Reactome | RELA [nucleoplasm]

RELA [nucleoplasm]

Stable Identifier

R-HSA-177676

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NFkB3, Nuclear factor NF-kappa-B p65 subunit, Transcription factor p65

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Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of immune response proteins (Homo sapiens)
        
        PIAS3 SUMOylates RELA with SUMO3 (Homo sapiens)
        
        RELA:RELA:DNA [nucleoplasm] (Homo sapiens)
        
        NF-kB p65:p65 [nucleoplasm] (Homo sapiens)
        
        RELA [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q04206 RELA

Gene Names

RELA, NFKB3

Chain

chain:1-551

Reference Genes

BioGPS Gene:5970 RELA

COSMIC (genes):RELA RELA

CTD Gene:5970 RELA

dbSNP Gene:5970 RELA

ENSEMBL:ENSG00000173039 RELA

ENSEMBL:ENSG00000173039.20 RELA

HGNC:9955 RELA

KEGG Gene (Homo sapiens):5970 RELA

Monarch:5970 RELA

NCBI Gene:5970 RELA

OMIM:164014 RELA

UCSC:Q04206 RELA

Reference Transcript

Other Identifiers

1045_s_at

11718104_x_at

11745440_s_at

1271_g_at

1295_at

16740495

201783_PM_s_at

201783_s_at

209878_PM_s_at

209878_s_at

3021614

3377790

3377791

3377792

3377793

3377794

3377795

3377796

3377799

3377800

3377802

3377803

3377805

3377806

3377807

3377810

3377811

3377812

3377814

3377817

36645_at

5970

7949465

A_23_P104689

A_24_P937256

A_33_P3209433

GE61225

GO:0000122

GO:0000785

GO:0000976

GO:0000977

GO:0000978

GO:0000979

GO:0000981

GO:0001223

GO:0001227

GO:0001228

GO:0001889

GO:0001942

GO:0002357

GO:0002376

GO:0002931

GO:0003677

GO:0003682

GO:0003690

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005829

GO:0006117

GO:0006325

GO:0006351

GO:0006355

GO:0006357

GO:0006952

GO:0006954

GO:0006968

GO:0007155

GO:0007218

GO:0007249

GO:0008092

GO:0008284

GO:0009410

GO:0009612

GO:0009617

GO:0009887

GO:0010033

GO:0010035

GO:0010224

GO:0010468

GO:0010575

GO:0010628

GO:0012501

GO:0014040

GO:0014070

GO:0019221

GO:0019899

GO:0019901

GO:0023052

GO:0030154

GO:0030163

GO:0031490

GO:0031625

GO:0032495

GO:0032496

GO:0032570

GO:0032735

GO:0032755

GO:0032757

GO:0032868

GO:0032991

GO:0033209

GO:0033234

GO:0033590

GO:0034097

GO:0035525

GO:0035729

GO:0035924

GO:0035994

GO:0036211

GO:0038061

GO:0042177

GO:0042277

GO:0042301

GO:0042542

GO:0042802

GO:0042803

GO:0042805

GO:0042826

GO:0043066

GO:0043123

GO:0043200

GO:0043226

GO:0043565

GO:0043620

GO:0044877

GO:0045087

GO:0045202

GO:0045892

GO:0045893

GO:0045944

GO:0046627

GO:0048856

GO:0050727

GO:0050862

GO:0051059

GO:0051092

GO:0051591

GO:0051607

GO:0070301

GO:0070431

GO:0070498

GO:0070555

GO:0071159

GO:0071222

GO:0071223

GO:0071224

GO:0071316

GO:0071347

GO:0071354

GO:0071356

GO:0071532

GO:0098542

GO:0098978

GO:0099527

GO:0140110

GO:0140296

GO:0140297

GO:1901222

GO:1901223

GO:1901224

GO:1901522

GO:1902004

GO:1902894

GO:1902895

GO:1904385

GO:1904996

GO:2000630

GO:2001237

HMNXSV003020531

ILMN_1705266

PH_hs_0022492

PH_hs_0035578

TC11001939.hg

TC11003206.hg

TC11003207.hg

U33838_s_at

Z22951_rna1_s_at

g11496238_3p_at

g189503_3p_a_at

p33858

Participates

as a component of

Other forms of this molecule

MeK310-RELA [nucleoplasm]

polySUMO3-K37,K122,K123-RELA [nucleoplasm]

p-S276,5xAcK-RELA [nucleoplasm]

p-S276-RELA [nucleoplasm]

RELA [cytosol]

Inferred To

Rel [nucleoplasm] (Drosophila melanogaster)

Dif [nucleoplasm] (Drosophila melanogaster)

c-rel [nucleoplasm] (Danio rerio)

rela [nucleoplasm] (Xenopus tropicalis)

RELA [nucleoplasm] (Bos taurus)

RELA [nucleoplasm] (Canis familiaris)

RELA [nucleoplasm] (Gallus gallus)

