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RELA [nucleoplasm]
Stable Identifier
R-HSA-177676
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NFkB3, Nuclear factor NF-kappa-B p65 subunit, Transcription factor p65
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
Activated CEBPB and NFKB complex bind IL6 promoter (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL6 gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Activated CEBPB and NFKB complex bind IL8 promoter (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL8 Gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL6 gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Stimulation of IL8 transcription in senescent cells (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL8 Gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
Regulation of NFE2L2 gene expression (Homo sapiens)
NFkB binds the NFE2L2 gene (Homo sapiens)
NFE2L2 gene:NFkB complex [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
NFkB dependent NFE2L2 expression (Homo sapiens)
NFE2L2 gene:NFkB complex [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
SETD6 methylates RELA in the NFkB complex (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of PPARG (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
Expression of NLRP3 gene (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by VENTX (Homo sapiens)
Activated CEBPB and NFKB complex bind IL6 promoter (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL6 gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL6 gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
NF-kappaB translocates from the cytosol to the nucleus (Homo sapiens)
NF-kappaB p50,p65,c-Rel dimer [nucleoplasm] (Homo sapiens)
NF-kB p65:p65 [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 processing (Homo sapiens)
Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CD209 (DC-SIGN) signaling (Homo sapiens)
Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A/inflammasome pathway (Homo sapiens)
IL1B gene is transcribed (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (Homo sapiens)
NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
RIP-mediated NFkB activation via ZBP1 (Homo sapiens)
NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
Expression of NLRP3 gene (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of immune response proteins (Homo sapiens)
PIAS3 SUMOylates RELA with SUMO3 (Homo sapiens)
RELA:RELA:DNA [nucleoplasm] (Homo sapiens)
NF-kB p65:p65 [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
NF-kB is activated and signals survival (Homo sapiens)
NF-kB migrates to the nucleus and turns on transcription (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q04206 RELA
Gene Names
RELA, NFKB3
Chain
chain:1-551
Reference Genes
BioGPS Gene:5970 RELA
COSMIC (genes):RELA RELA
CTD Gene:5970 RELA
dbSNP Gene:5970 RELA
ENSEMBL:ENSG00000173039 RELA
HGNC:9955 RELA
KEGG:hsa:5970 RELA
Monarch:5970 RELA
NCBI Gene:5970 RELA
OMIM:164014 RELA
UCSC:Q04206 RELA
Reference Transcript
RefSeq:NM_001243984.1 RELA
RefSeq:NM_001145138.2 RELA
RefSeq:NM_021975.3 RELA
Participates
as a component of
NF-kB p65:p65 [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Other forms of this molecule
RELA [cytosol]
p-S276-RELA [nucleoplasm]
