Reactome | RELA [nucleoplasm]

RELA [nucleoplasm]

Stable Identifier

R-HSA-177676

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NFkB3, Nuclear factor NF-kappa-B p65 subunit, Transcription factor p65

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Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of immune response proteins (Homo sapiens)
        
        PIAS3 SUMOylates RELA with SUMO3 (Homo sapiens)
        
        RELA:RELA:DNA [nucleoplasm] (Homo sapiens)
        
        NF-kB p65:p65 [nucleoplasm] (Homo sapiens)
        
        RELA [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q04206 RELA

Gene Names

RELA, NFKB3

Chain

chain:1-551

Reference Genes

BioGPS Gene:5970 RELA

COSMIC (genes):RELA RELA

CTD Gene:5970 RELA

dbSNP Gene:5970 RELA

ENSEMBL:ENSG00000173039 RELA

HGNC:9955 RELA

KEGG:hsa:5970 RELA

Monarch:5970 RELA

NCBI Gene:5970 RELA

OMIM:164014 RELA

UCSC:Q04206 RELA

Reference Transcript

Participates

as a component of

Other forms of this molecule

RELA [cytosol]

p-S276-RELA [nucleoplasm]

p-S276,5xAcK-RELA [nucleoplasm]

polySUMO3-K37,K122,K123-RELA [nucleoplasm]

p-S536-RELA [nucleoplasm]

MeK310-RELA [nucleoplasm]

Inferred To

Dif [nucleoplasm] (Drosophila melanogaster)

RELA [nucleoplasm] (Bos taurus)

RELA [nucleoplasm] (Canis familiaris)

RELA [nucleoplasm] (Gallus gallus)

RELA [nucleoplasm] (Sus scrofa)

Homologues of RELA [nucleoplasm] (Drosophila melanogaster)

Rela [nucleoplasm] (Mus musculus)

Rela [nucleoplasm] (Rattus norvegicus)

dl [nucleoplasm] (Drosophila melanogaster)

rel [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_001230913.1, NP_001138610.1, NP_068810.3

Guide to Pharmacology - Targets

3280

OpenTargets

ENSG00000173039

ENSEMBL

ENST00000406246, ENSP00000311508, ENSG00000173039, ENST00000308639, ENSP00000384273

ZINC - Substances

TF65_HUMAN

ZINC - Biogenic

TF65_HUMAN

ZINC target

Q04206

PRO

Q04206

GlyGen

Q04206

PDB

7O3Q, 6NV2, 7O6F, 7NZ6, 7BIW, 7O3F, 2O61, 7O3A, 7NSV, 7NYE, 7NLA, 7BJW, 6QHL, 7NYG, 7NYF, 6YOW, 7O5U, 7O5P, 3RC0, 7NZK, 6YP2, 7NJB, 7O5A, 7O5C, 7O5G, 4KV1, 6YOY, 7NWS, 5U4K, 7NXT, 7NQP, 7NMH, 7NXS, 7NR7, 7NZG, 7NM9, 7O6O, 7BI3, 7BKH, 7NXW, 7NV4, 7O6M, 7LF4, 7O6K, 7O6G, 7O6I, 7O3P, 7O3R, 7BIY, 7O3S, 6YQ2, 7BIQ, 7O59, 6YPL, 7NM1, 7NVI, 7BJF, 7O57, 5URN, 7LET, 7NM3, 3GUT, 7NK5, 7NLE, 7BJL, 6YP3, 6YP8, 7O5S, 7NK3, 7O5X, 7BJB, 7LEU, 7O5D, 7O5F, 7NZV, 7O5O, 6YOX, 4KV4, 3QXY, 2LSP, 7NY4, 7O34, 7NJ9, 6QHM, 6YPY, 1NFI, 7O6J, 7NXY

