EGFR [plasma membrane]

Stable Identifier
R-HSA-179837
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Epidermal Growth Factor Receptor
EGFR [plasma membrane] icon
Locations in the PathwayBrowser for interactor UniProt:P16615 ATP2A2
External Reference Information
External Reference
Gene Names
EGFR, ERBB, ERBB1, HER1
Chain
signal peptide:1-24, chain:25-1210
Other Identifiers
11725102_at
11725103_s_at
11725104_a_at
11733760_a_at
11738815_at
11742247_a_at
11751983_a_at
1537_at
1565483_PM_at
1565483_at
1565484_PM_x_at
1565484_x_at
17046135
1956
201983_PM_s_at
201983_s_at
201984_PM_s_at
201984_s_at
210984_PM_x_at
210984_x_at
211550_PM_at
211550_at
211607_PM_x_at
211607_x_at
224999_PM_at
224999_at
3002641
3002642
3002729
3002731
3002733
3002738
3002741
3002743
3002747
3002749
3002750
3002751
3002753
3002757
3002760
3002761
3002763
3002767
3002769
3002770
3002771
3002775
3002776
3002778
3002779
3002786
3002798
3002800
3002801
3002802
3002806
3002807
3002808
3002811
3002812
3002813
3002814
3002815
3002816
3002817
3002818
3002819
3002820
3002821
3002822
3002823
3002824
3002825
37327_at
48285_at
65700_at
8132860
A_14_P106592
A_23_P215790
A_33_P3351944
A_33_P3351955
GE59632
GO:0000139
GO:0000165
GO:0000166
GO:0000278
GO:0000902
GO:0001503
GO:0001618
GO:0001892
GO:0001934
GO:0001942
GO:0003677
GO:0003682
GO:0003690
GO:0003824
GO:0004672
GO:0004709
GO:0004713
GO:0004714
GO:0004888
GO:0005006
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005635
GO:0005737
GO:0005768
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0005925
GO:0006260
GO:0006281
GO:0006351
GO:0006355
GO:0006468
GO:0007155
GO:0007165
GO:0007166
GO:0007169
GO:0007173
GO:0007202
GO:0007435
GO:0007611
GO:0008092
GO:0008283
GO:0008284
GO:0008544
GO:0009925
GO:0009986
GO:0010008
GO:0010750
GO:0012501
GO:0014066
GO:0016020
GO:0016301
GO:0016310
GO:0016323
GO:0016740
GO:0018108
GO:0019899
GO:0019900
GO:0019903
GO:0021795
GO:0022008
GO:0023052
GO:0030054
GO:0030139
GO:0030154
GO:0030163
GO:0030235
GO:0030296
GO:0030297
GO:0030307
GO:0030335
GO:0030669
GO:0031410
GO:0031625
GO:0031901
GO:0031965
GO:0032587
GO:0032991
GO:0033138
GO:0033674
GO:0034614
GO:0036211
GO:0038083
GO:0038127
GO:0038134
GO:0042059
