GAB1 signalosome

Stable Identifier
R-HSA-180292
DOI
10.3180/REACT_12578.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GAB1 signalosome
Click the image above or here to open this pathway in the Pathway Browser
GAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also known as PI3Kp85), which subsequently recruits PIK3 catalytic subunit PIK3CA (also known as PI3Kp110). PIK3, in complex with EGFR, GRB2 and GAB1, catalyzes phosphorylation of PIP2 and its conversion to PIP3, which leads to the activation of the AKT signaling.
Literature References
PubMed ID Title Journal Year
15550174 The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway

Schlessinger, J, Lax, I, Lamothe, B, Mattoon, DR

BMC Biol 2004
Participants
Events
Participates
as an event of
Orthologous Events
GAB1 signalosome (Bos taurus)
GAB1 signalosome (Caenorhabditis elegans)
GAB1 signalosome (Canis familiaris)
GAB1 signalosome (Danio rerio)
GAB1 signalosome (Drosophila melanogaster)
GAB1 signalosome (Gallus gallus)
GAB1 signalosome (Mus musculus)
GAB1 signalosome (Rattus norvegicus)
GAB1 signalosome (Sus scrofa)
GAB1 signalosome (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-05-18)
Cite Us!