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GRB2 events in EGFR signaling
Stable Identifier
R-HSA-179812
DOI
10.3180/REACT_12606.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
GRB2 events in EGFR signaling (Homo sapiens)
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Autophosphorylated EGFR tyrosine residues are docking sites for many downstream effectors in EGFR signaling. The adaptor protein GRB2 binds to phosphotyrosine residues in the C-tail of EGFR through its SH2 domain. GRB2 is constitutively associated with SOS, a guanine nucleotide exchange factor of RAS. GRB2 binding to phosphorylated EGFR results in the recruitment of SOS to the plasma membrane where it comes in proximity to RAS. This mechanism has been seen to be the model for RAS activation.
Literature References
PubMed ID
Title
Journal
Year
11706405
GRB2: a pivotal protein in signal transduction
Lopez-Berestein, G
,
Tari, AM
Semin Oncol
2001
11498013
Internalization of the epidermal growth factor receptor: role in signalling
Sorkin, A
Biochem Soc Trans
2001
Participants
Events
GRB2-1 binds SOS1
(Homo sapiens)
GRB2:SOS1 complex binds to EGF:EGFR complex
(Homo sapiens)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
(Homo sapiens)
Participates
as an event of
Signaling by EGFR (Homo sapiens)
Orthologous Events
GRB2 events in EGFR signaling (Bos taurus)
GRB2 events in EGFR signaling (Caenorhabditis elegans)
GRB2 events in EGFR signaling (Canis familiaris)
GRB2 events in EGFR signaling (Danio rerio)
GRB2 events in EGFR signaling (Drosophila melanogaster)
GRB2 events in EGFR signaling (Gallus gallus)
GRB2 events in EGFR signaling (Mus musculus)
GRB2 events in EGFR signaling (Rattus norvegicus)
GRB2 events in EGFR signaling (Sus scrofa)
GRB2 events in EGFR signaling (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000594
,
BIOMD0000000223
,
BIOMD0000000595
,
BIOMD0000000468
,
BIOMD0000000255
,
BIOMD0000000175
,
BIOMD0000000652
,
BIOMD0000000655
,
BIOMD0000000648
,
BIOMD0000000466
,
BIOMD0000000883
,
BIOMD0000000654
,
BIOMD0000000424
,
BIOMD0000000019
,
BIOMD0000000653
,
BIOMD0000000477
,
BIOMD0000000656
,
BIOMD0000000399
Authored
Castagnoli, L (2006-10-10)
Reviewed
Heldin, CH (2008-02-12)
Created
Jassal, B (2006-05-09)
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