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CDK5 [cytosol]
Stable Identifier
R-HSA-180064
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser for interactor UniProt:P50991 CCT4
Expand all
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
CDK5 binds p25 (Homo sapiens)
CDK5 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by NPAS4 (Homo sapiens)
NPAS4 regulates expression of target genes (Homo sapiens)
CDK5 gene expression is stimulated by NPAS4 (Homo sapiens)
CDK5 [cytosol] (Homo sapiens)
MyrG-CDK5R1 binds CDK5 (Homo sapiens)
CDK5 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Cables link CDK5 and ABL1 (Homo sapiens)
CDK5 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
CDK5 phosphorylates DARPP-32 on Thr75 (Homo sapiens)
CDK5 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
NGF-stimulated transcription (Homo sapiens)
MyrG-CDK5R1,2 bind CDK5 (Homo sapiens)
CDK5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q00535 CDK5
Gene Names
CDK5, CDKN5, PSSALRE
Chain
chain:1-292
Reference Genes
BioGPS Gene:1020 CDK5
COSMIC (genes):CDK5 CDK5
CTD Gene:1020 CDK5
dbSNP Gene:1020 CDK5
ENSEMBL:ENSG00000164885 CDK5
ENSEMBL_homo_sapiens_GENE:ENSG00000164885.13 CDK5
HGNC:1774 CDK5
KEGG Gene (Homo sapiens):1020 CDK5
Monarch:1020 CDK5
NCBI Gene:1020 CDK5
OMIM:123831 CDK5
UCSC:Q00535 CDK5
Reference Transcript
RefSeq:NM_001164410.2 CDK5
RefSeq:NM_004935.3 CDK5
Other Identifiers
1020
11751815_a_at
11754938_a_at
1206_at
17064360
204247_PM_s_at
204247_s_at
3079312
3079314
3079315
3079316
3079317
3079319
3079320
3079321
3079322
3079323
3079324
3079325
3079326
3079328
3079329
3079330
3113884
40549_at
8143850
A_23_P8400
GE57557
GE86263
GO:0000166
GO:0000226
GO:0000307
GO:0001764
GO:0001963
GO:0002039
GO:0003824
GO:0004672
GO:0004674
GO:0004693
GO:0005176
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006886
GO:0006913
GO:0006914
GO:0006915
GO:0007010
GO:0007049
GO:0007155
GO:0007160
GO:0007268
GO:0007399
GO:0007409
GO:0007416
GO:0007519
GO:0008045
GO:0008092
GO:0008306
GO:0008542
GO:0012501
GO:0014044
GO:0014069
GO:0016020
GO:0016079
GO:0016192
GO:0016241
GO:0016301
GO:0016310
GO:0016477
GO:0016533
GO:0016740
GO:0018105
GO:0018107
GO:0019233
GO:0021537
GO:0021549
GO:0021695
GO:0021697
GO:0021766
GO:0021819
GO:0021954
GO:0021987
GO:0022038
GO:0023052
GO:0030027
GO:0030054
GO:0030154
GO:0030175
GO:0030182
GO:0030334
GO:0030424
GO:0030425
GO:0030426
GO:0030517
GO:0030549
GO:0030900
GO:0031175
GO:0031397
GO:0031594
GO:0031914
GO:0032801
GO:0034330
GO:0035249
GO:0035418
GO:0036211
GO:0042220
GO:0042981
GO:0042995
GO:0043005
GO:0043025
GO:0043113
GO:0043125
GO:0043204
GO:0043226
GO:0043525
GO:0045202
GO:0045786
GO:0045861
GO:0045892
GO:0045956
GO:0046826
GO:0048148
GO:0048156
GO:0048167
GO:0048488
GO:0048489
GO:0048511
GO:0048675
GO:0048709
GO:0048813
GO:0048856
GO:0048870
GO:0050321
GO:0050877
GO:0051301
GO:0051402
GO:0051649
GO:0051726
GO:0051879
GO:0051966
GO:0060078
GO:0060079
GO:0061001
GO:0070509
GO:0072659
GO:0090314
GO:0098772
GO:0098793
GO:0106310
GO:0140096
GO:1903076
GO:1903421
GO:1904646
HMNXSV003006567
ILMN_1781987
PH_hs_0029292
PH_hs_0031953
TC07002027.hg
X66364_at
g4826674_3p_at
Participates
as a component of
CDK5:CABLES:ABL [cytosol] (Homo sapiens)
CDK5:p25 [cytosol] (Homo sapiens)
CDK5:MyrG-CDK5R1,2 [plasma membrane] (Homo sapiens)
CDK5:p35 [plasma membrane] (Homo sapiens)
as an input of
Cables link CDK5 and ABL1 (Homo sapiens)
CDK5 binds p25 (Homo sapiens)
MyrG-CDK5R1 binds CDK5 (Homo sapiens)
Ntrk2 phosohorylates CDK5 (Homo sapiens)
MyrG-CDK5R1,2 bind CDK5 (Homo sapiens)
as an output of
CDK5 gene expression is stimulated by NPAS4 (Homo sapiens)
Other forms of this molecule
CDK5 [nucleoplasm]
p-Y15,S159-CDK5 [nucleoplasm]
p-Y15-CDK5 [cytosol]
Inferred To
Cdk5 [cytosol]
(Mus musculus)
Cdk5 [cytosol]
(Rattus norvegicus)
CDK5 [cytosol]
(Bos taurus)
CDK5 [cytosol]
(Canis familiaris)
CDK5 [cytosol]
(Gallus gallus)
CDK5 [cytosol]
(Sus scrofa)
CDK5 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001157882.1
,
NP_004926.1
