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EGF:EGFR [plasma membrane]
Stable Identifier
R-HSA-179847
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ERBB2 in Cancer (Homo sapiens)
Signaling by ERBB2 ECD mutants (Homo sapiens)
ERBB2 ECD mutants heterodimerize with EGFR (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
ERBB2 ECD mutants:EGF:EGFR [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate (Homo sapiens)
ERBB2 ECD mutants:EGF:EGFR [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
Signaling by ERBB2 KD Mutants (Homo sapiens)
ERBB2 KD mutants heterodimerize (Homo sapiens)
Heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
Ligand-Activated (EGFR,ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)
Heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
ERBB2 KD mutants:Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
Signaling by ERBB2 TMD/JMD mutants (Homo sapiens)
ERBB2 TMD/JMD heterodimers trans-autophosphorylate (Homo sapiens)
ERBB2 TMD/JMD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
ERBB2 TMD/JMD mutants hetrodimerize (Homo sapiens)
ERBB2 TMD/JMD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Homo sapiens)
ERBB2 heterodimers [plasma membrane] (Homo sapiens)
EGF:EGFR:ERBB2 [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR/ERBB3/ERBB4 [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
SRC family kinases phosphorylate ERBB2 (Homo sapiens)
ERBB2 heterodimers [plasma membrane] (Homo sapiens)
EGF:EGFR:ERBB2 [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
EGF:EGFR:p-Y877-ERBB2 [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
Trans-autophosphorylation of ERBB2 heterodimers (Homo sapiens)
ERBB2 heterodimers [plasma membrane] (Homo sapiens)
EGF:EGFR:ERBB2 [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Homo sapiens)
p-Y877-ERBB2 heterodimers [plasma membrane] (Homo sapiens)
EGF:EGFR:p-Y877-ERBB2 [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
Signaling by ERBB4 (Homo sapiens)
ERBB4 forms heterodimers with EGFR (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
ERBB4:EGFR heterodimer [plasma membrane] (Homo sapiens)
EGF:EGFR [plasma membrane] (Homo sapiens)
Participants
components
EGF [extracellular region]
(Homo sapiens)
EGFR [plasma membrane]
(Homo sapiens)
Participates
as an input of
ERBB2 ECD mutants heterodimerize with EGFR (Homo sapiens)
ERBB4 forms heterodimers with EGFR (Homo sapiens)
as a component of
ERBB2 ECD mutants:EGF:EGFR [plasma membrane] (Homo sapiens)
ERBB4:EGFR heterodimer [plasma membrane] (Homo sapiens)
EGF:EGFR:ERBB2 [plasma membrane] (Homo sapiens)
EGF:EGFR:p-Y877-ERBB2 [plasma membrane] (Homo sapiens)
as a member of
Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
Ligand-Activated EGFR/ERBB3/ERBB4 [plasma membrane] (Homo sapiens)
as a candidate of
Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
Inferred To
EGFR:EGF-like ligands [plasma membrane]
(Caenorhabditis elegans)
EGFR:EGF-like ligands [plasma membrane]
(Drosophila melanogaster)
EGF:EGFR [plasma membrane]
(Canis familiaris)
EGF:EGFR [plasma membrane]
(Gallus gallus)
EGF:EGFR [plasma membrane]
(Mus musculus)
EGF:EGFR [plasma membrane]
(Rattus norvegicus)
EGF:EGFR [plasma membrane]
(Sus scrofa)
EGF:EGFR [plasma membrane]
(Xenopus tropicalis)
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