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NFKB2(1-454) [nucleoplasm]
Stable Identifier
R-HSA-177674
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NFkB2 p52, Nuclear factor NF-kappa-B p52 subunit
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
SETD6 methylates RELA in the NFkB complex (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
NFkB Complex with MeK310-RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
Expression of NLRP3 gene (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 processing (Homo sapiens)
Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
NIK-->noncanonical NF-kB signaling (Homo sapiens)
p52:RELB translocates from cytosol to nucleus (Homo sapiens)
p52:RELB [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
CCL17 and CCL22 genes are transcribed (Homo sapiens)
p52:RELB [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
p52:RELB translocates from cytosol to nucleus (Homo sapiens)
p52:RELB [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (Homo sapiens)
NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
RIP-mediated NFkB activation via ZBP1 (Homo sapiens)
NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
Expression of NLRP3 gene (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB2(1-454) [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q00653 NFKB2
Gene Names
NFKB2, LYT10
Chain
chain:1-900, chain:1-454
Reference Genes
BioGPS Gene:4791 NFKB2
COSMIC (genes):NFKB2 NFKB2
CTD Gene:4791 NFKB2
dbSNP Gene:4791 NFKB2
ENSEMBL:ENSG00000077150 NFKB2
HGNC:7795 NFKB2
KEGG:hsa:4791 NFKB2
Monarch:4791 NFKB2
NCBI Gene:4791 NFKB2
OMIM:164012 NFKB2
UCSC:Q00653 NFKB2
Reference Transcript
RefSeq:NM_001261403.2 NFKB2
RefSeq:NM_001077494.3 NFKB2
RefSeq:NM_002502.5 NFKB2
RefSeq:NM_001322935.1 NFKB2
RefSeq:NM_001288724.1 NFKB2
RefSeq:NM_001322934.1 NFKB2
Other Identifiers
11725153_a_at
16708623
207535_3p_s_at
207535_PM_s_at
207535_s_at
209636_3p_at
209636_PM_at
209636_at
3261644
3261645
3261646
3261647
3261648
3261649
3261650
3261651
3261652
3261653
3261654
3261655
3261656
3261657
3261658
3261659
3261660
3261661
3261662
3261663
3261664
3261665
3261666
3261667
3261668
3261669
3261670
3261671
3261672
3261673
3261674
3261675
3261676
3261677
3261678
3261679
3261680
3261681
3261682
40362_at
4791
535_s_at
544_at
545_g_at
7930074
A_14_P114090
A_23_P202156
GE81163
GO:0000785
GO:0000978
GO:0000981
GO:0001228
GO:0002268
GO:0002376
GO:0002467
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0006954
GO:0007165
GO:0007249
GO:0010468
GO:0030154
GO:0030198
GO:0032496
GO:0033257
GO:0034097
GO:0038061
GO:0043226
GO:0045087
GO:0045944
GO:0048511
GO:0048536
GO:0048856
GO:0098542
GO:0140110
GO:1990837
HMNXSV003045072
ILMN_1799062
ILMN_2247868
ILMN_2390859
PH_hs_0027671
S76638_at
TC10000753.hg
U20816_s_at
g12803988_3p_at
g12803988_3p_x_at
Participates
as a component of
p52:RELB [nucleoplasm] (Homo sapiens)
as a member of
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
NFKB2(1-454) [cytosol]
p-7S-p100 [cytosol]
K48-polyUb-p-7S-p100 [cytosol]
NFKB2(1-900) [cytosol]
monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol]
Inferred To
Rel [nucleoplasm]
(Drosophila melanogaster)
Nfkb2 [nucleoplasm]
(Mus musculus)
Nfkb2 [nucleoplasm]
(Rattus norvegicus)
NFKB2 [nucleoplasm]
(Bos taurus)
NFKB2 [nucleoplasm]
(Canis familiaris)
NFKB2 [nucleoplasm]
(Sus scrofa)
nfkb2 [nucleoplasm]
(Danio rerio)
NFKB2(1-454) [nucleoplasm]
(Gallus gallus)
Cross References
RefSeq
NP_001275653.1
,
NP_001248332.1
,
NP_001070962.1
,
NP_002493.3
,
NP_001309864.1
,
NP_001309863.1
Guide to Pharmacology - Targets
3282
OpenTargets
ENSG00000077150
ENSEMBL
ENSP00000499294
,
ENSP00000358983
,
ENST00000652277
,
ENSP00000498308
,
ENST00000428099
,
ENST00000189444
,
ENST00000661543
,
ENSP00000410256
,
ENSP00000189444
,
ENST00000369966
HPA
ENSG00000077150-NFKB2
PRO
Q00653
Pharos - Targets
Q00653
GlyGen
Q00653
Orphanet
NFKB2
PDB
4OT9
,
2D96
,
1A3Q
,
7W7L
,
7CLI
,
5ZMC
,
7VUQ
,
3DO7
,
7VUP
,
8G8Q
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19838 NFKB1
8
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
0.823
10
UniProt:P25963 NFKBIA
9
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
0.744
5
UniProt:Q01201 RELB
2
RELB [nucleoplasm]
(R-HSA-5607656)
RELB [cytosol]
(R-HSA-5607652)
0.744
6
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.744
6
UniProt:Q99558 MAP3K14
5
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
0.643
4
UniProt:Q9NWT6 HIF1AN
1
HIF1AN [cytosol]
(R-HSA-1234154)
0.643
3
UniProt:P41279 MAP3K8
3
p-S400,T290-MAP3K8 [cytosol]
(R-HSA-5684259)
MAP3K8 [cytosol]
(R-HSA-389388)
p-S400-MAP3K8 [cytosol]
(R-HSA-389738)
0.564
3
UniProt:Q15653 NFKBIB
3
p-S19,S23-Ub-NFKBIB [cytosol]
(R-HSA-1168571)
p-S19,S23-NFKBIB [cytosol]
(R-HSA-177670)
NFKBIB [cytosol]
(R-HSA-168132)
0.564
4
UniProt:P09917 ALOX5
6
p-S272-ALOX5 [nuclear envelope]
(R-HSA-2318765)
ALOX5 [cytosol]
(R-HSA-429010)
ALOX5 [secretory granule lumen]
(R-HSA-6801306)
ALOX5 [extracellular region]
(R-HSA-6806468)
ALOX5 [ficolin-1-rich granule lumen]
(R-HSA-6801302)
p-S272-ALOX5 [cytosol]
(R-HSA-265276)
0.527
2
UniProt:Q9H4E7 DEF6
1
DEF6 [cytosol]
(R-HSA-9691487)
0.527
3
UniProt:Q9ULW8 PADI3
2
PADI3 [cytosol]
(R-HSA-1183173)
PADI3 [nucleoplasm]
(R-HSA-6793444)
0.527
3
UniProt:Q8NI38 IKBD
0.527
3
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