Reactome | CDK5 [cytosol]

CDK5 [cytosol]

Stable Identifier

R-HSA-180064

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - CRMPs in Sema3A signaling (Homo sapiens)
        
        Recruitment and activation of Cdk5 (Homo sapiens)
        
        CDK5:p35 [plasma membrane] (Homo sapiens)
        
        CDK5 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q00535 CDK5

Gene Names

CDK5, CDKN5, PSSALRE

Chain

chain:1-292

Reference Genes

BioGPS Gene:1020 CDK5

COSMIC (genes):CDK5 CDK5

CTD Gene:1020 CDK5

dbSNP Gene:1020 CDK5

ENSEMBL:ENSG00000164885.13 CDK5

HGNC:1774 CDK5

KEGG Gene (Homo sapiens):1020 CDK5

Monarch:1020 CDK5

NCBI Gene:1020 CDK5

OMIM:123831 CDK5

UCSC:Q00535 CDK5

Reference Transcript

Other Identifiers

0005860309

1020

11751815_a_at

11754938_a_at

1206_at

17064360

204247_PM_s_at

204247_s_at

3079314

3079315

3079316

3079317

3079319

3079320

3079321

3079322

3079323

3079324

3079325

3079326

3079328

3079329

3079330

3113884

40549_at

8143850

A_23_P8400

GE57557

GE86263

GO:0000083

GO:0000166

GO:0000226

GO:0000278

GO:0000307

GO:0001764

GO:0001934

GO:0001963

GO:0002039

GO:0004672

GO:0004674

GO:0004693

GO:0005176

GO:0005215

GO:0005515

GO:0005524

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0006886

GO:0006887

GO:0006913

GO:0006914

GO:0006915

GO:0007005

GO:0007010

GO:0007049

GO:0007155

GO:0007160

GO:0007268

GO:0007399

GO:0007409

GO:0007416

GO:0007519

GO:0008045

GO:0008092

GO:0008306

GO:0008542

GO:0009611

GO:0012501

GO:0014044

GO:0014069

GO:0016020

GO:0016079

GO:0016192

GO:0016241

GO:0016301

GO:0016310

GO:0016477

GO:0016533

GO:0016740

GO:0018105

GO:0018107

GO:0019233

GO:0019901

GO:0021537

GO:0021549

GO:0021695

GO:0021697

GO:0021766

GO:0021819

GO:0021954

GO:0021987

GO:0022038

GO:0023052

GO:0030027

GO:0030054

GO:0030154

GO:0030175

GO:0030182

GO:0030334

GO:0030424

GO:0030425

GO:0030426

GO:0030517

GO:0030549

GO:0030866

GO:0030900

GO:0031175

GO:0031397

GO:0031594

GO:0031914

GO:0032092

GO:0032801

GO:0032991

GO:0034330

GO:0034352

GO:0035173

GO:0035249

GO:0035418

GO:0036211

GO:0042220

GO:0042501

GO:0042981

GO:0042995

GO:0043005

GO:0043025

GO:0043113

GO:0043125

GO:0043204

GO:0043226

GO:0043525

GO:0045055

GO:0045202

GO:0045786

GO:0045860

GO:0045861

GO:0045892

GO:0045956

GO:0046777

GO:0046826

GO:0046875

GO:0048148

GO:0048156

GO:0048167

GO:0048488

GO:0048489

GO:0048511

GO:0048675

GO:0048709

GO:0048812

GO:0048813

GO:0048856

GO:0048870

GO:0050321

GO:0050877

GO:0051301

GO:0051402

GO:0051649

GO:0051726

GO:0051879

GO:0051966

GO:0055065

GO:0055085

GO:0060078

GO:0060079

GO:0061001

GO:0070509

GO:0072659

GO:0090314

GO:0098685

GO:0098772

GO:0098793

GO:0098794

GO:0098883

GO:0098978

GO:0099533

GO:0099635

GO:0099703

GO:0106310

GO:0140096

GO:1901215

GO:1901216

GO:1901387

GO:1903076

GO:1903421

GO:1904646

GO:2000251

HMNXSV003006567

ILMN_1754375

ILMN_1781987

PH_hs_0029292

PH_hs_0031953

TC07002027.hg

X66364_at

g4826674_3p_at

Participates

as a component of

as an input of

as an output of

CDK5 gene expression is stimulated by NPAS4 (Homo sapiens)

Other forms of this molecule

CDK5 [nucleoplasm]

p-Y15,S159-CDK5 [nucleoplasm]

p-Y15-CDK5 [cytosol]

