GO:0000794
GO:0000922
GO:0001824
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005874
GO:0006468
GO:0007010
GO:0007049
GO:0007059
GO:0007088
GO:0016301
GO:0016310
GO:0016740
GO:0019903
GO:0022414
GO:0030496
GO:0032200
GO:0032212
GO:0032991
GO:0036211
GO:0043226
GO:0046602
GO:0046777
GO:0046872
GO:0048856
GO:0051225
GO:0051299
GO:0051301
GO:0051321
GO:0051973
GO:0051988
GO:0090307
GO:0106310
GO:0140014
GO:0140096
GO:1903126
GO:1904355
HMNXSV003043007
HMNXSV003054140
ILMN_1653822
ILMN_2051373
PH_hs_0031875
TC01003798.hg
TC01006091.hg
Z29066_s_at
g405728_3p_s_at
g4505372_3p_at
Participates
as a component of
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
Nlp-depleted centrosome [cytosol] (Homo sapiens)
centrosome containing phosphorylated Nlp [cytosol] (Homo sapiens)
cNAP-1 depleted centrosome [cytosol] (Homo sapiens)
Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
as an input of
Association of Nek2A with MCC:APC/C (Homo sapiens)
Inferred To
NEK2 [cytosol]
(Bos taurus)
NEK2 [cytosol]
(Canis familiaris)
NEK2 [cytosol]
(Dictyostelium discoideum)
NEK2 [cytosol]
(Gallus gallus)
NEK2 [cytosol]
(Mus musculus)
NEK2 [cytosol]
(Saccharomyces cerevisiae)
NEK2 [cytosol]
(Schizosaccharomyces pombe)
Ghost homologue of NEK2 [cytosol]
(Sus scrofa)
Ghost homologue of NEK2 [cytosol]
(Xenopus tropicalis)
Nek2 [cytosol]
(Drosophila melanogaster)
Nek2l1 [cytosol]
(Rattus norvegicus)
zgc:55602 [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_001191111.1
,
XP_005273204.1
,
NP_002488.1
,
NP_001191112.1
ZINC - World Drugs
NEK2_HUMAN
Guide to Pharmacology - Targets
2117
OpenTargets
ENSG00000117650
ZINC - FDA approved
NEK2_HUMAN
ZINC - Substances
NEK2_HUMAN
ZINC - Biogenic
NEK2_HUMAN
ZINC target
P51955
PRO
P51955
PDB
5M55
,
4A4X
,
2XKF
,
6SGI
,
2XK3
,
6SGH
,
5M53
,
6SK9
,
6TM5
,
6SGD
,
2XKC
,
2XNP
,
5M51
,
2XNN
,
2XKE
,
2XKD
,
2XNO
,
2XK8
,
2W5B
,
4AFE
,
2W5H
,
2XNM
,
2JAV
,
2XK4
,
2XK7
,
2W5A
,
2WQO
,
5M57
,
2XK6
,
6SGK
ZINC - Investigational
NEK2_HUMAN
ZINC - Metabolites
NEK2_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000117650-NEK2
GeneCards
P51955
Ensembl
ENSP00000355966
,
ENST00000366998
,
ENST00000366999
,
ENSP00000355965
,
ENSG00000117650
Pharos - Targets
P51955
Orphanet
22421
ZINC - Predictions - Purchasable
NEK2_HUMAN
HMDB Protein
HMDBP01340
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5T7B8 KIF24
1
KIF24 [cytosol]
(R-HSA-5626651)
0.619
7
UniProt:Q8NG66 NEK11
0.619
5
UniProt:P36873-1 PPP1CC
0.592
2
UniProt:Q8R349
2
Cdc16 [nucleoplasm]
(R-MMU-174049)
Cdc16 [cytosol]
(R-MMU-174156)
0.564
3
UniProt:Q8BGZ4
2
Cdc23 [nucleoplasm]
(R-MMU-174228)
Cdc23 [cytosol]
(R-MMU-174137)
0.564
4
UniProt:Q99JP4
2
Cdc26 [nucleoplasm]
(R-MMU-174216)
Cdc26 [cytosol]
(R-MMU-174052)
0.564
3
UniProt:Q13042 CDC16
2
CDC16 [nucleoplasm]
(R-HSA-174049)
CDC16 [cytosol]
(R-HSA-174156)
0.527
2
UniProt:Q6GQ04 Q6GQ04
0.524
2
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.499
2
UniProt:Q9UJX5 ANAPC4
2
ANAPC4 [cytosol]
(R-HSA-174168)
ANAPC4 [nucleoplasm]
(R-HSA-174115)
0.499
6
UniProt:Q83D60 Q83D60
0.488
2
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