ZINC - Investigational

TF65_HUMAN

ZINC - Metabolites

TF65_HUMAN

GeneCards

RELA

HPA

ENSG00000173039-RELA

Pharos - Targets

Q04206

Orphanet

RELA

ZINC - Predictions - Purchasable

TF65_HUMAN

Interactors (105)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25963 NFKBIA	9	NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) PolyUb-NFKBIA [cytosol] (R-HSA-6782960)	0.977	27
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557)	0.924	16
UniProt:NFKBIA ENSG00000100906			0.905	8
UniProt:Q15653 NFKBIB	3	NFKBIB [cytosol] (R-HSA-168132) p-S19,S23-NFKBIB [cytosol] (R-HSA-177670) p-S19,S23-Ub-NFKBIB [cytosol] (R-HSA-1168571)	0.887	10
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.832	9
UniProt:O60885 BRD4	1	BRD4 [nucleoplasm] (R-HSA-9680425)	0.811	8
UniProt:P23396 RPS3	2	RPS3 [cytosol] (R-HSA-72369) RPS3 [nucleoplasm] (R-HSA-6798714)	0.797	8
UniProt:P19838-PRO_0000030311 NFKB1			0.793	7
IntAct:EBI-1566585 IL8			0.788	9
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.77	6
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.757	6
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.755	4
UniProt:Q8WTS6 SETD7	1	SETD7 [nucleoplasm] (R-HSA-1183221)	0.737	12
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.729	5
UniProt:Q01201 RELB	2	RELB [nucleoplasm] (R-HSA-5607656) RELB [cytosol] (R-HSA-5607652)	0.706	5
UniProt:Q8N668 COMMD1	2	COMMD1 [nucleoplasm] (R-HSA-8955094) COMMD1 [cytosol] (R-HSA-8955110)	0.693	7
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.693	5
UniProt:P14598 NCF1	4	NCF1 [cytosol] (R-HSA-1222296) p-6S-NCF1 [phagolysosome] (R-HSA-1996220) p-S345-NCF1 [cytosol] (R-HSA-9626824) p-6S-NCF1 [cytosol] (R-HSA-9626854)	0.682	8
UniProt:O15111 CHUK	4	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615) p-Y187,Y198-CHUK [cytosol] (R-HSA-9861501)	0.669	3
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.659	5
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.658	4
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.656	3
UniProt:Q13568 IRF5	3	IRF5 [cytosol] (R-HSA-1015676) p-S446-IRF5 [cytosol] (R-HSA-9860271) p-S446-IRF5 [nucleoplasm] (R-HSA-9860304)	0.656	6
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.656	6
IntAct:EBI-2213855 BIRC3			0.643	3
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.639	5
UniProt:Q08211 DHX9	3	DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168) DHX9 [nucleoplasm] (R-HSA-53517)	0.625	4
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.625	5
UniProt:P18847-3 ATF3			0.623	5
UniProt:O00221 NFKBIE	3	NFKBIE [cytosol] (R-HSA-1168580) p-S157,S161-NFKBIE [cytosol] (R-HSA-1168561) p-S157,S161-Ub-NFKBIE [cytosol] (R-HSA-1168563)	0.621	3
UniProt:O00255-2 MEN1			0.602	4
UniProt:Q8N6T7 SIRT6	1	SIRT6 [nucleoplasm] (R-HSA-5685963)	0.602	4
UniProt:Q9ESU6 BRD4			0.602	6
IntAct:EBI-10826665 NKILA			0.599	6
UniProt:Q9BQ69 MACD1			0.599	7
UniProt:Q53EL6 PDCD4	1	PDCD4 [cytosol] (R-HSA-5432887)	0.599	6
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.592	4
UniProt:P46695 IER3	1	IER3 [cytosol] (R-HSA-6811515)	0.591	6
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.591	6
UniProt:Q8X834 Q8X834			0.59	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926)	0.589	3
UniProt:P17612 PRKACA	4	PRKACA [cytosol] (R-HSA-57844) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.581	3
UniProt:Q99612 KLF6			0.576	6
