Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex

Stable Identifier
R-HSA-180597
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex
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CD4 is ubiquitinated in the CD4:Vpu–h-ßTrCP:Skp1 complex.

Literature References
PubMed ID Title Journal Year
9660940 A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

Margottin, F, Richard, V, Benarous, R, Durand, H, Selig, L, Strebel, K, Bour, SP, Thomas, D, Benichou, S

Mol Cell 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin-protein transferase activity of CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane]

Physical Entity
CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Matthews, L  (2006-05-15)
Reviewed
Benarous, R  (2006-09-21)
Created
Matthews, L  (2006-05-23)
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