p-6Y-EGFR [plasma membrane]

Stable Identifier
R-HSA-179803
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Phospho-EGFR, Phosphorylated Epidermal Growth Factor Receptor
Icon
p-6Y-EGFR [plasma membrane] icon
p-6Y-EGFR [plasma membrane] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P00533 EGFR
Gene Names
EGFR, ERBB, ERBB1, HER1
Chain
signal peptide:1-24, chain:25-1210
Reference Genes
BioGPS Gene:1956 EGFR
COSMIC (genes):EGFR EGFR
CTD Gene:1956 EGFR
dbSNP Gene:1956 EGFR
ENSEMBL:ENSG00000146648.20 EGFR
HGNC:3236 EGFR
KEGG Gene (Homo sapiens):1956 EGFR
Monarch:1956 EGFR
NCBI Gene:1956 EGFR
OMIM:131550 EGFR
UCSC:P00533 EGFR
Reference Transcript
Other Identifiers
0000840253
0002940025
0005900148
0006350504
11725102_at
11725103_s_at
11725104_a_at
11733760_a_at
11738815_at
11742247_a_at
11751983_a_at
1537_at
1565483_PM_at
1565483_at
1565484_PM_x_at
1565484_x_at
17046135
1956
201983_PM_s_at
201983_s_at
201984_PM_s_at
201984_s_at
210984_PM_x_at
210984_x_at
211550_PM_at
211550_at
211607_PM_x_at
211607_x_at
224999_PM_at
224999_at
3002641
3002642
3002729
3002731
3002733
3002738
3002741
3002743
3002747
3002749
3002750
3002751
3002753
3002757
3002760
3002761
3002763
3002767
3002769
3002770
3002771
3002775
3002776
3002778
3002779
3002786
3002798
3002800
3002801
3002802
3002806
3002807
3002808
3002811
3002812
3002813
3002814
3002815
3002816
3002817
3002818
3002819
3002820
3002821
3002822
3002823
3002824
3002825
37327_at
48285_at
65700_at
8132860
A_14_P106592
A_23_P215790
A_33_P3351944
A_33_P3351955
GE59632
GO:0000139
GO:0000165
GO:0000166
GO:0000278
GO:0000902
GO:0001503
GO:0001618
GO:0001892
GO:0001934
GO:0001942
GO:0003677
GO:0003682
GO:0003690
GO:0004672
GO:0004709
GO:0004713
GO:0004714
GO:0004888
GO:0005006
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005635
GO:0005737
GO:0005768
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0005887
GO:0005925
GO:0006260
GO:0006281
GO:0006351
GO:0006355
GO:0006468
GO:0007155
GO:0007165
GO:0007166
GO:0007169
GO:0007171
GO:0007173
GO:0007202
GO:0007435
GO:0007611
GO:0008092
GO:0008283
GO:0008284
GO:0008544
GO:0009925
GO:0009986
GO:0010008
GO:0010750
GO:0012501
GO:0014066
GO:0016020
GO:0016021
GO:0016301
GO:0016310
GO:0016323
GO:0016740
GO:0018108
GO:0019899
GO:0019900
GO:0019903
GO:0021795
GO:0022414
GO:0023052
GO:0030054
GO:0030139
GO:0030154
GO:0030163
GO:0030235
GO:0030296
GO:0030297
GO:0030307
GO:0030335
GO:0030669
GO:0031047
GO:0031410
GO:0031625
GO:0031901
GO:0031965
GO:0032587
GO:0032991
GO:0033138
GO:0033674
GO:0034614
GO:0036211
GO:0038083
GO:0038134
GO:0042059
GO:0042127
GO:0042177
GO:0042327
GO:0042802
GO:0043066
GO:0043226
GO:0043235
GO:0043406
GO:0044214
GO:0045121
GO:0045296
GO:0045737
GO:0045739
GO:0045740
GO:0045893
GO:0045944
GO:0046328
GO:0046718
GO:0046777
GO:0048146
GO:0048408
GO:0048471
GO:0048546
GO:0048856
GO:0048870
GO:0050673
GO:0050679
GO:0050730
GO:0050877
GO:0050896
GO:0050999
GO:0051015
GO:0051117
GO:0051205
GO:0051897
GO:0060089
GO:0060571
GO:0061024
GO:0061029
GO:0061098
GO:0065003
GO:0070141
GO:0070372
GO:0070374
GO:0070435
GO:0071230
GO:0071276
GO:0071363
