Reactome | CSK [plasma membrane]

CSK [plasma membrane]

Stable Identifier

R-HSA-180499

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Tyrosine-protein kinase CSK

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Locations in the PathwayBrowser for interactor UniProt:P08575 PTPRC

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External Reference Information

External Reference

UniProt:P41240 CSK

Gene Names

CSK

Chain

initiator methionine:, chain:2-450

Reference Genes

BioGPS Gene:1445 CSK

COSMIC (genes):CSK CSK

CTD Gene:1445 CSK

dbSNP Gene:1445 CSK

ENSEMBL:ENSG00000103653 CSK

HGNC:2444 CSK

KEGG:hsa:1445 CSK

Monarch:1445 CSK

NCBI Gene:1445 CSK

OMIM:124095 CSK

UCSC:P41240 CSK

Reference Transcript

Other Identifiers

11724484_a_at

11724485_x_at

11740061_a_at

11751031_a_at

1445

16803059

1768_s_at

202329_PM_at

202329_at

3601851

3601852

3601853

3601854

3601855

3601856

3601859

3601861

3601862

3601864

3601865

3601866

3601867

3601868

3601869

3601870

3601871

3601872

3601873

3601874

3601875

3601876

3601877

3601878

3601879

3601880

3601881

3601882

3601883

3601884

3601885

7984871

A_23_P152024

GE59856

GO:0002250

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006468

GO:0008285

GO:0010989

GO:0016740

GO:0019903

GO:0030154

GO:0031295

GO:0032715

GO:0034236

GO:0034330

GO:0034332

GO:0042802

GO:0042997

GO:0043226

GO:0045779

GO:0046872

GO:0048709

GO:0050765

GO:0050852

GO:0060368

GO:0070062

GO:0070064

GO:0070373

GO:0071375

GO:0140096

GO:1990782

HMNXSV003034834

ILMN_1754121

PH_hs_0004489

TC15000685.hg

X59932_s_at

g4758077_3p_at

Participates

as an output of

Sustained activation of SRC kinase by SHP2 (Homo sapiens)

as a component of

p-Y-PXN:CSK:MyrG,p-Y530-SRC [plasma membrane] (Homo sapiens)

Other forms of this molecule

CSK [cytosol]

Inferred To

CSK [plasma membrane] (Bos taurus)

CSK [plasma membrane] (Canis familiaris)

CSK [plasma membrane] (Danio rerio)

CSK [plasma membrane] (Drosophila melanogaster)

CSK [plasma membrane] (Gallus gallus)

CSK [plasma membrane] (Mus musculus)

CSK [plasma membrane] (Rattus norvegicus)

CSK [plasma membrane] (Sus scrofa)

Cross References

RefSeq

XP_005254222.1, NP_004374.1, NP_001120662.1, XP_016877414.1

ZINC - World Drugs

CSK_HUMAN

Guide to Pharmacology - Targets

1994

OpenTargets

ENSG00000103653

ENSEMBL

ENST00000439220, ENST00000567571, ENSP00000220003, ENSP00000454906, ENST00000220003, ENSP00000414764

ZINC - FDA approved

CSK_HUMAN

ZINC - Substances

CSK_HUMAN

ZINC - Biogenic

CSK_HUMAN

ZINC target

P41240

PRO

P41240

GlyGen

P41240

PDB

3EAZ, 3EAC, 1BYG, 3D7T, 1CSK, 3D7U

ZINC - Investigational

CSK_HUMAN

IntEnz

2.7.10.2

HPA

ENSG00000103653-CSK

Pharos - Targets

P41240

ZINC - Predictions - Purchasable

CSK_HUMAN

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NWQ8 PAG1	2	PAG1 [plasma membrane] (R-HSA-180500) p-Y317-PAG1 [plasma membrane] (R-HSA-180494)	0.823	6
UniProt:P00523 SRC	9	SRC-2 [cytosol] (R-GGA-191648) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-GGA-1810408) SRC-1 [plasma membrane] (R-GGA-65043) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-GGA-377598) phospho-p-Y419-SRC [cytosol] (R-GGA-377592) MyrG-SRC [plasma membrane] (R-GGA-8876922) Src [cytosol] (R-GGA-3928468) phospho-p-Y419-SRC [cytosol] (R-GGA-8964276) SRC [cytosol] (R-GGA-9628701)	0.719	7
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.681	3
UniProt:Q63HR2 TENS2			0.671	4
UniProt:Q68CZ2 TNS3	1	TNS3 [cytosol] (R-HSA-8875524)	0.643	4
UniProt:P42685 FRK	4	p-Y387-FRK [cytosol] (R-HSA-8847965) FRK [specific granule lumen] (R-HSA-6801037) FRK [extracellular region] (R-HSA-6806235) FRK [azurophil granule lumen] (R-HSA-6799142)	0.643	3
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.623	4
UniProt:P08575 PTPRC	2	PTPRC [plasma membrane] (R-HSA-197931) PTPRC [secretory granule membrane] (R-HSA-6806150)	0.623	3
UniProt:Q7VLE8 Q7VLE8			0.591	4
UniProt:P08069 IGF1R	3	p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180)	0.567	8
UniProt:Q96D03 DDT4L			0.556	3
UniProt:Q5T7N3 KANK4			0.556	3
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.556	3
UniProt:P42679 MATK	1	MATK [cytosol] (R-HSA-1433581)	0.527	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:Q9F220 Q9F220			0.524	2
ChEBI:49375 DASATINIB			0.499	2
UniProt:Q6UWF3 SCIMP			0.499	3
ChEBI:39112 BOSUTINIB			0.499	2
UniProt:O15530 PDPK1	3	p-S241-PDPK1 [cytosol] (R-HSA-9860799) PDPK1 [cytosol] (R-HSA-202210) PDPK1 [plasma membrane] (R-HSA-61459)	0.488	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	2
UniProt:Q8NHL6 LILRB1	1	LILRB1 [plasma membrane] (R-HSA-197721)	0.482	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2

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