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.573	3
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.558	4
UniProt:Q13625-2 TP53BP2			0.557	6
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.556	3
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.556	5
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:O41974 O41974			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN [extracellular region] (R-HSA-6806510) GSN [secretory granule lumen] (R-HSA-6801486) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:P06307 CCK	1	CCK [extracellular region] (R-HSA-388539)	0.556	3
UniProt:P22736-1 NR4A1			0.544	3
UniProt:Q8VIM5-1 MYOCD			0.544	2
UniProt:Q8IXJ6 SIRT2	1	SIRT2 [cytosol] (R-HSA-2161118)	0.544	2
UniProt:P25791 LMO2	1	LMO2 [nucleoplasm] (R-HSA-8956513)	0.543	3
UniProt:O75582 RPS6KA5	3	p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm] (R-HSA-198683) RPS6KA5 [nucleoplasm] (R-HSA-198657) RPS6KA5 [cytosol] (R-HSA-772525)	0.536	2
UniProt:Q7Z417 NUFP2			0.527	2
IntAct:EBI-6726290 ICAM1			0.527	3
UniProt:CCL2 ENSG00000108691			0.527	3
UniProt:P12273 PIP	1	PIP [extracellular region] (R-HSA-5252061)	0.527	2
UniProt:TNF ENSG00000204490			0.527	3
IntAct:EBI-9873017 BIRC2			0.527	2
UniProt:Q9UKB1 FBXW11	2	FBXW11 [cytosol] (R-HSA-976035) FBXW11 [nucleoplasm] (R-HSA-9953055)	0.527	2
UniProt:IL2 ENSG00000109471			0.527	2
IntAct:EBI-1550784 CDKN1A			0.527	2
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.527	2
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.524	3
IntAct:EBI-10052614 ICAM1			0.524	3
UniProt:P0C774 V			0.524	3
UniProt:P10226 PAP			0.524	6
UniProt:Q96JB5 CK5P3			0.524	4
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.524	2
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.519	5
UniProt:P69976 SCTL			0.508	2
UniProt:A0A2U2H0Y9 A0A2U2H0Y9			0.508	2
UniProt:P31491 YERA			0.508	2
UniProt:P53779 MAPK10	3	p-T221,Y223-MAPK10 [nucleoplasm] (R-HSA-450311) p-T221,Y223-MAPK10 [cytosol] (R-HSA-450214) MAPK10 [cytosol] (R-HSA-450352)	0.508	2
UniProt:A0A384KL23 A0A384KL23			0.508	2
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.499	2
IntAct:EBI-958860 BCL10			0.499	2
UniProt:Q9H9B1 EHMT1	1	EHMT1 [nucleoplasm] (R-HSA-1183226)	0.499	3
UniProt:B3CRR2 B3CRR2			0.499	3
IntAct:EBI-10021116 CCL5-DERIVED			0.499	3
IntAct:EBI-10021813 CCL5			0.499	4
UniProt:Q96SN8 CDK5RAP2	1	CDK5RAP2 [cytosol] (R-HSA-380282)	0.499	3
UniProt:O15294 OGT	2	OGT [cytosol] (R-HSA-9687814) OGT [nucleoplasm] (R-HSA-3321845)	0.499	2
IntAct:EBI-10021565 CCL5-DERIVED			0.499	2
UniProt:B3CTB0 B3CTB0			0.499	2
UniProt:P19838-2 NFKB1			0.483	3
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.463	4
UniProt:Q13148 TADBP			0.463	3
UniProt:P78545 ELF3	2	ELF3 [nucleoplasm] (R-HSA-9021353) p-S68-ELF3 [nucleoplasm] (R-HSA-9021349)	0.463	2
UniProt:Q4KRW3 M21			0.463	2
UniProt:O75531 BANF1	4	p-T2,T3,S4-BANF1 [cytosol] (R-HSA-2995375) BANF1 [cytosol] (R-HSA-175371) BANF1 [nucleoplasm] (R-HSA-175030) p-T2,T3,S4-BANF1 [nucleoplasm] (R-HSA-2993896)	0.463	3
UniProt:P21980 TGM2			0.463	3
UniProt:P45481 Crebbp	4	Crebbp [nucleoplasm] (R-MMU-193545) Crebbp [nucleoplasm] (R-MMU-556795) Foxo4-S-S-Crebbp [nucleoplasm] (R-MMU-9617719) monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm] (R-MMU-3927936)	0.462	2
UniProt:Q92784-2 DPF3			0.462	3
UniProt:Q92784-1 DPF3			0.462	3

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