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p-S176,S180-CHUK [cytosol]
Stable Identifier
R-HSA-177667
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S176,S180-IKKA,
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of Immune System (Homo sapiens)
Diseases associated with the TLR signaling cascade (Homo sapiens)
IkBA variant leads to EDA-ID (Homo sapiens)
NFKBIA variant is not phosphorylated within IkBA:NF-kappaB (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Infectious disease (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
NIK-->noncanonical NF-kB signaling (Homo sapiens)
Active NIK phosphorylates IKKA dimer (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Homo sapiens)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
p100:RELB binds active NIK:p-IKKA dimer (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
Active NIK phosphorylates IKKA dimer (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Homo sapiens)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
p100:RELB binds active NIK:p-IKKA dimer (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer:p100:RELB [cytosol] (Homo sapiens)
Active NIK:p-S176,180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
RIP-mediated NFkB activation via ZBP1 (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
RIP1 facilitates IKK complex phosphorylation (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
Activation of IKK by MEKK1 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
NOD1/2 Signaling Pathway (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
CYLD is phosphorylated by IKK (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S176,S180-CHUK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15111 CHUK
Gene Names
CHUK, IKKA, TCF16
Chain
chain:1-745
Reference Genes
BioGPS Gene:1147 CHUK
COSMIC (genes):CHUK CHUK
CTD Gene:1147 CHUK
dbSNP Gene:1147 CHUK
ENSEMBL:ENSG00000213341 CHUK
HGNC:1974 CHUK
KEGG Gene (Homo sapiens):1147 CHUK
Monarch:1147 CHUK
NCBI Gene:1147 CHUK
OMIM:600664 CHUK
UCSC:O15111 CHUK
Reference Transcript
RefSeq:NM_001278.4 CHUK
Other Identifiers
0006110142
1147
11754797_a_at
16717469
209666_s_at
3303298
3303299
3303301
3303302
3303304
3303309
3303310
3303312
3303314
3303315
3303320
3303321
3303322
3303324
3303325
3303326
3303327
3303328
3303329
3303330
3303331
3303332
3303333
3303334
3303335
3303336
3303337
3303338
33770_at
7935707
A_23_P46748
A_33_P3258141
GE62511
GE81000
GO:0000166
GO:0002223
GO:0002376
GO:0002479
GO:0002756
GO:0003009
GO:0003674
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006464
GO:0006468
GO:0006950
GO:0006954
GO:0006955
GO:0007165
GO:0007249
GO:0007252
GO:0007266
GO:0008150
GO:0008384
GO:0008385
GO:0009058
GO:0009615
GO:0009636
GO:0009653
GO:0009898
GO:0010033
GO:0010034
GO:0010803
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0030154
GO:0032088
GO:0032496
GO:0032727
GO:0032991
GO:0033194
GO:0033209
GO:0034614
GO:0034641
GO:0035631
GO:0035666
GO:0038061
GO:0038095
GO:0042493
GO:0042803
GO:0043123
GO:0043167
GO:0043200
GO:0043226
GO:0043231
GO:0044877
GO:0045087
GO:0045893
GO:0045944
GO:0046982
GO:0048856
GO:0050852
GO:0051092
GO:0051146
GO:0051403
GO:0061847
GO:0070498
GO:0071276
GO:0071356
GO:0097110
GO:0098586
GO:1990459
HMNXSV003015828
ILMN_1677041
PH_hs_0011697
TC10002931.hg
g4185272_3p_s_at
Participates
as a component of
p-S176,S180-IKKA dimer [cytosol] (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Other forms of this molecule
CHUK [cytosol]
p-T23-CHUK [cytosol]
Inferred To
phospho-chuk [cytosol]
(Danio rerio)
phospho-chuk [cytosol]
(Xenopus tropicalis)
phospho-IKKbeta [cytosol]
(Drosophila melanogaster)
phospho-CHUK [cytosol]
(Canis familiaris)
phospho-CHUK [cytosol]
(Sus scrofa)
Ghost homologue of p-S176,S180-CHUK [cytosol]
(Bos taurus)