GO:0042127
GO:0042177
GO:0042327
GO:0042802
GO:0043066
GO:0043226
GO:0043235
GO:0043406
GO:0045121
GO:0045296
GO:0045737
GO:0045739
GO:0045740
GO:0045893
GO:0045944
GO:0046328
GO:0046718
GO:0046777
GO:0048146
GO:0048408
GO:0048471
GO:0048546
GO:0048856
GO:0048870
GO:0050673
GO:0050679
GO:0050730
GO:0050790
GO:0050877
GO:0050999
GO:0051015
GO:0051117
GO:0051205
GO:0051897
GO:0060089
GO:0060571
GO:0061024
GO:0061029
GO:0070141
GO:0070372
GO:0070374
GO:0070435
GO:0071230
GO:0071276
GO:0071363
GO:0071364
GO:0071392
GO:0072659
GO:0090263
GO:0097489
GO:0097708
GO:0098590
GO:0098609
GO:0098772
GO:0140096
GO:1900020
GO:1900087
GO:1901224
GO:1902895
GO:1903078
GO:1905208
HMNXSV003006702
HMNXSV003057307
Hs.279898.0.S1_3p_at
Hs.77432.0.S1_3p_a_at
Hs2.367845.1.S1_3p_at
Hs2.367845.1.S1_3p_x_at
ILMN_1696521
ILMN_1728858
ILMN_1755535
ILMN_1798975
PH_hs_0004462
PH_hs_0014421
TC07000328.hg
TC07002321.hg
TC07002322.hg
X00588_at
g12002211_3p_at
g1628549_3p_s_at
g4885198_3p_a_at
p26428
Participates
Other forms of this molecule
Inferred To
Cross References
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
5C8K, 4WKQ, 2N5S, 2ITZ, 2ITQ, 6TG1, 2JIT, 4ZAU, 6Z4B, 7LTX, 6LUB, 7TVD, 5XGM, 4RJ8, 5GTY, 7OM4, 4LRM, 2ITW, 5EM8, 5SX5, 5X2C, 5CNO, 2J6M, 7A2A, 5EDQ, 3OP0, 6JX0, 7LFR, 5FEE, 6S8A, 3W2P, 5Y9T, 4TKS, 3P0Y, 4KRM, 5UGC, 1YY9, 5HIB, 7KXZ, 3VRP, 5CAV, 5ZTO, 2JIV, 5CAP, 7VRA, 8D76, 5GMP, 8A2A, 4RIX, 4LI5, 7UKW, 4R3P, 2RGP, 3UG2, 5ZWJ, 5U8L, 3B2U, 5WB7, 3W32, 6TFY, 2ITY, 5JEB, 7K1I, 7JXM, 5XDL, 4HJO, 7SZ0, 5CAQ, 4WD5, 1M17, 6V6O, 5X27, 3VJN, 2ITP, 7SYE, 5LV6, 5HG5, 3W2Q, 3G5V, 6V66, 6WAK, 6JRX, 3LZB, 6VHN, 5EM5, 5FEQ, 4WRG, 2ITV, 6S89, 7ER2, 4KRO, 7T4J, 2M20, 6JXT, 6V5N, 4RJ6, 4UIP, 5HG7, 6WXN, 6JWL, 5UG8, 5UWD, 6D8E, 7SZ7, 7AEM, 5CAL, 4RJ4, 7JXI, 5HIC, 6JX4, 5WB8, 2RF9, 7U9A, 5J9Z, 2EB3, 3GOP, 5HCX, 4RIW, 7OXB, 4ZSE, 2JIU, 3VRR, 5EDR, 3IKA, 4UV7, 4I22, 8A27, 5XDK, 6TFW, 8D73, 5C8M, 1M14, 5GNK, 3NJP, 6S9D, 5J9Y, 7UKV, 2GS7, 1IVO, 1NQL, 5HCY, 3B2V, 2ITO, 5XWD, 6JRK, 7T4I, 7LEN, 5UG9, 5EM6, 5GTZ, 4LQM, 3VJO, 2M0B, 3BEL, 2ITU, 3C09, 5YU9, 7SYD, 5X2A, 4LL0, 5C8N, 4KRP, 3QWQ, 3G5Y, 4I21, 7K1H, 8HGS, 7JXW, 5HG8, 7A6K, 5CAS, 8HGO, 5CAN, 7LGS, 5X2K, 6TG0, 5CZI, 4RIY, 2J5F, 7JXP, 4JQ7, 3W33, 