p-S276,5xAcK-RELA [nucleoplasm]
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
p-S536-RELA [nucleoplasm]
MeK310-RELA [nucleoplasm]
Inferred To
Dif [nucleoplasm]
(Drosophila melanogaster)
RELA [nucleoplasm]
(Bos taurus)
RELA [nucleoplasm]
(Canis familiaris)
RELA [nucleoplasm]
(Gallus gallus)
RELA [nucleoplasm]
(Sus scrofa)
Homologues of RELA [nucleoplasm]
(Drosophila melanogaster)
Rela [nucleoplasm]
(Mus musculus)
Rela [nucleoplasm]
(Rattus norvegicus)
dl [nucleoplasm]
(Drosophila melanogaster)
rel [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_001230913.1
,
NP_001138610.1
,
NP_068810.3
Guide to Pharmacology - Targets
3280
OpenTargets
ENSG00000173039
ENSEMBL
ENST00000406246
,
ENSP00000311508
,
ENSG00000173039
,
ENST00000308639
,
ENSP00000384273
ZINC - Substances
TF65_HUMAN
ZINC - Biogenic
TF65_HUMAN
ZINC target
Q04206
PRO
Q04206
GlyGen
Q04206
PDB
7O3Q
,
6NV2
,
7O6F
,
7NZ6
,
7BIW
,
7O3F
,
2O61
,
7O3A
,
7NSV
,
7NYE
,
7NLA
,
7BJW
,
6QHL
,
7NYG
,
7NYF
,
6YOW
,
7O5U
,
7O5P
,
3RC0
,
7NZK
,
6YP2
,
7NJB
,
7O5A
,
7O5C
,
7O5G
,
4KV1
,
6YOY
,
7NWS
,
5U4K
,
7NXT
,
7NQP
,
7NMH
,
7NXS
,
7NR7
,
7NZG
,
7NM9
,
7O6O
,
7BI3
,
7BKH
,
7NXW
,
7NV4
,
7O6M
,
7LF4
,
7O6K
,
7O6G
,
7O6I
,
7O3P
,
7O3R
,
7BIY
,
7O3S
,
6YQ2
,
7BIQ
,
7O59
,
6YPL
,
7NM1
,
7NVI
,
7BJF
,
7O57
,
5URN
,
7LET
,
7NM3
,
3GUT
,
7NK5
,
7NLE
,
7BJL
,
6YP3
,
6YP8
,
7O5S
,
7NK3
,
7O5X
,
7BJB
,
7LEU
,
7O5D
,
7O5F
,
7NZV
,
7O5O
,
6YOX
,
4KV4
,
3QXY
,
2LSP
,
7NY4
,
7O34
,
7NJ9
,
6QHM
,
6YPY
,
1NFI
,
7O6J
,
7NXY
ZINC - Investigational
TF65_HUMAN
ZINC - Metabolites
TF65_HUMAN
GeneCards
RELA
HPA
ENSG00000173039-RELA
Pharos - Targets
Q04206
Orphanet
RELA
ZINC - Predictions - Purchasable
TF65_HUMAN
Interactors (105)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P25963 NFKBIA
9
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
0.977
27
UniProt:P19838 NFKB1
8
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
0.924
16
UniProt:NFKBIA ENSG00000100906
0.905
8
UniProt:Q15653 NFKBIB
3
NFKBIB [cytosol]
(R-HSA-168132)
p-S19,S23-NFKBIB [cytosol]
(R-HSA-177670)
p-S19,S23-Ub-NFKBIB [cytosol]
(R-HSA-1168571)
0.887
10
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.832
9
UniProt:O60885 BRD4
1
BRD4 [nucleoplasm]
(R-HSA-9680425)
0.811
8
UniProt:P23396 RPS3
2
RPS3 [cytosol]
(R-HSA-72369)
RPS3 [nucleoplasm]
(R-HSA-6798714)
0.797
8
UniProt:P19838-PRO_0000030311 NFKB1
0.793
7
IntAct:EBI-1566585 IL8
0.788
9
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.77
6
UniProt:Q92793 CREBBP
4
CREBBP [nucleoplasm]
(R-HSA-193545)
CREBBP [cytosol]
(R-HSA-9756493)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
0.757
6
UniProt:O14920 IKBKB
3
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
0.755
4
UniProt:Q8WTS6 SETD7
1
SETD7 [nucleoplasm]
(R-HSA-1183221)
0.737
12
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.729
5
UniProt:Q01201 RELB
2
RELB [nucleoplasm]
(R-HSA-5607656)
RELB [cytosol]
(R-HSA-5607652)
0.706
5
UniProt:Q8N668 COMMD1
2
COMMD1 [nucleoplasm]
(R-HSA-8955094)
COMMD1 [cytosol]
(R-HSA-8955110)
0.693
7
UniProt:O95863 SNAI1
1
SNAI1 [nucleoplasm]
(R-HSA-2980903)
0.693
5
UniProt:P14598 NCF1
4
NCF1 [cytosol]
(R-HSA-1222296)
p-6S-NCF1 [phagolysosome]
(R-HSA-1996220)
p-S345-NCF1 [cytosol]
(R-HSA-9626824)
p-6S-NCF1 [cytosol]
(R-HSA-9626854)
0.682