RELA [nucleoplasm] (Sus scrofa)

Homologues of RELA [nucleoplasm] (Drosophila melanogaster)

Rela [nucleoplasm] (Mus musculus)

Rela [nucleoplasm] (Rattus norvegicus)

dl [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001138610.1, NP_001230913.1, NP_068810.3

OpenTargets

ENSG00000173039

ZINC - Substances

TF65_HUMAN

ZINC - Biogenic

TF65_HUMAN

ZINC target

Q04206

PRO

Q04206

PDB

7BIW, 7NMH, 7BJW, 7NK5, 6NV2, 6YP3, 7O57, 6YPY, 7NZG, 6YP2, 6YQ2, 6QHM, 7NQP, 7NWS, 5U4K, 7NZ6, 6YP8, 7LF4, 7NY4, 7BIY, 7LEU, 7NK3, 7O6J, 7NJB, 4KV1, 7NV4, 7BKH, 7NM9, 7O6K, 7BIQ, 7O6G, 6YOX, 7BJL, 7NZK, 3GUT, 7O3Q, 7O34, 7NYF, 7NYG, 7O6I, 4KV4, 7NLE, 5URN, 2LSP, 7NVI, 7LET, 7O3P, 7O6F, 7NYE, 6YOY, 7O6M, 7BI3, 7O3F, 7NXY, 7O6O, 7NLA, 7O5G, 7O5X, 1NFI, 7O5F, 7BJF, 6YPL, 7O5S, 7O3S, 7NXT, 7NSV, 3QXY, 7NZV, 7BJB, 7O5D, 7NXW, 7O5C, 7O3A, 7O5U, 7O5P, 2O61, 7NJ9, 7O59, 6QHL, 7O5O, 3RC0, 7NM1, 7O5A, 7NR7, 7NM3, 7NXS, 6YOW, 7O3R

