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SH3GL2 [plasma membrane]
Stable Identifier
R-HSA-177495
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Endophilin
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Recycling pathway of L1 (Homo sapiens)
Formation of clathrin coated vesicle (Homo sapiens)
L1:AP-2 Clathrin complex [clathrin-coated endocytic vesicle] (Homo sapiens)
SH3GL2 [plasma membrane] (Homo sapiens)
SH3GL2 [plasma membrane] (Homo sapiens)
Phosphorylation of L1 by ERK (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
SH3GL2 [plasma membrane] (Homo sapiens)
pL1 (S1204, 1248):ERK2:clathrin-dynamin complex [endosome] (Homo sapiens)
SH3GL2 [plasma membrane] (Homo sapiens)
Phosphorylation of L1 by p90rsk (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
SH3GL2 [plasma membrane] (Homo sapiens)
pL1 (S1152):p90rsk:clathrin-dynamin complex [endosome] (Homo sapiens)
SH3GL2 [plasma membrane] (Homo sapiens)
Reinsertion of L1 into the plasma membrane (Homo sapiens)
AP2 clathrin:L1:KIF4:microtubule [cytosol] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
SH3GL2 [plasma membrane] (Homo sapiens)
SH3GL2 [plasma membrane] (Homo sapiens)
Transport of L1 from C-domain to P-domain (Homo sapiens)
AP2 clathrin:L1:KIF4:microtubule [cytosol] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
SH3GL2 [plasma membrane] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
SH3GL2 [plasma membrane] (Homo sapiens)
Transport of L1 into endosomes (Homo sapiens)
L1:AP-2 Clathrin complex [clathrin-coated endocytic vesicle] (Homo sapiens)
SH3GL2 [plasma membrane] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
SH3GL2 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)
SH3GL2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Retrograde neurotrophin signalling (Homo sapiens)
Axonal transport of NGF:Trk complexes (Homo sapiens)
Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Homo sapiens)
SH3GL2 [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex:Clathrin-coated vesicle:dynein:dynactin complex [plasma membrane] (Homo sapiens)
SH3GL2 [plasma membrane] (Homo sapiens)
Endocytosis (internalization) of clathrin-coated vesicle (Homo sapiens)
Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Homo sapiens)
SH3GL2 [plasma membrane] (Homo sapiens)
SH3GL2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99962 SH3GL2
Gene Names
SH3GL2, CNSA2, SH3D2A
Chain
chain:1-352
Reference Genes
BioGPS Gene:6456 SH3GL2
COSMIC (genes):SH3GL2 SH3GL2
CTD Gene:6456 SH3GL2
dbSNP Gene:6456 SH3GL2
ENSEMBL:ENSG00000107295 SH3GL2
HGNC:10831 SH3GL2
KEGG:hsa:6456 SH3GL2
Monarch:6456 SH3GL2
NCBI Gene:6456 SH3GL2
OMIM:604465 SH3GL2
UCSC:Q99962 SH3GL2
Reference Transcript
RefSeq:NM_003026.3 SH3GL2
Other Identifiers
11730182_a_at
11730183_s_at
17083776
205751_PM_at
205751_at
3163827
3163828
3163829
3163830
3163831
3163845
3163860
3163861
3163863
3163866
3163868
3163869
3163870
3163871
3163872
3163873
3163874
3163875
40378_at
6456
8154476
A_14_P101372
A_14_P107438
A_23_P169351
GE54291
GO:0000139
GO:0001933
GO:0003013
GO:0005515
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005886
GO:0006897
GO:0007165
GO:0007417
GO:0008289
GO:0010629
GO:0016020
GO:0016191
GO:0016192
GO:0030669
GO:0031175
GO:0031410
GO:0042802
GO:0042995
GO:0043226
GO:0045202
GO:0048471
GO:0048856
GO:0097484
GO:0098793
GO:0098978
GO:1905604
GO:1990416
HMNXSV003007293
ILMN_1661491
TC09000085.hg
X99657_at
g4506930_3p_at
Participates
as an input of
Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)
Formation of clathrin coated vesicle (Homo sapiens)