8
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.669
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.659
5
UniProt:Q09472 EP300
5
EP300 [nucleoplasm]
(R-HSA-381325)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
0.658
4
UniProt:P68400 CSNK2A1
2
CSNK2A1 [cytosol]
(R-HSA-201713)
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
0.656
3
UniProt:Q13568 IRF5
3
IRF5 [cytosol]
(R-HSA-1015676)
p-S446-IRF5 [cytosol]
(R-HSA-9860271)
p-S446-IRF5 [nucleoplasm]
(R-HSA-9860304)
0.656
6
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.656
6
IntAct:EBI-2213855 BIRC3
0.643
3
UniProt:Q9UBK9 UXT
1
UXT [nucleoplasm]
(R-HSA-9007484)
0.639
5
UniProt:Q08211 DHX9
3
DHX9 [cytosol]
(R-HSA-847700)
p-DHX9 [cytosol]
(R-HSA-9836168)
DHX9 [nucleoplasm]
(R-HSA-53517)
0.625
4
UniProt:Q16236 NFE2L2
13
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
0.625
5
UniProt:P18847-3 ATF3
0.623
5
UniProt:O00221 NFKBIE
3
NFKBIE [cytosol]
(R-HSA-1168580)
p-S157,S161-NFKBIE [cytosol]
(R-HSA-1168561)
p-S157,S161-Ub-NFKBIE [cytosol]
(R-HSA-1168563)
0.621
3
UniProt:O00255-2 MEN1
0.602
4
UniProt:Q8N6T7 SIRT6
1
SIRT6 [nucleoplasm]
(R-HSA-5685963)
0.602
4
UniProt:Q9ESU6 BRD4
0.602
6
IntAct:EBI-10826665 NKILA
0.599
6
UniProt:Q9BQ69 MACD1
0.599
7
UniProt:Q53EL6 PDCD4
1
PDCD4 [cytosol]
(R-HSA-5432887)
0.599
6
UniProt:Q14145 KEAP1
3
KEAP1 [cytosol]
(R-HSA-976038)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
0.592
4
UniProt:P46695 IER3
1
IER3 [cytosol]
(R-HSA-6811515)
0.591
6
UniProt:P67775 PPP2CA
4
PPP2CA [cytosol]
(R-HSA-165971)
PPP2CA [nucleoplasm]
(R-HSA-165978)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
0.591
6
UniProt:Q8X834 Q8X834
0.59
2
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
0.589
3
UniProt:P17612 PRKACA
4
PRKACA [cytosol]
(R-HSA-57844)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [mitochondrial matrix]
(R-HSA-9838291)
0.581
3
UniProt:Q99612 KLF6
0.576
6
UniProt:Q04206 RELA
7
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
0.573
3
UniProt:Q13625 TP53BP2
1
TP53BP2 [nucleoplasm]
(R-HSA-6799780)
0.558
4
UniProt:Q13625-2 TP53BP2
0.557
6
UniProt:P62826 RAN
2
RAN [cytosol]
(R-HSA-165540)
RAN [nucleoplasm]
(R-HSA-165528)
0.556
3
UniProt:Q9UER7 DAXX
13
DAXX [nucleoplasm]
(R-HSA-3222068)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
0.556
5
UniProt:P55212 CASP6
5
CASP6(194-293) [cytosol]
(R-HSA-266128)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
0.556
3
UniProt:O75400-2 PRPF40A
0.556
3
UniProt:O41974 O41974
0.556
3
UniProt:P13473-2 P134732
0.556
3
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
p-6Y-FGFR3 A391E [plasma membrane]
(R-HSA-2065835)
p-6Y-FGFR3 K650T [plasma membrane]
(R-HSA-2032966)
p-6Y-FGFR3 G382D [plasma membrane]
(R-HSA-2032950)
p-6Y-FGFR3 G380R [plasma membrane]
(R-HSA-2032946)
p-6Y-FGFR3 K650M [plasma membrane]
(R-HSA-2032959)
0.556
3
UniProt:Q9Y649 Q9Y649
0.556
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:P28329-3 P283293
0.556
3
UniProt:P06396 GSN
7
GSN [cytosol]
(R-HSA-350275)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN [extracellular region]
(R-HSA-6806510)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN(200-270) [extracellular region]
(R-HSA-976940)
0.556
3
UniProt:P06307 CCK
1
CCK [extracellular region]
(R-HSA-388539)
