Reactome | ELOB [cytosol]

ELOB [cytosol]

Stable Identifier

R-HSA-180551

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TCEB2, Transcription elongation factor B polypeptide 2, RNA polymerase II transcription factor SIII subunit B, SIII p18, Elongin-B, Elongin 18 kDa subunit

Locations in the PathwayBrowser for interactor UniProt:P12504 VIF

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External Reference Information

External Reference

UniProt:Q15370 ELOB

Gene Names

ELOB, TCEB2

Chain

chain:1-118

Reference Genes

COSMIC (genes):ELOB ELOB

dbSNP Gene:6923 ELOB

ENSEMBL:ENSG00000103363 ELOB

Participates

as a component of

as an output of

SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Homo sapiens)

as an input of

SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 (Homo sapiens)

Other forms of this molecule

TCEB2 [nucleoplasm]

Inferred To

TCEB2 [cytosol] (Bos taurus)

ELOB [cytosol] (Canis familiaris)

ELOB [cytosol] (Sus scrofa)

EloB [cytosol] (Drosophila melanogaster)

elob [cytosol] (Xenopus tropicalis)

Ghost homologue of ELOB [cytosol] (Danio rerio)

Ghost homologue of ELOB [cytosol] (Dictyostelium discoideum)

Ghost homologue of ELOB [cytosol] (Gallus gallus)

Ghost homologue of ELOB [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of ELOB [cytosol] (Schizosaccharomyces pombe)

Elob [cytosol] (Mus musculus)

Elob [cytosol] (Rattus norvegicus)

elb-1 [cytosol] (Caenorhabditis elegans)

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15369 ELOC	2	TCEB1 [nucleoplasm] (R-HSA-112422) ELOC [cytosol] (R-HSA-180535)	0.952	20
UniProt:P40337 VHL	3	monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697) VHL [nucleoplasm] (R-HSA-1234127) VHL [cytosol] (R-HSA-391423)	0.944	14
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) 2xHP-HIF1A [cytosol] (R-HSA-1234131) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110)	0.789	8
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.725	18
UniProt:Q9UHY1 NRBP1	1	NRBP1 [nucleoplasm] (R-HSA-376332)	0.725	5
UniProt:P78395 PRAME			0.676	7
UniProt:Q13617 CUL2	3	CUL2 [cytosol] (R-HSA-416982) CUL2 [nucleoplasm] (R-HSA-1234126) G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511)	0.643	8
UniProt:A0A663DJA2 ORF10			0.643	3
UniProt:Q96DX5 ASB9	1	ASB9 [cytosol] (R-HSA-975424)	0.643	4
UniProt:Q96S21 RAB40C	2	GGC-RAB40C [cytosol] (R-HSA-8874025) RAB40C [cytosol] (R-HSA-8873693)	0.642	4
UniProt:P12504 VIF			0.558	5
UniProt:Q96EL3 MRPL53	1	MRPL53 [mitochondrial inner membrane] (R-HSA-5368226)	0.556	5
UniProt:Q96G25 MED8	1	MED8 [nucleoplasm] (R-HSA-556784)	0.548	5
UniProt:P40337-3 VHL			0.547	2
UniProt:Q9NWX5 ASB6	1	ASB6 [cytosol] (R-HSA-975412)	0.527	3
UniProt:Q9Y2U9 KLDC2			0.527	2
UniProt:Q6PD62 CTR9	1	CTR9 [nucleoplasm] (R-HSA-8866694)	0.527	2
UniProt:Q96A44 SPSB4	1	SPSB4 [cytosol] (R-HSA-976023)	0.527	2
UniProt:Q99619 SPSB2	1	SPSB2 [cytosol] (R-HSA-976048)	0.527	3
UniProt:O14543 SOCS3	1	SOCS3 [cytosol] (R-HSA-873794)	0.527	3

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