ZINC - World Drugs
CDK5_HUMAN
Guide to Pharmacology - Targets
1977
OpenTargets
ENSG00000164885
ZINC - FDA approved
CDK5_HUMAN
ZINC - Substances
CDK5_HUMAN
ZINC - Biogenic
CDK5_HUMAN
ZINC target
Q00535
PRO
Q00535
PDB
1UNL
,
7VDS
,
7VDQ
,
1UNG
,
3O0G
,
1H4L
,
4AU8
,
7VDR
,
7VDP
,
1UNH
ZINC - Investigational
CDK5_HUMAN
ZINC - Metabolites
CDK5_HUMAN
GeneCards
Q00535
HPA
ENSG00000164885-CDK5
Ensembl
ENSP00000419782
,
ENSP00000297518
,
ENST00000485972
,
ENST00000297518
,
ENSG00000164885
Pharos - Targets
Q00535
ZINC - Predictions - Purchasable
CDK5_HUMAN
HMDB Protein
HMDBP01398
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P30279 CCND2
2
CCND2 [cytosol]
(R-HSA-68340)
CCND2 [nucleoplasm]
(R-HSA-113827)
0.959
18
UniProt:Q15078 CDK5R1
4
MyrG-CDK5R1(2-307) [plasma membrane]
(R-HSA-421083)
CDK5R1(99-307) [nucleoplasm]
(R-HSA-6805262)
CDK5R1(99-307) [cytosol]
(R-HSA-8863415)
MyrG-CDK5R1(2-98) [plasma membrane]
(R-HSA-8863400)
0.94
15
UniProt:P46527 CDKN1B
8
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
CDKN1B [cytosol]
(R-HSA-198622)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
0.94
14
UniProt:Q8TDN4 CABLES1
2
CABLES1 [cytosol]
(R-HSA-1013859)
CABLES1 [nucleoplasm]
(R-HSA-1013870)
0.886
8
UniProt:P14635 CCNB1
4
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.886
8
UniProt:P30281 CCND3
2
CCND3 [cytosol]
(R-HSA-68333)
CCND3 [nucleoplasm]
(R-HSA-113835)
0.882
12
UniProt:P38936 CDKN1A
5
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
CDKN1A [cytosol]
(R-HSA-182512)
CDKN1A [nucleoplasm]
(R-HSA-182585)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
0.839
7
UniProt:Q86YS7 C2CD5
2
p-S197-C2CD5 [plasma membrane]
(R-HSA-5260194)
C2CD5 [plasma membrane]
(R-HSA-5216175)
0.837
7
UniProt:O43427 FIBP
0.788
8
UniProt:Q14094 CCNI
0.75
6
UniProt:Q00526 CDK3
0.725
5
UniProt:Q12767 ERMA
0.725
4
UniProt:Q9BTV7 CABLES2
1
CABLES2 [cytosol]
(R-HSA-1013845)
0.725
4
UniProt:A6NLX3 SPDE4
0.666
4
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.643
3
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.643
3
UniProt:P50990 CCT8
5
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [cytosol]
(R-HSA-390449)
0.643
3
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.643
3
UniProt:P24385 CCND1
4
CCND1 [nucleoplasm]
(R-HSA-113832)
CCND1 [cytosol]
(R-HSA-68328)
p-T286-CCND1 [nucleoplasm]
(R-HSA-75811)
p-T286-CCND1 [cytosol]
(R-HSA-75813)
0.643
4
UniProt:P20248 CCNA2
3
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [cytosol]
(R-HSA-157444)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.643
4
UniProt:P61158 ACTR3
1
ACTR3 [cytosol]
(R-HSA-200811)
0.556
3
UniProt:O60260-5 PRKN
0.556
3
UniProt:P20226 TBP
1
TBP [nucleoplasm]
(R-HSA-83718)
0.556
3
UniProt:Q5MJ70 SPDYA
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P23560-2 BDNF
0.556
3
UniProt:Q9UJC3 HOOK1
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q9Y6R0 NUMBL
0.556
3
UniProt:P62937 PPIA
5
PPIA [extracellular exosome]
(R-HSA-6801538)
PPIA [secretory granule lumen]
(R-HSA-6801400)
PPIA [extracellular region]
(R-HSA-173646)
PPIA [ficolin-1-rich granule lumen]
(R-HSA-6801391)
PPIA [cytosol]
(R-HSA-173123)
0.556
3
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.547
2
UniProt:P78371 CCT2
3
CCT2 [extracellular region]
(R-HSA-6806220)
CCT2 [azurophil granule lumen]
(R-HSA-6799356)
CCT2 [cytosol]
(R-HSA-390464)
0.527
2
UniProt:Q9BV87 CNPD1
0.527
3
UniProt:P24864 CCNE1
3
CCNE1 [nucleoplasm]
(R-HSA-68363)
CCNE1 [cytosol]
(R-HSA-157443)
Unfolded CCNE1 [cytosol]
(R-HSA-6813836)
0.527
2
UniProt:Q6ZMN8 CCNI2
0.527
2
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.527
2
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.527
2
UniProt:Q9C098 DCLK3
0.527
2
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:Q8IZL9 CDK20
0.527
2
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.527
2
UniProt:P37231-2 PPARG
1
PPARG1 [nucleoplasm]
(R-HSA-9841933)
0.508
2
UniProt:P09936 UCHL1
1
UCHL1 [cytosol]
(R-HSA-5660679)
0.499
2
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