0.556
3
UniProt:P22736-1 NR4A1
0.544
3
UniProt:Q8VIM5-1 MYOCD
0.544
2
UniProt:Q8IXJ6 SIRT2
1
SIRT2 [cytosol]
(R-HSA-2161118)
0.544
2
UniProt:P25791 LMO2
1
LMO2 [nucleoplasm]
(R-HSA-8956513)
0.543
3
UniProt:O75582 RPS6KA5
3
p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm]
(R-HSA-198683)
RPS6KA5 [nucleoplasm]
(R-HSA-198657)
RPS6KA5 [cytosol]
(R-HSA-772525)
0.536
2
UniProt:Q7Z417 NUFP2
0.527
2
IntAct:EBI-6726290 ICAM1
0.527
3
UniProt:CCL2 ENSG00000108691
0.527
3
UniProt:P12273 PIP
1
PIP [extracellular region]
(R-HSA-5252061)
0.527
2
UniProt:TNF ENSG00000204490
0.527
3
IntAct:EBI-9873017 BIRC2
0.527
2
UniProt:Q9UKB1 FBXW11
2
FBXW11 [cytosol]
(R-HSA-976035)
FBXW11 [nucleoplasm]
(R-HSA-9953055)
0.527
2
UniProt:IL2 ENSG00000109471
0.527
2
IntAct:EBI-1550784 CDKN1A
0.527
2
UniProt:O00629 KPNA4
2
KPNA4 [cytosol]
(R-HSA-1176066)
KPNA4 [nucleoplasm]
(R-HSA-1176058)
0.527
2
UniProt:Q9NY61 AATF
1
AATF [cytosol]
(R-HSA-205071)
0.524
3
IntAct:EBI-10052614 ICAM1
0.524
3
UniProt:P0C774 V
0.524
3
UniProt:P10226 PAP
0.524
6
UniProt:Q96JB5 CK5P3
0.524
4
UniProt:Q8N2W9 PIAS4
2
PIAS4 [nucleoplasm]
(R-HSA-2993789)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(R-HSA-3968415)
0.524
2
UniProt:Q13485 SMAD4
20
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 G352* [cytosol]
(R-HSA-9678445)
SMAD4 S178* [cytosol]
(R-HSA-9675630)
SMAD4 G477* [cytosol]
(R-HSA-9678447)
SMAD4 G473* [cytosol]
(R-HSA-9678440)
SMAD4 S144* [cytosol]
(R-HSA-9675625)
SMAD4 E538* [cytosol]
(R-HSA-9675626)
SMAD4 E390* [cytosol]
(R-HSA-9675620)
SMAD4 S154* [cytosol]
(R-HSA-9675621)
SMAD4 E330* [cytosol]
(R-HSA-9675622)
0.519
5
UniProt:P69976 SCTL
0.508
2
UniProt:A0A2U2H0Y9 A0A2U2H0Y9
0.508
2
UniProt:P31491 YERA
0.508
2
UniProt:P53779 MAPK10
3
p-T221,Y223-MAPK10 [nucleoplasm]
(R-HSA-450311)
p-T221,Y223-MAPK10 [cytosol]
(R-HSA-450214)
MAPK10 [cytosol]
(R-HSA-450352)
0.508
2
UniProt:A0A384KL23 A0A384KL23
0.508
2
UniProt:P30153 PPP2R1A
2
PPP2R1A [cytosol]
(R-HSA-165982)
PPP2R1A [nucleoplasm]
(R-HSA-165968)
0.499
2
IntAct:EBI-958860 BCL10
0.499
2
UniProt:Q9H9B1 EHMT1
1
EHMT1 [nucleoplasm]
(R-HSA-1183226)
0.499
3
UniProt:B3CRR2 B3CRR2
0.499
3
IntAct:EBI-10021116 CCL5-DERIVED
0.499
3
IntAct:EBI-10021813 CCL5
0.499
4
UniProt:Q96SN8 CDK5RAP2
1
CDK5RAP2 [cytosol]
(R-HSA-380282)
0.499
3
UniProt:O15294 OGT
2
OGT [cytosol]
(R-HSA-9687814)
OGT [nucleoplasm]
(R-HSA-3321845)
0.499
2
IntAct:EBI-10021565 CCL5-DERIVED
0.499
2
UniProt:B3CTB0 B3CTB0
0.499
2
UniProt:P19838-2 NFKB1
0.483
3
UniProt:P40763 STAT3
12
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
0.463
4
UniProt:Q13148 TADBP
0.463
3
UniProt:P78545 ELF3
2
ELF3 [nucleoplasm]
(R-HSA-9021353)
p-S68-ELF3 [nucleoplasm]
(R-HSA-9021349)
0.463
2
UniProt:Q4KRW3 M21
0.463
2
UniProt:O75531 BANF1
4
p-T2,T3,S4-BANF1 [cytosol]
(R-HSA-2995375)
BANF1 [cytosol]
(R-HSA-175371)
BANF1 [nucleoplasm]
(R-HSA-175030)
p-T2,T3,S4-BANF1 [nucleoplasm]
(R-HSA-2993896)
0.463
3
UniProt:P21980 TGM2
0.463
3
UniProt:P45481 Crebbp
4
Crebbp [nucleoplasm]
(R-MMU-193545)
Crebbp [nucleoplasm]
(R-MMU-556795)
Foxo4-S-S-Crebbp [nucleoplasm]
(R-MMU-9617719)
monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm]
(R-MMU-3927936)
0.462
2
UniProt:Q92784-2 DPF3
0.462
3
UniProt:Q92784-1 DPF3
0.462
3
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