phospho-Chuk [cytosol]
(Mus musculus)
phospho-Chuk [cytosol]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-serine at 176
Coordinate
176
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 180
Coordinate
180
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001269.3
ZINC - World Drugs
IKKA_HUMAN
Guide to Pharmacology - Targets
1989
OpenTargets
ENSG00000213341
ZINC - FDA approved
IKKA_HUMAN
ZINC - Substances
IKKA_HUMAN
ZINC - Biogenic
IKKA_HUMAN
ZINC target
O15111
PRO
O15111
GlyGen
O15111
PDB
3BRT
,
5TQX
,
5EBZ
,
5TQW
,
5TQY
ZINC - Investigational
IKKA_HUMAN
IntEnz
2.7.11.10
HPA
ENSG00000213341-CHUK
GeneCards
O15111
Ensembl
ENSG00000213341
,
ENSP00000359424
,
ENST00000370397
Pharos - Targets
O15111
Orphanet
24278
ZINC - Predictions - Purchasable
IKKA_HUMAN
HMDB Protein
HMDBP02038
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y6K9 IKBKG
12
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wro*447 [cytosol]
(R-HSA-5262978)
K63polyUb-NEMO [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.97
28
UniProt:P25963 NFKBIA
10
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol]
(R-HSA-5607659)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
0.95
15
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB [cytosol]
(R-HSA-168114)
0.949
18
UniProt:Q99558 MAP3K14
5
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
0.941
13
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.802
5
UniProt:P19838 NFKB1
8
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.713
3
UniProt:O43318 MAP3K7
10
PolyUb-MAP3K7 [cytosol]
(R-HSA-6782968)
MAP3K7 [plasma membrane]
(R-HSA-9012677)
K63polyUb-34,158-TAK1 [cytosol]
(R-HSA-5607643)
K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol]
(R-HSA-5607649)
p-MAP3K7 [cytosol]
(R-HSA-168163)
p-T187-MAP3K7 [cytosol]
(R-HSA-206014)
MAP3K7 [endosome membrane]
(R-HSA-450315)
p-T184,T187-MAP3K7 [endosome membrane]
(R-HSA-450332)
MAP3K7 [cytosol]
(R-HSA-168156)
p-T184,T187-MAP3K7 [cytosol]
(R-HSA-202527)
0.65
3
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.641
3
UniProt:P24772 B14
0.623
3
UniProt:O15111 CHUK
3
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
0.609
2
UniProt:Q7Z406 MYH14
1
MYH14 [cytosol]
(R-HSA-419176)
0.564
2
UniProt:P07900 HSP90AA1
8
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.564
3
UniProt:Q04206 RELA
6
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.564
2
UniProt:Q86VP1 TAX1BP1
1
TAX1BP1 [cytosol]
(R-HSA-937346)
0.544
2
UniProt:Q99759 MAP3K3
1
MAP3K3 [cytosol]
(R-HSA-507725)
0.536
2
UniProt:Q86WI3 NLRC5
1
NLRC5 [cytosol]
(R-HSA-937324)
0.524
3
UniProt:Q5TCX8 M3K21
0.524
2
UniProt:Q15796 SMAD2
20
Ub-SMAD2 [cytosol]
(R-HSA-6782774)
p-S465,S467-SMAD2 P305L [cytosol]
(R-HSA-3315471)
p-S465,S467-SMAD2 D300A [cytosol]
(R-HSA-3315064)
p-S465,S467-SMAD2 D300N [cytosol]
(R-HSA-3315066)
p-S465,S467-SMAD2 A354T [cytosol]
(R-HSA-3315474)
p-S465,S467-SMAD2 P305Q [cytosol]
(R-HSA-3315070)
p-S465,S467-SMAD2 D300V [cytosol]
(R-HSA-3315067)
SMAD2 S464* [cytosol]
(R-HSA-3304362)
SMAD2 W422* [cytosol]
(R-HSA-9668736)
SMAD2 S308* [cytosol]
(R-HSA-9668732)
SMAD2 R427* [cytosol]
(R-HSA-9668733)
SMAD2 W448* [cytosol]
(R-HSA-9668734)
SMAD2 S464L [cytosol]
(R-HSA-3304383)
SMAD2 C463* [cytosol]
(R-HSA-9668735)
SMAD2 R321* [cytosol]
(R-HSA-9668728)
SMAD2 S296* [cytosol]
(R-HSA-9668729)
SMAD2 S306* [cytosol]
(R-HSA-9668730)
SMAD2 Q455* [cytosol]
(R-HSA-9668731)
SMAD2 E439* [cytosol]
(R-HSA-9668724)
SMAD2 L315* [cytosol]
(R-HSA-9668725)
0.524
2
UniProt:Q9ULZ3 PYCARD
4
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
0.512
5
UniProt:P71451 INLC
0.509
3
UniProt:P32121 ARRB2
2
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
0.483
3
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.463
3
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