GO:0071364
GO:0071392
GO:0072659
GO:0090263
GO:0097489
GO:0097708
GO:0098590
GO:0098609
GO:0098772
GO:0140096
GO:1900020
GO:1900087
GO:1901224
GO:1903078
GO:1903800
GO:1905208
HMNXSV003006702
HMNXSV003057307
Hs.279898.0.S1_3p_at
Hs.77432.0.S1_3p_a_at
Hs2.367845.1.S1_3p_at
Hs2.367845.1.S1_3p_x_at
ILMN_1696521
ILMN_1728858
ILMN_1755535
ILMN_1798975
ILMN_1905285
PH_hs_0004462
PH_hs_0014421
TC07000328.hg
TC07002321.hg
TC07002322.hg
X00588_at
g12002211_3p_at
g1628549_3p_s_at
g4885198_3p_a_at
p26428
Participates
as a component of
as a member of
Other forms of this molecule
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
p-5Y-EGFRvIII [plasma membrane]
EGFRvIII [plasma membrane]
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
p-6Y-EGFR L858R;T790M [plasma membrane]
p-6Y-EGFR M766_A767insASV [plasma membrane]
p-6Y-EGFR D770_N771insNPH [plasma membrane]
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
p-6Y-EGFR D770_N771insNPG [plasma membrane]
p-6Y-EGFR E746_A750del [plasma membrane]
p-6Y-EGFR L858R [plasma membrane]
p-6Y-EGFR G719S [plasma membrane]
p-6Y-EGFR L747_P753delinsS [plasma membrane]
p-6Y-EGFR L747_A750delinsP [plasma membrane]
p-6Y-EGFR L747_T751del [plasma membrane]
p-6Y-EGFR L747_S752del [plasma membrane]
p-6Y-EGFR L747_T751delinsP [plasma membrane]
p-6Y-EGFR E746_T751delinsA [plasma membrane]
p-6Y-EGFR E746_S752delinsV [plasma membrane]
p-6Y-EGFR L861Q [plasma membrane]
p-6Y-EGFR A289V [plasma membrane]
p-6Y-EGFR T263P [plasma membrane]
p-6Y-EGFR G598V [plasma membrane]
p-6Y-EGFR R108K [plasma membrane]
p-6Y-EGFR A289T [plasma membrane]
p-6Y-EGFR G719C [plasma membrane]
p-6Y-EGFR A289D [plasma membrane]
p-6Y-EGFR G719A [plasma membrane]
EGFR L858R;T790M [plasma membrane]
EGFR E746_A750del;T790M [plasma membrane]
EGFR D770_N771insNPG [plasma membrane]
EGFR V738_K739insKIPVAI [plasma membrane]
EGFR M766_A767insASV [plasma membrane]
EGFR D770_N771insNPH [plasma membrane]
EGFR L858R [plasma membrane]
EGFR G719S [plasma membrane]
EGFR E746_A750del [plasma membrane]
EGFR L747_P753delinsS [plasma membrane]
EGFR A289V [plasma membrane]
EGFR L747_T751delinsP [plasma membrane]
EGFR L747_T751del [plasma membrane]
EGFR A289D [plasma membrane]
EGFR L861Q [plasma membrane]
EGFR R108K [plasma membrane]
EGFR L747_A750delinsP [plasma membrane]
EGFR E746_T751delinsA [plasma membrane]
EGFR G719A [plasma membrane]
EGFR A289T [plasma membrane]
EGFR E746_S752delinsV [plasma membrane]
EGFR G719C [plasma membrane]
EGFR T263P [plasma membrane]
EGFR G598V [plasma membrane]
EGFR L747_S752del [plasma membrane]
EGFR [endosome membrane]
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
p-4Y-EGFR [plasma membrane]
EGFR [plasma membrane]
p-Y1086,Y1101-EGFR [plasma membrane]
Inferred To
phospho-p-6Y-EGFR [plasma membrane] (Bos taurus)
phospho-p-6Y-EGFR [plasma membrane] (Caenorhabditis elegans)
phospho-p-6Y-EGFR [plasma membrane] (Canis familiaris)
phospho-p-6Y-EGFR [plasma membrane] (Danio rerio)
phospho-p-6Y-EGFR [plasma membrane] (Drosophila melanogaster)
phospho-p-6Y-EGFR [plasma membrane] (Gallus gallus)
phospho-p-6Y-EGFR [plasma membrane] (Mus musculus)
