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CD80 [plasma membrane]
Stable Identifier
R-HSA-179789
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
PI3K binds CD28 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
CD28 dependent Vav1 pathway (Homo sapiens)
Activation of Cdc42 by pVav1 (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
Activation of Rac1 by pVav1 (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
Activation of Vav1 (Homo sapiens)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
Grb2 binds CD28 (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
Translocation of Vav1 to CD28 (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
CD28:Grb2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
CD28 homodimer binds B7-1 homodimer (Homo sapiens)
CD28:B7-1 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
Gads binds CD28 (Homo sapiens)
CD28:GRAP2 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
Phosphorylation of CD28 (Homo sapiens)
CD28:B7-1,B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
CTLA4 inhibitory signaling (Homo sapiens)
CTLA-4 binds B7-1/B7-2 (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
Phosphorylation of CTLA-4 (Homo sapiens)
PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Homo sapiens)
p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
SHP2 phosphatase binds CTLA-4 (Homo sapiens)
p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Homo sapiens)
p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Homo sapiens)
p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Homo sapiens)
p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 negatively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)
IL10-downregulated plasma membrane proteins [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
B7-1 homodimer/ B7-2 [plasma membrane] (Homo sapiens)
CD80 dimer [plasma membrane] (Homo sapiens)
CD80 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P33681 CD80
Gene Names
CD80, CD28LG, CD28LG1, LAB7
Chain
signal peptide:1-34, chain:35-288
Reference Genes
BioGPS Gene:941 CD80
COSMIC (genes):CD80 CD80
CTD Gene:941 CD80
dbSNP Gene:941 CD80
ENSEMBL:ENSG00000121594 CD80
ENSEMBL_homo_sapiens_GENE:ENSG00000121594.12 CD80
HGNC:1700 CD80
KEGG Gene (Homo sapiens):941 CD80
Monarch:941 CD80
NCBI Gene:941 CD80
OMIM:112203 CD80
UCSC:P33681 CD80
Reference Transcript
RefSeq:NM_005191.3 CD80
Other Identifiers
11737171_at
11737172_a_at
11737173_at
11752860_a_at
11753503_a_at
1554519_PM_at
1554519_at
16957795
207176_PM_s_at
207176_s_at
2690901
2690902
2690903
2690904
2690906
2690912
2690913
2690916
2690921
2690922
2690923
2690924
2690926
35015_at
8089771
941
A_23_P155632
A_24_P320033
GE81477
GO:0001618
GO:0002376
GO:0002710
GO:0005515
GO:0005886
GO:0006351
GO:0006355
GO:0006955
GO:0007155
GO:0007166
GO:0009897
GO:0009967
GO:0009986
GO:0015026
GO:0016020
GO:0023052
GO:0030154
GO:0031295
GO:0032725
GO:0032743
GO:0035556
GO:0036211
GO:0042102
GO:0042110
GO:0045627
GO:0045893
GO:0046718
GO:0048018
GO:0048856
GO:0050731
GO:0060089
GO:0071222
GO:0098636
GO:0098772
HMNXSV003049606
Hs2.838.2.S1_3p_at
ILMN_1716736
M27533_s_at
PH_hs_0000099
TC03001684.hg
g4885122_3p_s_at
Participates
as a member of
IL10-downregulated plasma membrane proteins [plasma membrane] (Homo sapiens)
as a component of
CD80 dimer [plasma membrane] (Homo sapiens)
Inferred To
Homologues of CD80 [plasma membrane]
(Xenopus tropicalis)
Cd80 [plasma membrane]
(Mus musculus)
Cd80 [plasma membrane]
(Rattus norvegicus)
CD80 [plasma membrane]
(Bos taurus)
CD80 [plasma membrane]
(Canis familiaris)
CD80 [plasma membrane]
(Gallus gallus)
CD80 [plasma membrane]
(Sus scrofa)
cd86 [plasma membrane]
(Xenopus tropicalis)
LOC100489320 [plasma membrane]
(Xenopus tropicalis)
cd80 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_005182.1
Guide to Pharmacology - Targets
2744
OpenTargets
ENSG00000121594
GeneCards
P33681
HPA
ENSG00000121594-CD80
Ensembl
ENSP00000264246
,
ENSG00000121594
,
ENSP00000418364
,
ENST00000264246
,
ENST00000478182
,
ENSP00000373165
,
ENST00000383669
PRO
P33681
Pharos - Targets
P33681
PDB
1DR9
,
7TPS
,
1I8L
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NZQ7 CD274
1
CD274 [plasma membrane]
(R-HSA-3211776)
0.876
11
UniProt:P16410 CTLA4
2
p-Y201,Y218-CTLA4 [plasma membrane]
(R-HSA-388754)
CTLA4 [plasma membrane]
(R-HSA-179764)
0.78
7
UniProt:P08138 NGFR
7
NGFR [plasma membrane]
(R-HSA-193664)
NGFR(29-250) [extracellular region]
(R-HSA-194470)
NGFR(251-427) [plasma membrane]
(R-HSA-194476)
NGFR(251-427) [endosome]
(R-HSA-209541)
NGFR(273-427) [cytosol]
(R-HSA-194458)
NGFR(251-272) [plasma membrane]
(R-HSA-194509)
NGFR(273-427) [nucleoplasm]
(R-HSA-197473)
0.544
3
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