7SZ5, 1XKK, 4I24, 5D41, 7U99, 6P1L, 4R5S, 6S9C, 4I20, 5UGA, 6Z4D, 4RJ7, 7JXL, 6TFV, 4G5J, 2GS6, 6B3S, 7B85, 5CZH, 6JRJ, 3W2R, 6V5P, 7A6I, 5EDP, 3PFV, 5FED, 6TFU, 6JZ0, 7SI1, 5X28, 2RFD, 3BUO, 4I23, 6LUD, 5SX4, 5HG9, 4R3R, 7LG8, 5CAU, 5CAO, 5X26, 3POZ, 4JRV, 5X2F, 4I1Z, 3W2O, 5HCZ, 6WA2, 4RJ5, 6V6K, 8A2D, 2ITX, 1Z9I, 4ZJV, 2J5E, 8HGP, 5CNN, 5EM7, 6P1D, 7VRE, 7JXQ, 4G5P, 5Y25, 7KY0, 8A2B, 7LFS, 2EB2, 1MOX, 3W2S, 7U98, 4KRL, 7JXK, 2ITT, 4JR3, 7A6J, 6DUK, 5XGN, 3UG1, 3GT8, 2RFE, 6S9B, 6VH4, 6VHP, 7SZ1, 6ARU, 2GS2, 2KS1, 7AEI, 5UGB, 2ITN, 3OB2, 6TFZ, 6P8Q, 4JQ8, 6XL4
ZINC - Investigational
ZINC - Metabolites
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (320)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P62993 GRB2  1 0.982 58
 UniProt:P00533 EGFR  20 0.981 29
 UniProt:P29353 SHC1  5 0.976 44
 UniProt:P01133 EGF  5 0.973 29
 UniProt:P22681 CBL  20 0.964 26
 UniProt:P04626 ERBB2  20 0.954 25
 UniProt:P40763 STAT3  12 0.919 15
 UniProt:P21860 ERBB3      0.91 13
 UniProt:P12931 SRC  6 0.9 9
 UniProt:P18031 PTPN1  2 0.898 9
 UniProt:P08238 HSP90AB1  6 0.89 10
 UniProt:Q9UJM3 ERRFI      0.866 14
 UniProt:P27348 YWHAQ  1 0.854 7
 UniProt:P19174 PLCG1  6 0.85 6
 UniProt:P31947 SFN  1 0.833 9
 UniProt:P62158 CALM      0.828 6
 UniProt:Q96CW1 AP2M1  6 0.828 8
 UniProt:P16333 NCK1  2 0.823 6
 UniProt:Q06124 PTPN11  4 0.821 8
 UniProt:P07948 LYN  7 0.82 7
 UniProt:P15941 MUC1  19 0.819 6
 UniProt:Q03135 CAV1  5 0.813 7
 UniProt:O00750 PIK3C2B  1 0.811 10
 UniProt:P27986 PIK3R1  16 0.81 7
 UniProt:Q9UBN7 HDAC6  4 0.809 12
 UniProt:Q05209 PTPN12  2 0.807 5
 UniProt:P11142 HSPA8  10 0.803 7
 UniProt:P20417  2 0.802 11
 UniProt:P08581 MET  7 0.8 8
 UniProt:P08107 HSP71      0.799 6
 UniProt:Q92625 ANS1A      0.793 7
 UniProt:P16885 PLCG2  8 0.793 6
 UniProt:Q16543 CDC37  1 0.786 13
 UniProt:P04406 GAPDH  1 0.785 7
 UniProt:P10599 TXN  4 0.785 5
 UniProt:P01135 TGFA  5 0.779 4
 UniProt:P07900 HSP90AA1  8 0.778 7
 UniProt:P42224 STAT1  7 0.774 7
 UniProt:Q9NRF2 SH2B1  1 0.773 4
 UniProt:P04083 ANXA1  2 0.772 5
 UniProt:P63104 YWHAZ  2 0.772 6
 UniProt:Q92569 PIK3R3  2 0.76 7
 UniProt:O00459 PIK3R2  2 0.76 5
 UniProt:P46109 CRKL  2 0.749 5
 UniProt:Q71U36 TUBA1A  9 0.745 4
