GAB1 binds phosphatidylinositol-3,4,5-trisphosphate

Stable Identifier
R-HSA-179467
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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GAB1 binds phosphatidylinositol-3,4,5-trisphosphate
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The pleckstrin homology (PH) domain of GAB1 binds to PIP3 and can target GAB1 to the plasma membrane in response to EGF stimulation. This mechanism provides a positive feedback loop with respect to PI3K activation, to enhance EGFR signalling.
Literature References
PubMed ID Title Journal Year
10648629 A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

Falasca, M, Rodrigues, GA, Schlessinger, J, Ong, SH, Zhang, Z

Mol Cell Biol 2000
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Orthologous Events
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Bos taurus)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Canis familiaris)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Drosophila melanogaster)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Gallus gallus)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Mus musculus)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Rattus norvegicus)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Sus scrofa)
GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Xenopus tropicalis)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-05-03)
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