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EGFR dimerization
Stable Identifier
R-HSA-177922
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
EGFR dimerization (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
EGF and other growth factors induce oligomerization of their specific receptors. Inactive EGFR monomers are in equilibrium with active EGFR dimers and binding of the EGF ligand stabilizes the active dimeric form.
AAMP binding to EGFR, through an unknown mechanism, promotes EGFR dimerization, trans-autophosphorylation and downstream signaling, leading to activation of ERKs (MAPK1 and MAPK3) and expression of cyclin D1 (CCND1) (Yao et al. 2019). Positive regulation of EGFR dimerization by AAMP was shown in the context of EGF-mediated activation of EGFR signaling (Yao et al. 2019). The effect of AAMP in the context of other natural EGFR agonists (TGFA, AREG, EPGN, BTC, EREG, and HBEGF) has not been examined, but is assumed to be qualitatively similar.
Literature References
PubMed ID
Title
Journal
Year
8639530
Activation of epidermal growth factor receptor by epidermal growth factor
Kyte, J
,
Sherrill, JM
Biochemistry
1996
Participants
Input
x 2
EGFR:EGF-like ligands [plasma membrane]
(Homo sapiens)
Output
EGF-like ligands:EGFR dimer [plasma membrane]
(Homo sapiens)
Participates
as an event of
Signaling by EGFR (Homo sapiens)
This event is regulated
Positively by
Regulator
EGFR:AAMP [plasma membrane]
(Homo sapiens)
Active Unit
AAMP [cytosol]
Orthologous Events
EGFR dimerization (Bos taurus)
EGFR dimerization (Caenorhabditis elegans)
EGFR dimerization (Canis familiaris)
EGFR dimerization (Danio rerio)
EGFR dimerization (Drosophila melanogaster)
EGFR dimerization (Gallus gallus)
EGFR dimerization (Mus musculus)
EGFR dimerization (Rattus norvegicus)
EGFR dimerization (Sus scrofa)
EGFR dimerization (Xenopus tropicalis)
Authored
Castagnoli, L (2006-10-10)
Reviewed
Muthuswamy, S (2007-02-17)
Hill, DP (2023-11-02)
Created
Jassal, B (2006-04-11)
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