 UniProt:P38646 HSPA9  6 0.745 5
 UniProt:Q05397 PTK2  11 0.745 7
 UniProt:O60716 CTNND1  1 0.745 5
 UniProt:P26447 S10A4      0.743 6
 UniProt:Q96JA1 LRIG1  2 0.743 6
 UniProt:Q92870 APBB2      0.737 7
 UniProt:Q9NSE2 CISH  1 0.737 4
 UniProt:Q13480 GAB1  4 0.735 5
 UniProt:P12830 CDH1  8 0.735 4
 UniProt:Q9UQB8 BAIAP2  1 0.735 4
 UniProt:Q13322 GRB10  2 0.729 4
 UniProt:Q9UNE7 STUB1  1 0.721 4
 UniProt:Q12929 EPS8  1 0.713 4
 UniProt:Q9P0L0 VAPA  4 0.713 4
 UniProt:Q96B97 SH3KBP1  3 0.695 4
 UniProt:Q13387 JIP2      0.692 5
 UniProt:P46108 CRK  1 0.692 4
 UniProt:Q13239 SLA  1 0.692 3
 UniProt:P23467 PTPRB  3 0.692 3
 UniProt:P43403 ZAP70  3 0.692 3
 UniProt:P00519 ABL1  5 0.692 3
 UniProt:P51451 BLK  2 0.692 3
 UniProt:P42684 ABL2  1 0.692 9
 UniProt:Q14318 FKBP8  2 0.683 4
 UniProt:Q68CZ2 TNS3  1 0.683 5
 UniProt:P16234 PDGFRA  20 0.683 4
 UniProt:O75368 SH3L1      0.681 3
 UniProt:O60603 TLR2  3 0.681 3
 UniProt:P41240 CSK  2 0.681 3
 UniProt:Q99962 SH3GL2  4 0.681 4
 UniProt:Q8WUM4 PDCD6IP  1 0.681 4
 UniProt:P35221 CTNNA1  2 0.68 5
 UniProt:Q9UKV8 AGO2  2 0.679 11
 UniProt:O95782 AP2A1  5 0.671 6
 UniProt:Q9UQC2 GAB2  5 0.669 3
 UniProt:P34932 HSPA4  2 0.668 3
 UniProt:P23528 CFL1  3 0.668 3
 UniProt:Q09666 AHNK      0.667 4
 UniProt:P51636 CAV2  2 0.667 3
 UniProt:P06493 CDK1  11 0.667 3
 UniProt:Q9NZM3 ITSN2  1 0.653 3
 UniProt:P14923 JUP  6 0.653 3
 UniProt:P15311 EZR  3 0.653 3
 UniProt:Q15750 TAB1  6 0.653 3
 UniProt:P08631 HCK  2 0.653 3
 UniProt:Q10567 AP1B1  5 0.649 4
 UniProt:Q8NBJ4 GOLM1  2 0.644 13
 UniProt:P08195 SLC3A2  1 0.643 5
 UniProt:P16615 ATP2A2  2 0.643 3
 UniProt:P60520 GABARAPL2  3 0.635 3
 UniProt:P04150 NR3C1  3 0.635 3
 UniProt:Q9Y2H9 MAST1      0.635 3
 UniProt:P49069 CAMLG  1 0.635 3
 UniProt:Q6S5L8 SHC4      0.635 3
 UniProt:Q8WUI4 HDAC7  1 0.635 3
 UniProt:Q02952 AKAP12  1 0.635 3
 UniProt:Q9BRG2 SH23A      0.635 3
 UniProt:P09936 UCHL1  1 0.635 3
 UniProt:O43561 LAT  3 0.635 3
 UniProt:P09769 FGR  3 0.635 3
 UniProt:Q12933 TRAF2  5 0.635 4
 UniProt:P31948 STIP1  1 0.635 3
 UniProt:O75791 GRAP2  1 0.635 3
 UniProt:P17252 PRKCA  8 0.635 3
 UniProt:P42229 STAT5A  6 0.635 4
 UniProt:Q9Y2R2 PTPN22  1 0.635 3