ZINC - Investigational

TF65_HUMAN

ZINC - Metabolites

TF65_HUMAN

HPA

ENSG00000173039-RELA

GeneCards

Q04206

Ensembl

ENST00000308639, ENSP00000384273, ENSP00000311508, ENST00000406246, ENSG00000173039

Pharos - Targets

Q04206

Orphanet

22677

ZINC - Predictions - Purchasable

TF65_HUMAN

Interactors (97)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25963 NFKBIA	11	PolyUb-NFKBIA [cytosol] (R-HSA-6782960) NFKBIA M37K [cytosol] (R-HSA-5228805) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol] (R-HSA-5607659) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-9711050) NFKBIA S32I [cytosol] (R-HSA-5228846)	0.975	25
UniProt:P19838 NFKB1	8	NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.916	14
UniProt:NFKBIA ENSG00000100906			0.905	8
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.832	9
UniProt:O60885 BRD4	1	BRD4 [nucleoplasm] (R-HSA-9680425)	0.811	8
UniProt:P23396 RPS3	2	RPS3 [nucleoplasm] (R-HSA-6798714) RPS3 [cytosol] (R-HSA-72369)	0.797	8
UniProt:P19838-PRO_0000030311 NFKB1			0.793	7
IntAct:EBI-1566585 IL8			0.788	9
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.77	6
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.757	6
UniProt:Q15653 NFKBIB	3	p-S19,S23-Ub-NFKBIB [cytosol] (R-HSA-1168571) p-S19,S23-NFKBIB [cytosol] (R-HSA-177670) NFKBIB [cytosol] (R-HSA-168132)	0.75	6
UniProt:Q8WTS6 SETD7	1	SETD7 [nucleoplasm] (R-HSA-1183221)	0.737	12
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.729	5
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.693	5
UniProt:Q8N668 COMMD1	2	COMMD1 [nucleoplasm] (R-HSA-8955094) COMMD1 [cytosol] (R-HSA-8955110)	0.693	7
UniProt:P14598 NCF1	4	NCF1 [cytosol] (R-HSA-1222296) p-6S-NCF1 [phagolysosome] (R-HSA-1996220) p-S345-NCF1 [cytosol] (R-HSA-9626824) p-6S-NCF1 [cytosol] (R-HSA-9626854)	0.682	8
UniProt:O14920 IKBKB	3	IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506)	0.676	3
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.658	4
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.656	6
IntAct:EBI-2213855 BIRC3			0.643	3
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.639	5
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.625	4
UniProt:Q16236 NFE2L2	13	p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-NFE2L2 [cytosol] (R-HSA-9758077) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.625	5
UniProt:P18847-3 ATF3			0.623	5
UniProt:O00255-2 MEN1			0.602	4
UniProt:Q8N6T7 SIRT6	1	SIRT6 [nucleoplasm] (R-HSA-5685963)	0.602	4
UniProt:Q9ESU6 BRD4			0.602	6
IntAct:EBI-10826665 NKILA			0.599	6
UniProt:Q9BQ69 MACD1			0.599	7
UniProt:Q53EL6 PDCD4	1	PDCD4 [cytosol] (R-HSA-5432887)	0.599	6
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.592	4
UniProt:P46695 IER3	1	IER3 [cytosol] (R-HSA-6811515)	0.591	6
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) PPP2CA [cytosol] (R-HSA-165971)	0.591	6
UniProt:Q8X834 Q8X834			0.59	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.589	3
UniProt:P17612 PRKACA	3	PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.581	3
UniProt:Q99612 KLF6			0.576	6
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.573	3
UniProt:O15111 CHUK	3	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615)	0.564	2
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.558	4
UniProt:Q13625-2 TP53BP2			0.557	6
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.556	3
UniProt:P55212 CASP6	5	CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:O41974 O41974			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:P06307 CCK	1	CCK [extracellular region] (R-HSA-388539)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.556	5
UniProt:P68400 CSNK2A1	2	CSNK2A1 [nucleoplasm] (R-HSA-6805057) CSNK2A1 [cytosol] (R-HSA-201713)	0.544	2
UniProt:P22736-1 NR4A1			0.544	3
UniProt:Q8VIM5-1 MYOCD			0.544	2
UniProt:Q8IXJ6 SIRT2	1	SIRT2 [cytosol] (R-HSA-2161118)	0.544	2
UniProt:P25791 LMO2	1	LMO2 [nucleoplasm] (R-HSA-8956513)	0.543	3
UniProt:O75582 RPS6KA5	3	RPS6KA5 [cytosol] (R-HSA-772525) RPS6KA5 [nucleoplasm] (R-HSA-198657) p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm] (R-HSA-198683)	0.536	2
IntAct:EBI-6726290 ICAM1			0.527	3
UniProt:CCL2 ENSG00000108691			0.527	3
UniProt:TNF ENSG00000204490			0.527	3
IntAct:EBI-9873017 BIRC2			0.527	2
UniProt:IL2 ENSG00000109471			0.527	2
IntAct:EBI-1550784 CDKN1A			0.527	2
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.527	2
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.524	2
IntAct:EBI-10052614 ICAM1			0.524	3
UniProt:P0C774 V			0.524	3
UniProt:P10226 PAP			0.524	6
UniProt:Q96JB5 CK5P3			0.524	4
UniProt:Q13568 IRF5	1	IRF5 [cytosol] (R-HSA-1015676)	0.524	4
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.524	3
UniProt:P69976 SCTL			0.508	2
UniProt:P31491 YERA			0.508	2
UniProt:A0A380PFV1 A0A380PFV1			0.508	2
UniProt:P53779 MAPK10	3	MAPK10 [cytosol] (R-HSA-450352) p-T221,Y223-MAPK10 [cytosol] (R-HSA-450214) p-T221,Y223-MAPK10 [nucleoplasm] (R-HSA-450311)	0.508	2
UniProt:A0A384KL23 A0A384KL23			0.508	2
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.499	2
IntAct:EBI-958860 BCL10			0.499	2
UniProt:Q9H9B1 EHMT1	1	EHMT1 [nucleoplasm] (R-HSA-1183226)	0.499	3
UniProt:B3CRR2 B3CRR2			0.499	3
IntAct:EBI-10021116 CCL5-DERIVED			0.499	3
IntAct:EBI-10021813 CCL5			0.499	4
UniProt:O15294 OGT	2	OGT [nucleoplasm] (R-HSA-3321845) OGT [cytosol] (R-HSA-9687814)	0.499	2
IntAct:EBI-10021565 CCL5-DERIVED			0.499	2
UniProt:B3CTB0 B3CTB0			0.499	2
UniProt:O00221 NFKBIE	3	p-S157,S161-Ub-NFKBIE [cytosol] (R-HSA-1168563) NFKBIE [cytosol] (R-HSA-1168580) p-S157,S161-NFKBIE [cytosol] (R-HSA-1168561)	0.488	2
UniProt:Q01201 RELB	2	RELB [nucleoplasm] (R-HSA-5607656) RELB [cytosol] (R-HSA-5607652)	0.483	2
UniProt:Q13148 TADBP			0.463	3
UniProt:P78545 ELF3	2	ELF3 [nucleoplasm] (R-HSA-9021353) p-S68-ELF3 [nucleoplasm] (R-HSA-9021349)	0.463	2
UniProt:Q4KRW3 Q4KRW3			0.463	2
UniProt:P21980 TGM2			0.463	3
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.463	4
UniProt:Q92784-2 DPF3			0.462	3
UniProt:Q92784-1 DPF3			0.462	3
UniProt:P45481 Crebbp	4	CREBBP [nucleoplasm] (R-MMU-193545) Crebbp [nucleoplasm] (R-MMU-556795) Foxo4-S-S-Crebbp [nucleoplasm] (R-MMU-9617719) monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm] (R-MMU-3927936)	0.462	2

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