Proteosome-mediated degradation of APOBEC3G

Stable Identifier
R-HSA-180603
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Following multi-ubiquitination by the Vif-Cul5-SCF complex, APOBEC3G is degraded by the 26S proteasome.
Literature References
PubMed ID Title Journal Year
15781449 Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif function

Uchiyama, T, Takaori-Kondo, A, Miyauchi, Y, Iwai, K, Kobayashi, M

J Biol Chem 2005
14564014 Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex

Yu, XF, Luo, K, Kong, W, Mao, P, Liu, B, Yu, X, Yu, Y

Science 2003
14528300 The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif

Gaddis, NC, Sheehy, AM, Malim, MH

Nat Med 2003
Participants
Participates
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Reviewed
Created
Cite Us!