phospho-p-6Y-EGFR [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-EGFR [plasma membrane] (Sus scrofa)
phospho-p-6Y-EGFR [plasma membrane] (Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 992
Coordinate
992
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1045
Coordinate
1045
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1068
Coordinate
1068
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1086
Coordinate
1086
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1148
Coordinate
1148
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1173
Coordinate
1173
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
5X2F, 5UGA, 5HCY, 5UWD, 5JEB, 4I22, 3OB2, 6D8E, 4I21, 6JZ0, 2EB2, 5HG7, 4JRV, 3BEL, 7JXQ, 5ZTO, 6WXN, 5XGM, 1IVO, 4RJ4, 5J9Y, 7LEN, 5CNN, 3C09, 3W33, 5X2C, 7KY0, 7LG8, 5CZI, 5UG9, 5GMP, 1M14, 2ITQ, 7JXL, 3IKA, 6V66, 1XKK, 4RJ8, 5FEE, 2N5S, 5FED, 5HCX, 3UG2, 5HG8, 6LUD, 2M0B, 6P1L, 2ITX, 3PFV, 1NQL, 4WD5, 6DUK, 7SZ0, 6V5P, 2ITU, 4WKQ, 7A6J, 4R3R, 4R5S, 3G5Y, 2GS2, 6WA2, 7B85, 7K1I, 7A6K, 5CZH, 5HIC, 5CAV, 4G5J, 3W2R, 4UIP, 4RIW, 6JWL, 5ZWJ, 3W2Q, 5C8N, 2JIT, 4KRP, 2JIU, 3GOP, 3UG1, 5C8M, 7LGS, 2ITP, 6TFU, 6S9B, 5Y25, 2J5E, 7JXW, 6S9C, 7A6I, 3OP0, 4ZSE, 2GS7, 5CAN, 5EM8, 4LL0, 5XGN, 5CAL, 6VH4, 5EM7, 4ZJV, 2ITV, 4LI5, 5WB8, 2EB3, 3P0Y, 4LRM, 4I24, 5XDL, 5EDP, 4JR3, 7JXM, 7TVD, 7AEM, 2RF9, 4RJ7, 6Z4D, 5X28, 6TFV, 3LZB, 7SZ1, 4KRO, 6VHN, 6TFZ, 5SX5, 5X2A, 4R3P, 3B2U, 3G5V, 5WB7, 6TG0, 7LTX, 3VRP, 2RGP, 6P8Q, 6ARU, 5HCZ, 3VRR, 7AEI, 4I23, 3GT8, 4UV7, 3VJO, 5UGB, 1MOX, 2ITZ, 2M20, 5UGC, 6JRJ, 7SYD, 6WAK, 7A2A, 5XWD, 5D41, 2GS6, 5SX4, 4I20, 7LFR, 4KRM, 4LQM, 5J9Z, 4JQ8, 3BUO, 5XDK, 6S8A, 5X2K, 6JX0, 7JXP, 1YY9, 5HG9, 4I1Z, 5CAQ, 4RJ6, 6V6K, 4WRG, 5GNK, 4HJO, 6XL4, 4KRL, 5HG5, 2J5F, 7SZ5, 5UG8, 6S89, 6V5N, 4RIY, 2J6M, 7JXI, 4JQ7, 4G5P, 5FEQ, 3W32, 3NJP, 5EDR, 5HIB, 2JIV, 3QWQ, 5EM5, 3W2S, 3POZ, 6B3S, 5CAU, 5GTZ, 5EDQ, 7KXZ, 5X26, 3W2P, 4TKS, 2ITO, 4ZAU, 3VJN, 6JX4, 6LUB, 5C8K, 5X27, 7SYE, 5CAP, 5LV6, 5CAO, 2ITN, 1M17, 1Z9I, 7OXB, 6V6O, 6VHP, 5U8L, 7LFS, 2ITT, 6JRX, 7OM4, 6S9D, 5EM6, 6JXT, 6P1D, 7SZ7, 7JXK, 2RFD, 5CAS, 5GTY, 3W2O, 6Z4B, 5Y9T, 2ITW, 6JRK, 6TFW, 7K1H, 5CNO, 4RJ5, 2ITY, 5YU9, 4RIX, 6TG1, 3B2V, 6TFY, 2RFE, 2KS1
ZINC - Investigational
ZINC - Metabolites
GeneCards
HPA
Ensembl
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (312)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P62993 GRB2  1 0.982 58
 UniProt:P00533 EGFR  20 0.981 29
 UniProt:P29353 SHC1  5 0.976 44
 UniProt:P01133 EGF  5 0.973 29
 UniProt:P22681 CBL  20 0.964 26
 UniProt:P04626 ERBB2  20 0.954 25
 UniProt:P40763 STAT3  12 0.919 15
 UniProt:P21860 ERBB3      0.91 13
 UniProt:P12931 SRC  6 0.9 9
 UniProt:P18031 PTPN1  2 0.898 9
 UniProt:P08238 HSP90AB1  6 0.89 10
 UniProt:Q9UJM3 ERRFI      0.866 14
 UniProt:P27348 YWHAQ  1 0.854 7
 UniProt:P19174 PLCG1  6 0.85 6
 UniProt:P31947 SFN  1 0.833 9
 UniProt:P62158 CALM      0.828 6
 UniProt:P16333 NCK1  2 0.823 6
 UniProt:Q06124 PTPN11  4 0.821 8
 UniProt:P07948 LYN  7 0.82 7
 UniProt:P15941 MUC1  19 0.819 6
 UniProt:Q03135 CAV1  5 0.813 7
 UniProt:O00750 PIK3C2B  1 0.811 10