Reactome | CSK [plasma membrane]

CSK [plasma membrane]

Stable Identifier

R-HSA-180499

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Tyrosine-protein kinase CSK

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Locations in the PathwayBrowser for interactor UniProt:Q9NWQ8 PAG1

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External Reference Information

External Reference

UniProt:P41240 CSK

Gene Names

CSK

Chain

initiator methionine:, chain:2-450

Reference Genes

BioGPS Gene:1445 CSK

COSMIC (genes):CSK CSK

CTD Gene:1445 CSK

dbSNP Gene:1445 CSK

ENSEMBL:ENSG00000103653 CSK

ENSEMBL_homo_sapiens_GENE:ENSG00000103653.17 CSK

HGNC:2444 CSK

KEGG Gene (Homo sapiens):1445 CSK

Monarch:1445 CSK

NCBI Gene:1445 CSK

OMIM:124095 CSK

UCSC:P41240 CSK

Reference Transcript

Other Identifiers

11724484_a_at

11724485_x_at

11740061_a_at

11751031_a_at

1445

16803059

1768_s_at

202329_PM_at

202329_at

3601851

3601852

3601853

3601854

3601855

3601856

3601859

3601861

3601862

3601865

3601867

3601868

3601870

3601871

3601873

3601875

3601876

3601877

3601878

3601880

3601881

3601883

3601884

3601885

7984871

A_23_P152024

GE59856

GO:0000166

GO:0002250

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006468

GO:0007155

GO:0008285

GO:0010989

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0019903

GO:0023052

GO:0030154

GO:0031295

GO:0032715

GO:0034236

GO:0034330

GO:0034332

GO:0036211

GO:0042802

GO:0042997

GO:0043226

GO:0045779

GO:0046872

GO:0048709

GO:0048856

GO:0050765

GO:0050852

GO:0060368

GO:0070062

GO:0070064

GO:0070373

GO:0071375

GO:0072659

GO:0140096

GO:1990782

HMNXSV003034834

ILMN_1754121

PH_hs_0004489

TC15000685.hg

X59932_s_at

g4758077_3p_at

Participates

as an output of

Sustained activation of SRC kinase by SHP2 (Homo sapiens)

as a component of

p-Y-PXN:CSK:MyrG,p-Y530-SRC [plasma membrane] (Homo sapiens)

Other forms of this molecule

CSK [cytosol]

Inferred To

CSK [plasma membrane] (Bos taurus)

CSK [plasma membrane] (Canis familiaris)

CSK [plasma membrane] (Danio rerio)

CSK [plasma membrane] (Drosophila melanogaster)

CSK [plasma membrane] (Gallus gallus)

CSK [plasma membrane] (Mus musculus)

CSK [plasma membrane] (Rattus norvegicus)

CSK [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001120662.1, XP_016877414.1, NP_004374.1, XP_005254222.1

ZINC - World Drugs

CSK_HUMAN

Guide to Pharmacology - Targets

1994

OpenTargets

ENSG00000103653

ZINC - FDA approved

CSK_HUMAN

ZINC - Substances

CSK_HUMAN

ZINC - Biogenic

CSK_HUMAN

ZINC target

P41240

PRO

P41240

PDB

3EAC, 3D7T, 3EAZ, 1BYG, 1CSK, 3D7U

ZINC - Investigational

CSK_HUMAN

IntEnz

2.7.10.2

GeneCards

P41240

HPA

ENSG00000103653-CSK

Ensembl

ENST00000220003, ENSP00000220003, ENST00000439220, ENSP00000414764, ENST00000567571, ENSP00000454906, ENSG00000103653

Pharos - Targets

P41240

ZINC - Predictions - Purchasable

CSK_HUMAN

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NWQ8 PAG1	2	PAG1 [plasma membrane] (R-HSA-180500) p-Y317-PAG1 [plasma membrane] (R-HSA-180494)	0.823	6
UniProt:P00523 SRC	9	SRC [cytosol] (R-GGA-9628701) phospho-p-Y419-SRC [cytosol] (R-GGA-8964276) Src [cytosol] (R-GGA-3928468) MyrG-SRC [plasma membrane] (R-GGA-8876922) phospho-p-Y419-SRC [cytosol] (R-GGA-377592) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-GGA-377598) SRC-1 [plasma membrane] (R-GGA-65043) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-GGA-1810408) SRC-2 [cytosol] (R-GGA-191648)	0.719	7
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.681	3
UniProt:Q63HR2 TENS2			0.671	4
UniProt:P42685 FRK	4	FRK [specific granule lumen] (R-HSA-6801037) FRK [extracellular region] (R-HSA-6806235) FRK [azurophil granule lumen] (R-HSA-6799142) p-Y387-FRK [cytosol] (R-HSA-8847965)	0.643	3
UniProt:Q68CZ2 TNS3	1	TNS3 [cytosol] (R-HSA-8875524)	0.643	4
UniProt:P08575 PTPRC	2	PTPRC [secretory granule membrane] (R-HSA-6806150) PTPRC [plasma membrane] (R-HSA-197931)	0.623	3
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.623	4
UniProt:Q7VLE8 Q7VLE8			0.591	4
UniProt:P08069 IGF1R	3	IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.567	8
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.556	3
UniProt:Q5T7N3 KANK4			0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:P42679 MATK	1	MATK [cytosol] (R-HSA-1433581)	0.527	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:Q9F220 Q9F220			0.524	2
ChEBI:39112 BOSUTINIB			0.499	2
UniProt:Q6UWF3 SCIMP			0.499	3
ChEBI:49375 DASATINIB			0.499	2
UniProt:O15530 PDPK1	3	p-S241-PDPK1 [cytosol] (R-HSA-9860799) PDPK1 [cytosol] (R-HSA-202210) PDPK1 [plasma membrane] (R-HSA-61459)	0.488	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	2
UniProt:Q8NHL6 LILRB1	1	LILRB1 [plasma membrane] (R-HSA-197721)	0.482	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2

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