Reactome | DNM1 [plasma membrane]

DNM1 [plasma membrane]

Stable Identifier

R-HSA-177488

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Dynamin-1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q05193 DNM1

Gene Names

DNM1, DNM

Chain

chain:1-864

Reference Genes

BioGPS Gene:1759 DNM1

COSMIC (genes):DNM1 DNM1

CTD Gene:1759 DNM1

dbSNP Gene:1759 DNM1

ENSEMBL:ENSG00000106976 DNM1

HGNC:2972 DNM1

KEGG:hsa:1759 DNM1

Monarch:1759 DNM1

NCBI Gene:1759 DNM1

OMIM:602377 DNM1

UCSC:Q05193 DNM1

Reference Transcript

Other Identifiers

11720616_a_at

11754476_x_at

11761584_x_at

17089549

1759

215116_PM_s_at

215116_s_at

3190243

3190244

3190247

3190248

3190249

3190250

3190251

3190252

3190253

3190254

3190255

3190256

3190257

3190258

3190259

3190260

3190262

3190268

3190269

3190270

3190271

3190272

3190273

3190274

3190275

3190276

3190279

3190280

3190281

3190282

3190283

3190284

3190286

3190287

3190288

3190289

3190290

3190291

3190292

3190293

3190294

3190295

3190296

3190297

3190298

3190302

3190304

32138_at

3603087

3605040

3633329

3633618

8158183

A_23_P135273

A_33_P3288209

A_33_P3329419

GE57587

GE83830

GO:0001917

GO:0003723

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005546

GO:0005547

GO:0005737

GO:0005874

GO:0005886

GO:0005905

GO:0006897

GO:0006898

GO:0007032

GO:0008017

GO:0008092

GO:0008289

GO:0016185

GO:0016192

GO:0016787

GO:0019003

GO:0019901

GO:0030117

GO:0030139

GO:0031410

GO:0031623

GO:0042583

GO:0042802

GO:0042803

GO:0042995

GO:0043226

GO:0045202

GO:0048488

GO:0050804

GO:0051260

GO:0051289

GO:0061024

GO:0065003

GO:0070062

GO:0097494

GO:0098684

GO:0098793

GO:0098835

GO:0098978

GO:0099049

GO:0099050

HMNXSV003019337

HMNXSV003035649

HMNXSV003055054

Hs.166161.2.S1_3p_a_at

ILMN_1805200

L07807_s_at

PH_hs_0040391

TC09000679.hg

TC09000680.hg

TC15000502.hg

Participates

as a component of

EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin [plasma membrane] (Homo sapiens)

as an input of

Clathrin internalises EPH:EFN complexes (Homo sapiens)

as a candidate of

Other forms of this molecule

DNM1 [lysosomal membrane]

DNM1 [cytosol]

Inferred To

DNM1 [plasma membrane] (Bos taurus)

DNM1 [plasma membrane] (Caenorhabditis elegans)

DNM1 [plasma membrane] (Canis familiaris)

DNM1 [plasma membrane] (Drosophila melanogaster)

DNM1 [plasma membrane] (Gallus gallus)

DNM1 [plasma membrane] (Mus musculus)

DNM1 [plasma membrane] (Rattus norvegicus)

DNM1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

XP_005251826.1, NP_001275666.1, XP_016869860.1, NP_001005336.1, NP_001275668.1, NP_001275667.1, NP_004399.2, XP_005251825.1

ZINC - World Drugs

DYN1_HUMAN

OpenTargets

ENSG00000106976

ENSEMBL

ENSP00000420045, ENST00000393594, ENST00000475805, ENST00000486160, ENSP00000345680, ENST00000627543, ENSP00000377219, ENSP00000419225, ENST00000341179, ENST00000372923, ENSP00000362014, ENSP00000487310

ZINC - Substances

DYN1_HUMAN

ZINC target

Q05193

PRO

Q05193

GlyGen

Q05193

PDB

7AX3, 8TYM, 2DYN, 3ZYC, 2X2E, 6DLV, 4UUD, 6S9A, 1DYN, 5D3Q, 2X2F, 8T0K, 3SNH, 8SZ7, 8TYN, 8SZ8, 4UUK, 6DLU, 8SXZ, 8SZ4, 8T0R, 3ZYS

HPA

ENSG00000106976-DNM1

Pharos - Targets

Q05193

ZINC - Predictions - Purchasable

DYN1_HUMAN

Orphanet

DNM1

HMDB Protein

HMDBP08363

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q05193 DNM1	3	DNM1 [plasma membrane] (R-HSA-177488) DNM1 [lysosomal membrane] (R-HSA-196150) DNM1 [cytosol] (R-HSA-2213182)	0.931	13
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.87	8
UniProt:Q9Y5X1 SNX9	3	SNX9 [cytosol] (R-HSA-8867737) SNX9 [Golgi membrane] (R-HSA-432988) SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990)	0.825	6
UniProt:P49418 AMPH	1	AMPH [cytosol] (R-HSA-8867728)	0.766	6
UniProt:P50570 DNM2	5	DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [plasma membrane] (R-HSA-2984201)	0.659	5
UniProt:Q8WV41 SNX33			0.641	4
UniProt:Q96JI7 SPTCS			0.635	3
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.623	3
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.609	2
UniProt:Q96RU3 FNBP1	1	FNBP1 [cytosol] (R-HSA-8862261)	0.576	5
ChEBI:51987 GDP-TETRAFLUOROALUMINATE			0.558	2
UniProt:P19804	5	NME2P1 [cytosol] (R-RNO-6806876) NME2 [cytosol] (R-RNO-60024) NME2 [ficolin-1-rich granule lumen] (R-RNO-6803324) NME2 [extracellular region] (R-RNO-6806464) NME2 [secretory granule lumen] (R-RNO-6803277)	0.544	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.543	4
UniProt:Q9UQ16 DNM3	2	DNM3 [cytosol] (R-HSA-2213188) DNM3 [plasma membrane] (R-HSA-443610)	0.527	2
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.524	2
UniProt:Q8IVI9 NOSTRIN	2	NOSTRIN [endocytic vesicle membrane] (R-HSA-535014) NOSTRIN [plasma membrane] (R-HSA-202134)	0.524	3
UniProt:Q9QYW3 PHOCN			0.489	2