 UniProt:P18433 PTPRA  1 0.635 3
 UniProt:Q13094 LCP2  2 0.635 3
 UniProt:Q14247 CTTN  2 0.635 4
 UniProt:Q14457 BECN1  3 0.628 7
 UniProt:P46940 IQGAP1  3 0.626 4
 UniProt:Q12852 M3K12      0.621 3
 UniProt:Q6UW88 EPGN  2 0.618 3
 UniProt:O14944 EREG  2 0.618 3
 UniProt:P04792 HSPB1  3 0.615 3
 UniProt:Q99075 HBEGF  8 0.609 3
 UniProt:Q9UJ41 RABGEF1  2 0.599 4
 UniProt:Q86VI4 LAP4B      0.599 10
 UniProt:Q8TF42 UBS3B      0.597 6
 UniProt:P60033 CD81  1 0.597 6
 UniProt:P08575 PTPRC  2 0.592 2
 UniProt:P14174 MIF  3 0.591 3
 UniProt:O75886 STAM2  2 0.583 3
 UniProt:P07355 ANXA2  4 0.583 4
 UniProt:P29353-7 SHC1      0.581 4
 UniProt:O14965 AURKA  6 0.581 4
 UniProt:Q01973 ROR1  2 0.576 8
 UniProt:P23470 PTPRG      0.573 3
 UniProt:Q9Y6R0 NUMBL      0.571 2
 UniProt:Q9UKG1 APPL1  1 0.571 3
 UniProt:P49757 NUMB  1 0.571 2
 UniProt:P07992 ERCC1  2 0.571 21
 IntAct:EBI-11820565 HSPA1A      0.569 3
 UniProt:P63010 AP2B1  4 0.569 5
 UniProt:P53680 AP2S1  4 0.569 3
 UniProt:O94973 AP2A2  6 0.569 4
 UniProt:Q9UBS4 DNAJB11  1 0.569 3
 UniProt:Q92622 RUBIC      0.564 3
 UniProt:Q15303 ERBB4      0.564 3
 UniProt:P62994 Grb2  3 0.564 5
 UniProt:Q13451 FKBP5  2 0.564 2
 UniProt:P07947 YES1  2 0.564 3
 UniProt:Q07889 SOS1  3 0.564 2
 UniProt:Q8IZV2 CKLF8      0.556 3
 UniProt:O75674 TM1L1      0.556 6
 UniProt:P05107 ITGB2  4 0.553 2
 UniProt:Q99963 SH3GL3  1 0.553 2
 UniProt:P40925 MDH1  1 0.553 2
 UniProt:Q99608 NDN  1 0.553 2
 UniProt:O00170 AIP  2 0.553 2
 UniProt:Q9H299 SH3L3      0.553 2
 UniProt:Q8N111 CEND      0.553 2
 UniProt:Q59GR8 Q59GR8      0.553 2
 UniProt:Q14204 DYNC1H1  3 0.553 2
 UniProt:P16930 FAH  1 0.553 2
 UniProt:Q59G22 Q59G22      0.553 2
 UniProt:Q13491 GPM6B      0.553 2
 UniProt:A4FU49 SH321      0.553 2
 UniProt:P60174 TPI1  1 0.553 2
 UniProt:O95433 AHSA1      0.553 2
 UniProt:Q7L273 KCTD9      0.553 2
 UniProt:Q4KWH8 PLCH1  1 0.553 2
 UniProt:O15511 ARPC5  4 0.553 2
 UniProt:P55036 PSMD4  2 0.553 2
 UniProt:O14818 PSMA7  2 0.553 2
 UniProt:Q99759 MAP3K3  1 0.553 2
 UniProt:P31321 PRKAR1B  2 0.553 2
 UniProt:P19438 TNFRSF1A  2 0.553 2
 UniProt:P06132 UROD  1 0.553 2
 UniProt:P04075 ALDOA  6 0.553 2
 UniProt:O00401 WASL  4 0.553 2
 UniProt:Q8TDI0 CHD5      0.553 2
