DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function

Stable Identifier
R-HSA-180073
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

DARPP-32 is converted into an inhibitor of protein kinase A (PKA) when phosphorylated at threonine 75 by cyclin-dependent kinase 5 (Cdk5) in brain cells.

Literature References
PubMed ID Title Journal Year
10604473 Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

Bibb, JA, Snyder, GL, Nishi, A, Yan, Z, Meijer, L, Fienberg, AA, Tsai, LH, Kwon, YT, Girault, JA, Czernik, AJ, Huganir, RL, Hemmings HC, Jr, Nairn, AC, Greengard, P

Nature 1999
Participants
Participates
Catalyst Activity

cAMP-dependent protein kinase inhibitor activity of p-T75-DARPP32s [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!