Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein

Stable Identifier
R-HSA-1791107
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein
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The DDIT3 (CHOP) gene is transcribed to yield mRNA and the mRNA is translated to yield protein (Bartlett et al. 1992, Carlson et al. 1993, Bruhat et al. 1997, Yoshida et al. 2000, Lee et al. 2008, Sikalidis et al. 2011). In response to amino acid starvation, transcription of DDIT3 s enhanced by ATF4 and phosphorylated ATF2 (Bruhat et al. 2000, Averous et al. 2004, Bruhat et al. 2007). In mouse, expression of Ddit3 is activated by DNA damage and by NF-Y and Atf4 in response to endoplasmic reticulum stress.
Literature References
PubMed ID Title Journal Year
10958673 ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

Yoshida, H, Okada, T, Haze, K, Yanagi, H, Yura, T, Negishi, M, Mori, K

Mol Cell Biol 2000
22802018 Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress

Takayanagi, S, Fukuda, R, Takeuchi, Y, Tsukada, S, Yoshida, K

Cell Stress Chaperones 2013
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
ATF6(1-380) [nucleoplasm] (Homo sapiens)
Regulator
NF-Y [nucleoplasm] (Homo sapiens)
Regulator
ATF4 [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Ddit3 (Rattus norvegicus)
Expression of DDIT3 (Cricetulus griseus)
Authored
May, B  (2011-10-13)
Reviewed
D'Eustachio, P  (2008-12-02)
Matthews, L  (2008-12-02)
Gillespie, ME  (2008-12-02)
Urano, F  (2010-04-30)
Created
May, B  (2011-10-21)
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