 UniProt:Q8N2Y8 RUSC2      0.553 2
 UniProt:Q13561 DCTN2  1 0.553 2
 UniProt:Q53GZ6 Q53GZ6      0.553 2
 UniProt:P17600 SYN1  2 0.553 2
 UniProt:P31939 ATIC  5 0.553 2
 UniProt:P54368 OAZ1  1 0.553 2
 UniProt:Q9UPY6 WASF3  3 0.553 2
 UniProt:Q9NNZ3 DNJC4      0.553 2
 UniProt:P17174 GOT1  1 0.553 2
 UniProt:Q9Y5X1 SNX9  3 0.553 2
 UniProt:Q14050 COL9A3  20 0.553 2
 UniProt:O94992 HEXI1      0.553 2
 UniProt:Q96AD5 PNPLA2  3 0.553 2
 UniProt:Q9Y3A3 PHOCN      0.553 2
 UniProt:O94875 SRBS2      0.553 2
 UniProt:Q15819 UBE2V2  2 0.553 2
 UniProt:P45984 MAPK9  3 0.553 2
 UniProt:Q6UWJ1 TMCO3      0.553 2
 UniProt:Q99784 NOE1      0.553 2
 UniProt:Q92918 M4K1      0.553 2
 UniProt:Q07890 SOS2  1 0.553 2
 UniProt:P49798 RGS4  1 0.553 2
 UniProt:O75095 MEGF6      0.553 2
 UniProt:Q15120 PDK3  1 0.553 2
 UniProt:O43707 ACTN4  3 0.553 2
 UniProt:Q8N5H7 SH2D3      0.553 2
 UniProt:Q02297 NRG1  1 0.553 2
 UniProt:P62330 ARF6  2 0.553 2
 UniProt:Q15005 SPCS2  1 0.553 2
 UniProt:Q92733 PRCC  1 0.553 2
 UniProt:Q59EJ3 Q59EJ3      0.553 2
 UniProt:P43243 MATR3      0.553 2
 UniProt:P49908 SELENOP  2 0.553 2
 UniProt:Q8TDB4 HUMMR      0.553 2
 UniProt:Q02156 PRKCE  2 0.553 2
 UniProt:Q9Y237 PIN4      0.553 2
 UniProt:O14544 SOCS6  1 0.553 2
 UniProt:P60880 SNAP25  7 0.553 2
 UniProt:Q02790 FKBP4  3 0.553 2
 UniProt:Q08881 ITK  3 0.553 2
 UniProt:Q9H6Q3 SLA2  1 0.553 2
 UniProt:Q16620 NTRK2  6 0.553 2
 UniProt:Q99952 PTPN18  2 0.553 2
 UniProt:P14625 HSP90B1  4 0.553 2
 UniProt:P05067 APP  20 0.553 2
 UniProt:Q02246 CNTN2  1 0.553 2
 UniProt:P31749 AKT1  13 0.553 2
 UniProt:P21291 CSRP1  1 0.553 2
 UniProt:O43639 NCK2  1 0.553 2
 UniProt:P32121 ARRB2  2 0.553 2
 UniProt:Q14155 ARHGEF7  1 0.553 2
 UniProt:P10636 MAPT  3 0.553 2
 UniProt:P53041 PPP5C  2 0.553 2
 UniProt:P49407 ARRB1  5 0.553 2
 UniProt:P52306 RAP1GDS1  1 0.553 2
 UniProt:P42685 FRK  4 0.553 2
 UniProt:P30307 CDC25C  8 0.553 2
 UniProt:P31946 YWHAB  1 0.553 2
 UniProt:Q9Y6K9 IKBKG  12 0.553 2
 UniProt:P45983 MAPK8  3 0.553 2
 UniProt:P04049 RAF1  20 0.553 2
 UniProt:Q9UGK3 STAP2  2 0.553 2
 UniProt:P11309 PIM1  1 0.553 2
 UniProt:Q06830 PRDX1  3 0.553 2
 UniProt:P52630 STAT2  4 0.553 2
 UniProt:P07949 RET