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CSK [plasma membrane]
Stable Identifier
R-HSA-180499
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Tyrosine-protein kinase CSK
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
Inactivation of Lck by Csk (Homo sapiens)
CSK [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
GAB1 signalosome (Homo sapiens)
Sustained activation of SRC kinase by SHP2 (Homo sapiens)
CSK [plasma membrane] (Homo sapiens)
p-Y-PXN:CSK:MyrG,p-Y530-SRC [plasma membrane] (Homo sapiens)
CSK [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P41240 CSK
Gene Names
CSK
Chain
initiator methionine:, chain:2-450
Reference Genes
BioGPS Gene:1445 CSK
COSMIC (genes):CSK CSK
CTD Gene:1445 CSK
dbSNP Gene:1445 CSK
ENSEMBL:ENSG00000103653 CSK
ENSEMBL_homo_sapiens_GENE:ENSG00000103653.17 CSK
HGNC:2444 CSK
KEGG Gene (Homo sapiens):1445 CSK
Monarch:1445 CSK
NCBI Gene:1445 CSK
OMIM:124095 CSK
UCSC:P41240 CSK
Reference Transcript
RefSeq:NM_004383.2 CSK
RefSeq:XM_017021925.1 CSK
RefSeq:XM_005254165.4 CSK
RefSeq:NM_001127190.1 CSK
Other Identifiers
11724484_a_at
11724485_x_at
11740061_a_at
11751031_a_at
1445
16803059
1768_s_at
202329_PM_at
202329_at
3601851
3601852
3601853
3601854
3601855
3601856
3601859
3601861
3601862
3601865
3601867
3601868
3601870
3601871
3601873
3601875
3601876
3601877
3601878
3601880
3601881
3601883
3601884
3601885
7984871
A_23_P152024
GE59856
GO:0000166
GO:0002250
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0006468
GO:0007155
GO:0008285
GO:0010989
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0019903
GO:0023052
GO:0030154
GO:0031295
GO:0032715
GO:0034236
GO:0034330
GO:0034332
GO:0036211
GO:0042802
GO:0042997
GO:0043226
GO:0045779
GO:0046872
GO:0048709
GO:0048856
GO:0050765
GO:0050852
GO:0060368
GO:0070062
GO:0070064
GO:0070373
GO:0071375
GO:0072659
GO:0140096
GO:1990782
HMNXSV003034834
ILMN_1754121
PH_hs_0004489
TC15000685.hg
X59932_s_at
g4758077_3p_at
Participates
as an output of
Sustained activation of SRC kinase by SHP2 (Homo sapiens)
as a component of
p-Y-PXN:CSK:MyrG,p-Y530-SRC [plasma membrane] (Homo sapiens)
Other forms of this molecule
CSK [cytosol]
Inferred To
CSK [plasma membrane]
(Bos taurus)
CSK [plasma membrane]
(Canis familiaris)
CSK [plasma membrane]
(Danio rerio)
CSK [plasma membrane]
(Drosophila melanogaster)
CSK [plasma membrane]
(Gallus gallus)
CSK [plasma membrane]
(Mus musculus)
CSK [plasma membrane]
(Rattus norvegicus)
CSK [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001120662.1
,
XP_016877414.1
,
NP_004374.1
,
XP_005254222.1
ZINC - World Drugs
CSK_HUMAN
Guide to Pharmacology - Targets
1994
OpenTargets
ENSG00000103653
ZINC - FDA approved
CSK_HUMAN
ZINC - Substances
CSK_HUMAN
ZINC - Biogenic
CSK_HUMAN
ZINC target
P41240
PRO
P41240
PDB
3EAC
,
3D7T
,
3EAZ
,
1BYG
,
1CSK
,
3D7U
ZINC - Investigational
CSK_HUMAN
IntEnz
2.7.10.2
GeneCards
P41240
HPA
ENSG00000103653-CSK
Ensembl
ENST00000220003
,
ENSP00000220003
,
ENST00000439220
,
ENSP00000414764
,
ENST00000567571
,
ENSP00000454906
,
ENSG00000103653
Pharos - Targets
P41240
ZINC - Predictions - Purchasable
CSK_HUMAN
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NWQ8 PAG1
2
PAG1 [plasma membrane]
(R-HSA-180500)
p-Y317-PAG1 [plasma membrane]
(R-HSA-180494)
0.823
6
UniProt:P00523 SRC
9
SRC [cytosol]
(R-GGA-9628701)
phospho-p-Y419-SRC [cytosol]
(R-GGA-8964276)
Src [cytosol]
(R-GGA-3928468)
MyrG-SRC [plasma membrane]
(R-GGA-8876922)
phospho-p-Y419-SRC [cytosol]
(R-GGA-377592)
phospho-MyrG,p-Y530-SRC [plasma membrane]
(R-GGA-377598)
SRC-1 [plasma membrane]
(R-GGA-65043)
phospho-MyrG-p-Y419-SRC [plasma membrane]
(R-GGA-1810408)
SRC-2 [cytosol]
(R-GGA-191648)
0.719
7
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.681
3
UniProt:Q63HR2 TENS2
0.671
4
UniProt:P42685 FRK
4
FRK [specific granule lumen]
(R-HSA-6801037)
FRK [extracellular region]
(R-HSA-6806235)
FRK [azurophil granule lumen]
(R-HSA-6799142)
p-Y387-FRK [cytosol]
(R-HSA-8847965)
0.643
3
UniProt:Q68CZ2 TNS3
1
TNS3 [cytosol]
(R-HSA-8875524)
0.643
4
UniProt:P08575 PTPRC
2
PTPRC [secretory granule membrane]
(R-HSA-6806150)
PTPRC [plasma membrane]
(R-HSA-197931)
0.623
3
UniProt:P49023 PXN
4
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [plasma membrane]
(R-HSA-180493)
PXN [cytosol]
(R-HSA-210014)
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
0.623
4
UniProt:Q7VLE8 Q7VLE8
0.591
4
UniProt:P08069 IGF1R
3
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
0.567
8
UniProt:Q13283 G3BP1
1
G3BP1 [cytosol]
(R-HSA-9729517)
0.556
3
UniProt:Q5T7N3 KANK4
0.556
3
UniProt:Q96D03 DDT4L
0.556
3
UniProt:P42679 MATK
1
MATK [cytosol]
(R-HSA-1433581)
0.527
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:Q9F220 Q9F220
0.524
2
ChEBI:39112 BOSUTINIB
0.499
2
UniProt:Q6UWF3 SCIMP
0.499
3
ChEBI:49375 DASATINIB
0.499
2
UniProt:O15530 PDPK1
3
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.488
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.483
2
UniProt:Q8NHL6 LILRB1
1
LILRB1 [plasma membrane]
(R-HSA-197721)
0.482
2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
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