Inferred To

Cdk5 [cytosol] (Mus musculus)

Cdk5 [cytosol] (Rattus norvegicus)

CDK5 [cytosol] (Bos taurus)

CDK5 [cytosol] (Canis familiaris)

CDK5 [cytosol] (Danio rerio)

CDK5 [cytosol] (Gallus gallus)

CDK5 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001157882.1, NP_004926.1

ZINC - World Drugs

CDK5_HUMAN

Guide to Pharmacology - Targets

1977

OpenTargets

ENSG00000164885

ZINC - FDA approved

CDK5_HUMAN

ZINC - Substances

CDK5_HUMAN

ZINC target

Q00535

ZINC - Biogenic

CDK5_HUMAN

PRO

Q00535

PDB

4AU8, 1UNL, 3O0G, 7VDP, 7VDS, 7VDQ, 1UNH, 1UNG, 1H4L, 7VDR

ZINC - Investigational

CDK5_HUMAN

ZINC - Metabolites

CDK5_HUMAN

HPA

ENSG00000164885-CDK5

GeneCards

Q00535

Ensembl

ENSG00000164885, ENST00000485972, ENSP00000297518, ENSP00000419782, ENST00000297518

Pharos - Targets

Q00535

Orphanet

26306

ZINC - Predictions - Purchasable

CDK5_HUMAN

HMDB Protein

HMDBP01398

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30279 CCND2	2	CCND2 [cytosol] (R-HSA-68340) CCND2 [nucleoplasm] (R-HSA-113827)	0.956	16
UniProt:Q15078 CDK5R1	4	MyrG-CDK5R1(2-307) [plasma membrane] (R-HSA-421083) CDK5R1(99-307) [nucleoplasm] (R-HSA-6805262) CDK5R1(99-307) [cytosol] (R-HSA-8863415) MyrG-CDK5R1(2-98) [plasma membrane] (R-HSA-8863400)	0.935	13
UniProt:P46527 CDKN1B	8	p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.935	11
UniProt:Q8TDN4 CABLES1	2	CABLES1 [cytosol] (R-HSA-1013859) CABLES1 [nucleoplasm] (R-HSA-1013870)	0.848	7
UniProt:P30281 CCND3	2	CCND3 [nucleoplasm] (R-HSA-113835) CCND3 [cytosol] (R-HSA-68333)	0.845	10
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.793	5
UniProt:Q86YS7 C2CD5	2	C2CD5 [plasma membrane] (R-HSA-5216175) p-S197-C2CD5 [plasma membrane] (R-HSA-5260194)	0.788	5
UniProt:P14635 CCNB1	4	CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049) CCNB1 [cytosol] (R-HSA-157451)	0.788	5
UniProt:Q12767 TMM94			0.725	4
UniProt:Q9BTV7 CABLES2	1	CABLES2 [cytosol] (R-HSA-1013845)	0.725	4
UniProt:O43427 FIBP			0.725	4
UniProt:Q14094 CCNI			0.666	4
UniProt:A6NLX3 SPDE4			0.666	4
UniProt:Q00526 CDK3			0.643	3
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.643	3
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.643	3
UniProt:P50990 CCT8	5	CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [cytosol] (R-HSA-390449)	0.643	3
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.643	3
UniProt:P61158 ACTR3	1	ACTR3 [cytosol] (R-HSA-200811)	0.556	3
UniProt:O60260-5 PRKN			0.556	3
UniProt:Q5MJ70 SPDYA			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P23560-2 BDNF			0.556	3
UniProt:Q9UJC3 HOOK1			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q9Y6R0 NUMBL			0.556	3
UniProt:P62937 PPIA	5	PPIA [extracellular exosome] (R-HSA-6801538) PPIA [secretory granule lumen] (R-HSA-6801400) PPIA [extracellular region] (R-HSA-173646) PPIA [ficolin-1-rich granule lumen] (R-HSA-6801391) PPIA [cytosol] (R-HSA-173123)	0.556	3
UniProt:P20226 TBP	1	TBP [nucleoplasm] (R-HSA-83718)	0.556	3
UniProt:P78371 CCT2	3	CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [extracellular region] (R-HSA-6806220) CCT2 [cytosol] (R-HSA-390464)	0.527	2
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.527	2
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	2
UniProt:Q9C098 DCLK3			0.527	2
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.527	2
UniProt:P20248 CCNA2	3	PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [cytosol] (R-HSA-157444) CCNA2 [nucleoplasm] (R-HSA-68905)	0.527	2
UniProt:P37231-2 PPARG			0.508	2
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.499	2

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