Endocytosis (internalization) of clathrin-coated vesicle (Homo sapiens)
as a component of
pL1 (S1204, 1248):ERK2:clathrin-dynamin complex [endosome] (Homo sapiens)
pL1 (S1152):p90rsk:clathrin-dynamin complex [endosome] (Homo sapiens)
L1:AP-2 Clathrin complex [clathrin-coated endocytic vesicle] (Homo sapiens)
L1:AP-2 Clathrin complex [endosome] (Homo sapiens)
Activated TrkA receptor complex:Clathrin-coated vesicle:dynein:dynactin complex [plasma membrane] (Homo sapiens)
Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin [plasma membrane] (Homo sapiens)
as an output of
Reinsertion of L1 into the plasma membrane (Homo sapiens)
Other forms of this molecule
SH3GL2 [cytosol]
SH3GL2 [clathrin-coated endocytic vesicle membrane]
SH3GL2 [Golgi membrane]
Inferred To
Ghost homologue of SH3GL2 [plasma membrane]
(Saccharomyces cerevisiae)
Homologues of SH3GL2 [plasma membrane]
(Dictyostelium discoideum)
SH3GL2 [plasma membrane]
(Bos taurus)
SH3GL2 [plasma membrane]
(Canis familiaris)
SH3GL2 [plasma membrane]
(Dictyostelium discoideum)
SH3GL2 [plasma membrane]
(Gallus gallus)
SH3GL2 [plasma membrane]
(Schizosaccharomyces pombe)
SH3GL2 [plasma membrane]
(Sus scrofa)
sh3gl2 [plasma membrane]
(Xenopus tropicalis)
Sh3gl2 [plasma membrane]
(Mus musculus)
Sh3gl2 [plasma membrane]
(Rattus norvegicus)
EndoA [plasma membrane]
(Drosophila melanogaster)
unc-57 [plasma membrane]
(Caenorhabditis elegans)
sh3gl2a [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_003017.1
OpenTargets
ENSG00000107295
ENSEMBL
ENST00000380607
,
ENSP00000369981
HPA
ENSG00000107295-SH3GL2
PRO
Q99962
Pharos - Targets
Q99962
PDB
2DBM
,
2D4C
,
1X04
,
1X03
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99961 SH3GL1
1
SH3GL1 [cytosol]
(R-HSA-8867732)
0.804
7
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.788
5
UniProt:Q99700 ATX2
0.779
9
UniProt:Q99962 SH3GL2
4
SH3GL2 [plasma membrane]
(R-HSA-177495)
SH3GL2 [cytosol]
(R-HSA-182958)
SH3GL2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130629)
SH3GL2 [Golgi membrane]
(R-HSA-351189)
0.744
4
UniProt:P50570 DNM2
5
DNM2 [Golgi membrane]
(R-HSA-2980842)
DNM2 [endocytic vesicle membrane]
(R-HSA-2029000)
DNM2 [cytosol]
(R-HSA-2213180)
DNM2 [lysosomal membrane]
(R-HSA-2980840)
DNM2 [plasma membrane]
(R-HSA-2984201)
0.722
4
UniProt:Q99963 SH3GL3
1
SH3GL3 [cytosol]
(R-HSA-8867734)
0.721
7
UniProt:Q70E73 RAPH1
0.72
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.681
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.623
4
UniProt:Q924I2 M4K3
0.611
3
UniProt:Q6ICL3 TNG2
0.589
2
UniProt:Q62910
1
Synj1 [cytosol]
(R-RNO-1604634)
0.573
2
UniProt:O43426 SYNJ1
1
SYNJ1 [cytosol]
(R-HSA-1604634)
0.558
2
UniProt:Q8IUX8 EGFL6
0.553
2
UniProt:P20160 AZU1
2
AZU1 [extracellular region]
(R-HSA-6806193)
AZU1 [azurophil granule lumen]
(R-HSA-6798767)
0.527
2
UniProt:Q96J02 ITCH
2
Ub-C871-ITCH [cytosol]
(R-HSA-8864515)
ITCH [cytosol]
(R-HSA-975995)
0.526
3
UniProt:Q13444 ADAM15
1
ADAM15 [plasma membrane]
(R-HSA-708329)
0.508
2
UniProt:Q13443 ADAM9
1
ADAM9 [plasma membrane]
(R-HSA-708336)
0.508
2
UniProt:P50402 EMD
4
EMD [nuclear envelope]
(R-HSA-201573)
EMD [cytosol]
(R-HSA-9613988)
EMD [endoplasmic reticulum membrane]
(R-HSA-9613998)
EMD [endosome membrane]
(R-HSA-9715092)
0.508
2
UniProt:Q9H3S7 PTPN23
1
PTPN23 [nucleoplasm]
(R-HSA-9008924)
0.508
2
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL [cytosol]
(R-HSA-112199)
p-Y371-CBL [cytosol]
(R-HSA-182940)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
0.499
2
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